公开(公告)号：EP4257701A3

公开(公告)日：2023-12-20

申请号：EP23189098.9

申请日：2017-06-29

申请人： Grail, LLC

发明人： LARSON, Matthew ,  KIM, H. John ,  EATTOCK, Nicholas ,  JAMSHIDI, Arash

IPC分类号： C12Q1/6806 ,  C12Q1/6869

摘要： In various aspects, the present disclosure provides methods, compositions, reactions mixtures, kits, and systems for sequencing both RNA and DNA from a single source sample. In some embodiments, RNA is treated so as to differentiate RNA sequences from DNA sequences derived from the same sample. In some embodiments, the RNA and DNA are cell-free polynucleotides.

公开(公告)号：EP4257701A2

公开(公告)日：2023-10-11

申请号：EP23189098.9

申请日：2017-06-29

申请人： Grail, LLC

发明人： LARSON, Matthew ,  KIM, H. John ,  EATTOCK, Nicholas ,  JAMSHIDI, Arash

IPC分类号： C12Q1/6806

摘要： In various aspects, the present disclosure provides methods, compositions, reactions mixtures, kits, and systems for sequencing both RNA and DNA from a single source sample. In some embodiments, RNA is treated so as to differentiate RNA sequences from DNA sequences derived from the same sample. In some embodiments, the RNA and DNA are cell-free polynucleotides.