公开(公告)号：EP4168592A1

公开(公告)日：2023-04-26

申请号：EP21740365.8

申请日：2021-06-17

申请人： Grail, LLC

发明人： CALEF, Robert Abe Paine ,  MAHER, M. Cyrus ,  BEAUSANG, John F. ,  BREDNO, Joerg ,  VENN, Oliver Claude ,  FIELDS, Alexander P. ,  JAMSHIDI, Arash

IPC分类号： C12Q1/6886 ,  C12Q1/70

公开(公告)号：EP4353834A3

公开(公告)日：2024-05-01

申请号：EP23217634.7

申请日：2020-01-24

申请人： Grail, LLC

发明人： VENN, Oliver Claude ,  FIELDS, Alexander P. ,  GROSS, Samuel S. ,  LIU, Qinwen ,  SCHELLENBERGER, Jan ,  BREDNO, Joerg ,  BEAUSANG, John F. ,  SHOJAEE, Seyedmehdi ,  SAKARYA, Onur ,  MAHER, M. Cyrus ,  JAMSHIDI, Arash

IPC分类号： C12Q1/6886 ,  C12Q1/6832

CPC分类号： C12Q1/6886 ,  C12Q2600/15420130101 ,  C12Q1/6832

摘要： The present invention provides a method of assaying a sample for presence of nucleic acids from cells of a cancer type in a subject, the method comprising capturing converted cell-free DNA (cfDNA) fragments from the sample or amplification products thereof with a composition comprising a plurality of different bait oligonucleotides.

公开(公告)号：EP4353834A2

公开(公告)日：2024-04-17

申请号：EP23217634.7

申请日：2020-01-24

申请人： Grail, LLC

发明人： VENN, Oliver Claude ,  FIELDS, Alexander P. ,  GROSS, Samuel S. ,  LIU, Qinwen ,  SCHELLENBERGER, Jan ,  BREDNO, Joerg ,  BEAUSANG, John F. ,  SHOJAEE, Seyedmehdi ,  SAKARYA, Onur ,  MAHER, M. Cyrus ,  JAMSHIDI, Arash

IPC分类号： C12Q1/6832

CPC分类号： C12Q1/6886 ,  C12Q2600/15420130101 ,  C12Q1/6832

摘要： The present invention provides a method of assaying a sample for presence of nucleic acids from cells of a cancer type in a subject, the method comprising capturing converted cell-free DNA (cfDNA) fragments from the sample or amplification products thereof with a composition comprising a plurality of different bait oligonucleotides.