公开(公告)号：EP2591785B1

公开(公告)日：2017-01-04

申请号：EP11803155.8

申请日：2011-07-08

申请人： Guangzhou Cellprotek Pharmaceutical Co., Ltd.

发明人： YAN, Guangmei ,  HU, Haiyan ,  LENG, Tiandong ,  SANG, Hanfei ,  ZHANG, Jingxia ,  QIU, Pengxin ,  ZHOU, Shujia ,  CHEN, Jiesi ,  YOU, Xiuhua

IPC分类号： A61K31/568 ,  A61P25/00 ,  A61P9/10

CPC分类号： A61K31/568 ,  C07J1/0007

公开(公告)号：EP2620153B1

公开(公告)日：2018-04-18

申请号：EP11826361.5

申请日：2011-07-08

申请人： Guangzhou Cellprotek Pharmaceutical Co., Ltd.

发明人： YAN, Guangmei ,  HU, Haiyan ,  ZHANG, Jingxia ,  QIU, Pengxin ,  LI, Ling ,  TIAN, Ning

IPC分类号： A61K31/565 ,  A61K9/08 ,  A61K9/14 ,  A61K9/19 ,  A61K47/40 ,  A61P9/00 ,  A61P25/00

CPC分类号： A61K47/40 ,  A61K9/0019 ,  A61K31/565 ,  A61K31/568 ,  A61K47/6951 ,  B82Y5/00

摘要： A 5±-androstane-3²,5,6²-triol injection and its preparation are disclosed. The injection uses hydroxypropyl-²-cyclodextrin as a solubilizing agent and the active ingredient is present in a part by weight ratio of 1-20:40-500 to the hydroxypropyl-²-cyclodextrin. The injection may also comprise 1ˆ¼100 parts of an isotonic adjusting agent, 0ˆ¼200 parts of a freeze drying filler, and 0ˆ¼2000 parts of a solvent. The preparation method comprises dissolving hydroxypropyl-²-cyclodextrin solution, 5±-androstane-3²,5,6²-triol and soluble excipients in water for injection in sequence to obtain a raw injection solution, and subjecting the raw injection solution to decolorization, depyrogenation, filtration and sterilization to obtain the injection. Drying the filtrate yields a solid for injection.

公开(公告)号：EP3135288B1

公开(公告)日：2019-01-30

申请号：EP15783742.8

申请日：2015-04-14

申请人： Guangzhou Cellprotek Pharmaceutical Co., Ltd.

发明人： YIN, Wei ,  CHEN, Jiesi ,  YAN, Guangmei ,  LU, Bingzheng ,  ZHU, Wenbo ,  HU, Haiyan ,  QIU, Pengxin ,  HUANG, Yijun ,  ZHANG, Jingxia

IPC分类号： A61K31/56 ,  A61K31/565 ,  A61K31/575 ,  A61P25/00 ,  A61P7/10

公开(公告)号：EP3135288A1

公开(公告)日：2017-03-01

申请号：EP15783742.8

申请日：2015-04-14

申请人： Guangzhou Cellprotek Pharmaceutical Co., Ltd.

发明人： YIN, Wei ,  CHEN, Jiesi ,  YAN, Guangmei ,  LU, Bingzheng ,  ZHU, Wenbo ,  HU, Haiyan ,  QIU, Pengxin ,  HUANG, Yijun ,  ZHANG, Jingxia

IPC分类号： A61K31/56 ,  A61K31/565 ,  A61K31/575 ,  A61P25/00 ,  A61P7/10

CPC分类号： A61K31/56 ,  A61K31/565 ,  A61K31/575

摘要： Use of 5α-androstane-3β,5,6β-triol and analogs thereof in the preparation of a drug for the prophylaxis or treatment of an altitude sickness caused by hypobaric hypoxia is provided, so as to provide a new drug for the prophylaxis or treatment of an altitude sickness. Researches revealed that 5α-androstane-3β,5,6β-triol treatment can effectively reduce vasogenic edema of brain tissue of Macaca fascicularis caused by hypobaric hypoxia, reduce the increased cerebral water content, and protect from neuronal vacuolar degeneration caused by hypobaric hypoxia, therefore it can improve neurological dysfunctions caused by hypobaric hypoxia and is useful in prophylaxis or treatment of an altitude sickness.

摘要翻译： 提供了5± - 雄甾烷-3,2,5,6-二醇及其类似物在制备用于预防或治疗由低压缺氧引起的高原病的药物中的用途，以提供新的药物用于预防或 治疗高原病。 研究结果表明，5± - 雄甾烷-3,2,5,6-二酚治疗可有效降低由低压缺氧引起的猕猴属脑组织的血管性水肿，降低脑水含量，保护低压缺氧引起的神经元空泡变性， 因此可以改善由低压缺氧引起的神经功能障碍，可用于预防或治疗高原病。