公开(公告)号：EP2834620A1

公开(公告)日：2015-02-11

申请号：EP13719647.3

申请日：2013-04-04

Applicant: Grove Instruments Inc.

Inventor： HARJUNMAA, Hannu ,  KUN, Stevan

IPC: G01N21/31 ,  G01N21/35 ,  G01N21/49 ,  G01N21/17 ,  A61B5/00 ,  A61B5/026 ,  A61B5/145 ,  G01N33/49 ,  A61B5/1455

CPC classification number: A61B5/14532 ,  A61B5/0051 ,  A61B5/1455 ,  A61B5/6816 ,  A61B5/6826 ,  A61B2560/0431 ,  A61B2562/0233 ,  A61B2562/146 ,  F04C2270/041 ,  G01N21/1717 ,  G01N21/314 ,  G01N21/359 ,  G01N21/474 ,  G01N21/49 ,  G01N33/49 ,  G01N2021/3148 ,  G01N2021/4709 ,  G01N2021/475 ,  G01N2201/0221 ,  G01N2201/0631 ,  G01N2201/0636

Abstract: A method and apparatus for noninvasively measuring the concentration of a target analyte in a sample matrix (22), using a fiberless transflectance probe (20). It includes directing a beam of electromagnetic radiation, consisting of at least two components of different wavelengths, to the sample matrix (22) and conducting the backscattered radiation to a detector (18) which outputs a signal indicative of the differential absorption of the two wavelengths in the sample matrix (22). The transflectance probe (20) comprises a tapered tubular housing (50) having an inner reflective surface (52), an optical rod (40) having an outer reflective surface (45), and a detection window (46) which serves as an interface between the probe and the surface of the sample matrix (22). The method and apparatus described are particularly useful in measuring the concentration of glucose in tissue (22) containing blood.

公开(公告)号：EP2073697A2

公开(公告)日：2009-07-01

申请号：EP07811716.5

申请日：2007-09-10

Applicant: Grove Instruments, Inc.

Inventor： HARJUNMAA, Hannu ,  KUN, Stevan ,  BURRELL, Rebecca ,  LUENBERGER, Georg

IPC: A61B5/00 ,  G01N21/31

CPC classification number: G01N21/3151 ,  A61B5/14532 ,  A61B5/1455 ,  G01N21/35 ,  G01N21/49

Abstract: An improved method for non-invasively measuring a concentration of a target analyte dissolved in a fluid flowing through a sample is presented. It includes directing a probe beam of electromagnetic radiation, consisting of time multiplexed components of different wavelengths, where at least one of the time-multiplexed components consists of two different simultaneous wavelengths, whose intensity relation defines the effective wavelength of their combination, through the sample and measuring the difference of the absorption of the radiation of the time- multiplexed components at different sample states. During sample state changes, the amount of fluid containing the target analyte within the sample is changing, which varies the total amount of target analyte in the sample, as well as the absorption properties of the sample. The sample states are produced, for instance, by compressing and uncompressing the tissue sample. The accuracy of the presented method is enhanced. by including continuous estimation of the amount of the fluid containing the target analyte within the sample, and measurement of the variations of the absorption at a wavelength at which the target analyte absorbs significantly. The method is particularly useful in measuring the concentration of a target analyte, such as glucose, in tissue containing blood. An apparatus for performing this method also is disclosed.