公开(公告)号：EP3331863B1

公开(公告)日：2020-03-11

申请号：EP16756806.2

申请日：2016-08-02

申请人： Glenmark Pharmaceuticals S.A.

发明人： DAS, Sanjib ,  GHARAT, Laxmikant Atmaram ,  HARDE, Rajendra Laxman ,  SHELKE, Sandeep Yadunath ,  PARDESHI, Shailesh Ramesh ,  THOMAS, Abraham ,  KHAIRATKAR-JOSHI, Neelima ,  SHAH, Daisy Manish ,  BAJPAI, Malini

IPC分类号： C07D231/12 ,  C07D401/04 ,  C07D403/04 ,  C07D239/26 ,  C07D239/36 ,  C07D239/42 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12 ,  C07D213/40 ,  A61K31/506 ,  A61P37/00

公开(公告)号：EP3331863A1

公开(公告)日：2018-06-13

申请号：EP16756806.2

申请日：2016-08-02

申请人： Glenmark Pharmaceuticals S.A.

发明人： DAS, Sanjib ,  GHARAT, Laxmikant Atmaram ,  HARDE, Rajendra Laxman ,  SHELKE, Sandeep Yadunath ,  PARDESHI, Shailesh Ramesh ,  THOMAS, Abraham ,  KHAIRATKAR-JOSHI, Neelima ,  SHAH, Daisy Manish ,  BAJPAI, Malini

IPC分类号： C07D231/12 ,  C07D401/04 ,  C07D403/04 ,  C07D239/26 ,  C07D239/36 ,  C07D239/42 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12 ,  C07D213/40 ,  A61K31/506 ,  A61P37/00

摘要： The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, ring B, L, R1, R2, R3, R4, R5, Ra, Rb, n, m, p and q are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.

公开(公告)号：EP3686187A1

公开(公告)日：2020-07-29

申请号：EP20160567.2

申请日：2016-08-02

申请人： Glenmark Pharmaceuticals S.A.

发明人： DAS, Sanjib ,  GHARAT, Laxmikant, Atmaram ,  HARDE, Rajendra, Laxman ,  SHELKE, Sandeep, Yadunath ,  PARDESHI, Shailesh, Ramesh ,  THOMAS, Abraham ,  KHAIRATKAR-JOSHI, Neelima ,  SHAH, Daisy, Manish ,  BAJPAI, Malini

IPC分类号： C07D231/12 ,  C07D401/04 ,  C07D403/04 ,  C07D239/26 ,  C07D239/36 ,  C07D239/42 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12 ,  C07D213/40 ,  A61K31/506 ,  A61P37/00

摘要： The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, ring B, L, R 1 , R 2 , R 3 , R 4 , R 5 , R a , R b , n, m, p and q are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.

公开(公告)号：EP3341357A1

公开(公告)日：2018-07-04

申请号：EP16840923.3

申请日：2016-08-26

申请人： Glenmark Pharmaceuticals S.A.

发明人： DAS, Sanjib ,  GHARAT, Laxmikant Atmaram ,  HARDE, Rajendra Laxman ,  SHELKE, Dnyaneshwar Eknath ,  PARDESHI, Shailesh Ramesh ,  THOMAS, Abraham ,  KHAIRATKAR-JOSHI, Neelima ,  SHAH, Daisy Manish ,  BAJPAI, Malini

IPC分类号： C07C311/16 ,  A61K31/167 ,  A61P35/00

CPC分类号： C07C237/42 ,  A61P11/06 ,  A61P11/08 ,  A61P11/14 ,  A61P17/06 ,  C07B2200/07 ,  C07C2601/02 ,  C07C2601/16

摘要： The present disclosure is directed to novel carbocyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, Ra, Rb, n, m and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.

公开(公告)号：EP3080090B1

公开(公告)日：2018-01-31

申请号：EP14827867.4

申请日：2014-12-09

申请人： Glenmark Pharmaceuticals S.A.

