公开(公告)号：EP4257701A2

公开(公告)日：2023-10-11

申请号：EP23189098.9

申请日：2017-06-29

申请人： Grail, LLC

发明人： LARSON, Matthew ,  KIM, H. John ,  EATTOCK, Nicholas ,  JAMSHIDI, Arash

IPC分类号： C12Q1/6806

摘要： In various aspects, the present disclosure provides methods, compositions, reactions mixtures, kits, and systems for sequencing both RNA and DNA from a single source sample. In some embodiments, RNA is treated so as to differentiate RNA sequences from DNA sequences derived from the same sample. In some embodiments, the RNA and DNA are cell-free polynucleotides.

公开(公告)号：EP4257701A3

公开(公告)日：2023-12-20

申请号：EP23189098.9

申请日：2017-06-29

申请人： Grail, LLC

发明人： LARSON, Matthew ,  KIM, H. John ,  EATTOCK, Nicholas ,  JAMSHIDI, Arash

IPC分类号： C12Q1/6806 ,  C12Q1/6869

摘要： In various aspects, the present disclosure provides methods, compositions, reactions mixtures, kits, and systems for sequencing both RNA and DNA from a single source sample. In some embodiments, RNA is treated so as to differentiate RNA sequences from DNA sequences derived from the same sample. In some embodiments, the RNA and DNA are cell-free polynucleotides.

公开(公告)号：EP4168592A1

公开(公告)日：2023-04-26

申请号：EP21740365.8

申请日：2021-06-17

申请人： Grail, LLC

发明人： CALEF, Robert Abe Paine ,  MAHER, M. Cyrus ,  BEAUSANG, John F. ,  BREDNO, Joerg ,  VENN, Oliver Claude ,  FIELDS, Alexander P. ,  JAMSHIDI, Arash

IPC分类号： C12Q1/6886 ,  C12Q1/70

公开(公告)号：EP4302299A1

公开(公告)日：2024-01-10

申请号：EP22723509.0

申请日：2022-04-05

申请人： Grail, LLC

发明人： VENN, Oliver, Claude ,  FREESE, Peter, D. ,  GROSS, Samuel, S. ,  CALEF, Robert, Abe Paine ,  JAMSHIDI, Arash

IPC分类号： G16B5/20 ,  C12Q1/6886 ,  C12Q1/6869

公开(公告)号：EP4353834A2

公开(公告)日：2024-04-17

申请号：EP23217634.7

申请日：2020-01-24

申请人： Grail, LLC

发明人： VENN, Oliver Claude ,  FIELDS, Alexander P. ,  GROSS, Samuel S. ,  LIU, Qinwen ,  SCHELLENBERGER, Jan ,  BREDNO, Joerg ,  BEAUSANG, John F. ,  SHOJAEE, Seyedmehdi ,  SAKARYA, Onur ,  MAHER, M. Cyrus ,  JAMSHIDI, Arash

IPC分类号： C12Q1/6832

CPC分类号： C12Q1/6886 ,  C12Q2600/15420130101 ,  C12Q1/6832

摘要： The present invention provides a method of assaying a sample for presence of nucleic acids from cells of a cancer type in a subject, the method comprising capturing converted cell-free DNA (cfDNA) fragments from the sample or amplification products thereof with a composition comprising a plurality of different bait oligonucleotides.

公开(公告)号：EP4353834A3

公开(公告)日：2024-05-01

申请号：EP23217634.7

申请日：2020-01-24

申请人： Grail, LLC

发明人： VENN, Oliver Claude ,  FIELDS, Alexander P. ,  GROSS, Samuel S. ,  LIU, Qinwen ,  SCHELLENBERGER, Jan ,  BREDNO, Joerg ,  BEAUSANG, John F. ,  SHOJAEE, Seyedmehdi ,  SAKARYA, Onur ,  MAHER, M. Cyrus ,  JAMSHIDI, Arash

IPC分类号： C12Q1/6886 ,  C12Q1/6832

CPC分类号： C12Q1/6886 ,  C12Q2600/15420130101 ,  C12Q1/6832

摘要： The present invention provides a method of assaying a sample for presence of nucleic acids from cells of a cancer type in a subject, the method comprising capturing converted cell-free DNA (cfDNA) fragments from the sample or amplification products thereof with a composition comprising a plurality of different bait oligonucleotides.

公开(公告)号：EP4165206A2

公开(公告)日：2023-04-19

申请号：EP21826943.9

申请日：2021-06-16

申请人： Grail, LLC

发明人： MAUNTZ, Ruth, E. ,  LARSON, Matthew ,  SHENOY, Archana ,  JAMSHIDI, Arash ,  BURKHARDT, David

IPC分类号： C12Q1/6809 ,  C12Q1/6886