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1.发明公开SALZE SUBSTITUIERTER 1,2,3,4-TETRAHYDROCHINOLIN-2-CARBONSAUREDERIVATE ALS NMDA-ANTAGONISTEN 审中-公开取代的1,2,3,4-四氢喹啉-2-二氧化碳衍生物作为NMDA拮抗剂的盐
公开(公告)号：EP1411947A2
公开(公告)日：2004-04-28
申请号：EP02772122.4
申请日：2002-08-05
申请人： Grünenthal GmbH
IPC分类号： A61K31/47 , A61K31/4738 , C07D221/16 , C07D491/04 , C07D221/18 , A61P25/04 , C07D215/48
CPC分类号： C07D491/04 , C07D215/48 , C07D221/16 , C07D221/18
摘要： The invention relates to salts of substituted 1, 2, 3, 4-tetrahydroquinoline-2-carboxylic acid derivatives of formula (I), in addition to methods for the production thereof, the use thereof in he production of medicaments and medicaments containing said compounds.
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2.发明授权SUBSTITUIERTE 5,6,6A,11B-TETRAHYDRO-7-OXA-5-AZA-BENZO[C]FLUOREN-6-CARBONSÄUREDERIVATE ALS NMDA-ANTAGONISTEN 有权取代的5,6,6a，11B四氢-7-氧杂-5-氮杂 - 苯并[c]芴-6-羧酸衍生物作为NMDA拮抗剂
公开(公告)号：EP1412361B1
公开(公告)日：2008-07-23
申请号：EP02764838.5
申请日：2002-08-05
申请人： Grünenthal GmbH
发明人： GERLACH, Matthias , PRZEWOSNY, Michael , ENGLBERGER, Werner, Günter , REISSMÜLLER, Elke , BLOMS-FUNKE, Petra , MAUL, Corinna , JAGUSCH, Utz-Peter
IPC分类号： C07D491/04 , A61K31/445 , A61K31/34 , A61P25/04 , A61P25/06 , A61P25/00
CPC分类号： C07D491/04
摘要： The invention relates to substituted 5,6,6a,11b-tetrahydro-7-oxa-5-aza-benzo[c]fluorene-6-carboxylic acid derivatives, to methods for the production thereof, medicaments containing these compounds, and to their use for producing medicaments for certain indications, particularly for treating pain.
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3.发明公开SUBSTITUIERTE 5,6,6A,11B-TETRAHYDRO-7-OXA-5-AZA-BENZO[C]FLUOREN-6-CARBONSÄUREDERIVATE ALS NMDA-ANTAGONISTEN 有权取代的5,6,6a，11B四氢-7-氧杂-5-氮杂 - 苯并[c]芴-6-羧酸衍生物作为NMDA拮抗剂
公开(公告)号：EP1412361A1
公开(公告)日：2004-04-28
申请号：EP02764838.5
申请日：2002-08-05
申请人： Grünenthal GmbH
发明人： GERLACH, Matthias , PRZEWOSNY, Michael , ENGLBERGER, Werner, Günter , REISSMÜLLER, Elke , BLOMS-FUNKE, Petra , MAUL, Corinna , JAGUSCH, Utz-Peter
IPC分类号： C07D491/04 , A61K31/445 , A61K31/34 , A61P25/04 , A61P25/06 , A61P25/00
CPC分类号： C07D491/04
摘要： The invention relates to substituted 5,6,6a,11b-tetrahydro-7-oxa-5-aza-benzo[c]fluorene-6-carboxylic acid derivatives, to methods for the production thereof, medicaments containing these compounds, and to their use for producing medicaments for certain indications, particularly for treating pain.
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4.发明公开SUBSTITUIERTE 1-OXA-2,8-DIAZA-SPIRO[4,5]DEC-2-EN-DERIVATE ALS ARZNEIMITTEL GEGEN SCHMERZ 有权取代的1-氧杂-2,8-二氮杂螺[4,5]癸-2-烯衍生物作为药物抗PAIN
公开(公告)号：EP1401841A1
公开(公告)日：2004-03-31
申请号：EP02735422.4
申请日：2002-06-21
申请人： Grünenthal GmbH
发明人： BUSCHMANN, Helmut, Heinrich , ENGLBERGER, Werner, Günter , GERMANN, Tieno , HENNIES, Hagen-Heinrich , MAUL, Corinna , SUNDERMANN, Bernd , HOLENZ, Jörg , HAURAND, Michael
IPC分类号： C07D498/10 , A61K31/438 , A61P29/02
CPC分类号： C07D498/10 , Y02P20/55
摘要： The invention relates to substituted 1-oxa-2,8-diaza-spiro[4,5]dec-2-ene derivatives of general formula (I), method for production thereof, use thereof for production of medicaments and medicaments comprising said compounds.
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5.发明授权SUBSTITUIERTE 1-OXA-2,8-DIAZA-SPIRO[4,5]DEC-2-EN-DERIVATE ALS ARZNEIMITTEL GEGEN SCHMERZ 有权取代的1-氧杂-2,8-二氮杂螺[4,5]癸-2-烯衍生物作为药物抗PAIN
公开(公告)号：EP1401841B1
公开(公告)日：2005-08-24
申请号：EP02735422.4
申请日：2002-06-21
申请人： Grünenthal GmbH
发明人： BUSCHMANN, Helmut, Heinrich , ENGLBERGER, Werner, Günter , GERMANN, Tieno , HENNIES, Hagen-Heinrich , MAUL, Corinna , SUNDERMANN, Bernd , HOLENZ, Jörg , HAURAND, Michael
IPC分类号： C07D498/10 , A61K31/438 , A61P29/02
CPC分类号： C07D498/10 , Y02P20/55
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公开(公告)号：EP1085866A1
公开(公告)日：2001-03-28
申请号：EP99931054.3
申请日：1999-06-11
申请人： Grünenthal GmbH
IPC分类号： A61K31/435
CPC分类号： A61K31/435
摘要： The present invention relates to the use of benzomorphan derivatives of the general formula (I) as analgesic agents, wherein X is oxygen or sulphur; R1 is C1-C8 alkyl, C3-C6 alkenyl, C3-C6 alkinyl or aryl; R2 is hydrogen, C¿1?-C8 alkyl, C3-C6 alkenyl or C3-C6 alkinyl; R?3¿ is hydrogen or C¿1?-C6 alkyl; R?4 is C¿1-C8 alkyl; R5 is C1-C8 alkyl; R6 is C1-C8 alkyl; and R?7 and R8¿ represent independently hydrogen, C¿1?-C8 alkyl, halogen, OH, C1-C8 alkoxy, -O-acyl, -CN, -NO2, -NH2, -NH(C1-C8 alkyl) or -N(C1-C8 alkyl)2. The alkyl radicals may be the same and represent -NH-acyl or N-acyl-(C1-C8 alkyl) in their diastereomeric, enantiomeric, basic or physiologically-acceptable acid-salt forms.
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