发明人： DAS, Sanjib ,  CHAUDHARI, Sachin Sundarlal ,  THOMAS, Abraham ,  PARDESHI, Shailesh Ramesh ,  DESHMUKH, Vishal Govindrao ,  WADEKAR, Prashant Dilip ,  KHAIRATKAR-JOSHI, Neelima ,  SHAH, Daisy Manish ,  BAJPAI, Malini

IPC分类号： C07D471/04 ,  C07D231/56 ,  C07D401/04 ,  C07D209/12 ,  A61K31/404 ,  A61K31/416 ,  A61K31/4162 ,  A61P37/00

CPC分类号： C07D471/04 ,  C07D209/12 ,  C07D231/56 ,  C07D401/04

摘要： The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein X, X1, M, R2, R3, R4, R5, m, n, and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, neurodegenerative diseases and cancer.

公开(公告)号：EP3131880A1

公开(公告)日：2017-02-22

申请号：EP15723759.5

申请日：2015-04-15

申请人： Glenmark Pharmaceuticals S.A.

发明人： CHAUDHARI, Sachin Sundarlal ,  THOMAS, Abraham ,  KADAM, Ashok Bhausaheb ,  DHONE, Sachin Vasantrao ,  ADIK, Bharat Gangadhar ,  KHAIRATKAR-JOSHI, Neelima ,  SHAH, Daisy Manish ,  BAJPAI, Malini

IPC分类号： C07D213/75 ,  C07D309/12 ,  C07D235/12 ,  C07D401/12 ,  C07D405/12 ,  C07D471/04 ,  C07D271/06 ,  C07D209/12 ,  C07D211/44 ,  C07D211/46 ,  C07D213/61 ,  C07D305/08 ,  A61K31/4184

CPC分类号： C07D213/61 ,  C07C317/44 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07D209/12 ,  C07D211/44 ,  C07D211/46 ,  C07D213/75 ,  C07D235/12 ,  C07D271/06 ,  C07D305/08 ,  C07D309/12 ,  C07D401/12 ,  C07D405/12 ,  C07D471/04

摘要： The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein Ring A, Ring B, R, R
2 , R
3 , n, and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.

摘要翻译： 本公开涉及式（I）化合物及其药学上可接受的盐，其中环A，环B，R，R 2，R 3，n和p如本文所定义，其作为类视黄醇 - 相关的孤儿受体gamma t（RORγt）。 这些化合物预防，抑制或抑制RORγt的作用，因此可用于治疗RORγt介导的疾病，病症，综合征或病症，例如疼痛，炎症，COPD，哮喘，类风湿性关节炎，结肠炎，多发性硬化症， 牛皮癣，神经退行性疾病和癌症。

公开(公告)号：EP3080090A1

公开(公告)日：2016-10-19

申请号：EP14827867.4

申请日：2014-12-09

申请人： Glenmark Pharmaceuticals S.A.

发明人： DAS, Sanjib ,  CHAUDHARI, Sachin Sundarlal ,  THOMAS, Abraham ,  PARDESHI, Shailesh Ramesh ,  DESHMUKH, Vishal Govindrao ,  WADEKAR, Prashant Dilip ,  KHAIRATKAR-JOSHI, Neelima ,  SHAH, Daisy Manish ,  BAJPAI, Malini

IPC分类号： C07D231/56 ,  C07D401/04 ,  C07D209/12 ,  A61K31/404 ,  A61K31/416 ,  A61K31/4162 ,  A61P37/00

CPC分类号： C07D471/04 ,  C07D209/12 ,  C07D231/56 ,  C07D401/04

摘要： The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein X, X1, M, R2, R3, R4, R5, m, n, and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, neurodegenerative diseases and cancer.

摘要翻译： 本公开涉及式（I）的化合物及其药学上可接受的盐，其中X，X1，M，R2，R3，R4，R5，m，n和p如本文所定义，其作为调节剂 类视黄醇相关孤儿受体γt（RORγt）。 这些化合物预防，抑制或抑制RORγt的作用，因此可用于治疗RORγt介导的疾病，病症，综合征或病症，例如疼痛，炎症，COPD，哮喘，类风湿性关节炎，结肠炎，多发性硬化症， 神经退行性疾病和癌症。