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1.发明授权
公开(公告)号：EP3121268B1
公开(公告)日：2018-12-26
申请号：EP16179299.9
申请日：2016-07-13
申请人： Grifols, S.A.
发明人： BUNO, Brett , JOURNIGAN, Terri , HOTTA, Joann , BURDICK, Michael
IPC分类号： C12N7/00 , G01N33/576 , C12Q1/70
CPC分类号： C12N7/00 , C12N2770/28151 , C12Q1/706 , C12Q1/707 , G01N33/576 , G01N33/5768
摘要： Provided herein is a method of purification of non-enveloped or pseudo-enveloped virus produced in vitro using a composition with at least one detergent. Also provided are a method of purification can use multiple detergents, and a method of determining the presence and/or level of a non-enveloped or pseudo-enveloped virus in a sample.
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2.发明公开METHOD FOR GENERATING HIGH-TITER HEPATITIS E VIRUS STOCKS AND TITRATION ASSAY FOR HEPATITIS E VIRUS 有权VERFAHREN ZUR ERZEUGUNG VON HOCHTITRIGEN HEPATITIS-E-VIRUSSTÄEMENUND TITRATIONSASSAYFÜRDAS HEPATITIS-E-VIRUS
公开(公告)号：EP3121267A1
公开(公告)日：2017-01-25
申请号：EP16178844.3
申请日：2016-07-11
申请人： Grifols, S.A.
发明人： BUNO, Brett , JOURNIGAN, Terri , HOTTA, Joann , BURDICK, Michael
IPC分类号： C12N7/00 , C12N5/071 , G01N33/576 , C12Q1/70
CPC分类号： C12N7/00 , C12N5/0018 , C12N2501/05 , C12N2770/28151 , C12Q1/706 , C12Q1/707 , G01N33/576
摘要： Provided herein are the use of polybrene as an additive in cell culture medium used in methods for the generation of high-titer hepatitis E virus stocks and assays for titration of hepatitis E virus. Also provided are a cell culture medium containing polybrene for high-titer HEV generation, a method for determining the presence and/or the level of HEV in a sample, and an HEV titration assay using polybrene.
摘要翻译： 本文提供了使用聚凝胺作为用于产生高滴度戊型肝炎病毒原种的方法和用于滴定戊型肝炎病毒的测定法的细胞培养基中的添加剂。 还提供了含有用于高滴度HEV产生的聚凝胺的细胞培养基，用于测定样品中HEV的存在和/或水平的方法和使用聚凝胺的HEV滴定测定法。
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3.发明授权METHOD FOR GENERATING HIGH-TITER HEPATITIS E VIRUS STOCKS AND TITRATION ASSAY FOR HEPATITIS E VIRUS 有权产生高滴度乙型肝炎病毒储存的方法和用于乙型肝炎病毒的滴定测定
公开(公告)号：EP3121267B1
公开(公告)日：2018-03-28
申请号：EP16178844.3
申请日：2016-07-11
申请人： Grifols, S.A.
发明人： BUNO, Brett , JOURNIGAN, Terri , HOTTA, Joann , BURDICK, Michael
IPC分类号： C12N7/00 , C12N5/071 , G01N33/576 , C12Q1/70
CPC分类号： C12N7/00 , C12N5/0018 , C12N2501/05 , C12N2770/28151 , C12Q1/706 , C12Q1/707 , G01N33/576
摘要： Provided herein are the use of polybrene as an additive in cell culture medium used in methods for the generation of high-titer hepatitis E virus stocks and assays for titration of hepatitis E virus. Also provided are a cell culture medium containing polybrene for high-titer HEV generation, a method for determining the presence and/or the level of HEV in a sample, and an HEV titration assay using polybrene.
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4.发明公开METHODS FOR PURIFICATION OF A VIRUS PRODUCED IN VITRO AND CLEARANCE ASSAY FOR THE VIRUS 审中-公开VERFAHREN ZUR REINIGUNG EINES IN-VITRO-HERGESTELLIVE VIRUS UND CLEARANCE-ASSAYFÜRDAS VIRUS
公开(公告)号：EP3121268A1
公开(公告)日：2017-01-25
申请号：EP16179299.9
申请日：2016-07-13
申请人： Grifols, S.A.
发明人： BUNO, Brett , JOURNIGAN, Terri , HOTTA, Joann , BURDICK, Michael
IPC分类号： C12N7/00 , G01N33/576 , C12Q1/70
CPC分类号： C12N7/00 , C12N2770/28151 , C12Q1/706 , C12Q1/707 , G01N33/576 , G01N33/5768
摘要： Provided herein is a method of purification of non-enveloped or pseudo-enveloped virus produced in vitro using a composition with at least one detergent. Also provided are a method of purification can use multiple detergents, and a method of determining the presence and/or level of a non-enveloped or pseudo-enveloped virus in a sample.
摘要翻译： 本文提供了使用具有至少一种洗涤剂的组合物在体外产生的无包膜或假包膜病毒的纯化方法。 还提供了可以使用多种洗涤剂的纯化方法，以及确定样品中未包封或伪包膜病毒的存在和/或水平的方法。
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