公开(公告)号：EP0859641A4

公开(公告)日：1999-05-26

申请号：EP96941959

申请日：1996-10-31

申请人： HARVARD COLLEGE ,  ORGANIX INC ,  MASSACHUSETTS INST TECHNOLOGY

发明人： MELTZER PETER C ,  MADRAS BERTHA K ,  DAVISON ALAN ,  BLUNDELL PAUL ,  MAHMOOD ASHFAQ ,  JONES ALUN G

IPC分类号： A61K51/00 ,  A61K51/04 ,  C07C69/753 ,  C07D451/02 ,  C07F13/00 ,  A61M36/14

CPC分类号： A61K51/0448 ,  A61K2123/00 ,  C07C69/753 ,  C07C2602/44 ,  C07D451/02

摘要： Radiopharmaceutical compounds are disclosed. A tropane compound is linked through the N atom at the 8-position to a chelating ligand capable of complexing technetium or rhenium to produce a neutral labeled complex that selectively binds to the dopamine transporter. These compounds can be prepared as separate diastereoisomers as well as a mixture of diastereoisomers. Also disclosed are radiopharmaceutical kits for preparing the labeled radiopharmaceutical compounds.

摘要翻译： 公开了放射性药物化合物。 托烷化合物通过8-位上的N原子连接到能够络合锝或铼的螯合配体以产生选择性结合多巴胺转运蛋白的中性标记复合物。 这些化合物可以作为单独的非对映异构体以及非对映异构体的混合物制备。 还公开了用于制备标记的放射性药物化合物的放射性药物试剂盒。

公开(公告)号：EP1567495A4

公开(公告)日：2007-10-31

申请号：EP03783254

申请日：2003-11-08

申请人： HARVARD COLLEGE ,  MASSACHUSETTS INST TECHNOLOGY

发明人： MAHMOOD ASHFAQ ,  CHENG ZHEN ,  JONES ALUN G ,  DAVISON ALAN

IPC分类号： C07C323/25 ,  C07C323/41 ,  C07D211/14 ,  C07D211/52 ,  C07D211/56 ,  C07D211/58 ,  C07F13/00 ,  A01N33/02 ,  A01N33/24 ,  A01N37/18 ,  A01N43/40 ,  C07C211/13 ,  C07D211/18 ,  C07D211/32 ,  C07D211/54

CPC分类号： C07C323/41 ,  A61K51/0455 ,  A61K51/0478 ,  C07C323/25 ,  C07D211/14 ,  C07D211/52 ,  C07D211/58 ,  C07F13/005

摘要： The present invention relates to compounds and related technetium and rhenium complexes thereof which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors. In another embodiment, the invention relates the methods of imaging tissues, organs or tumors using radiolabeled metal complexes, particularly tissues, organs, or tumors which express certain receptors to which the compounds or complexes of the invention have an affinity. The present invention also relates to methods of treating cancer, particularly those cancer lines which express certain receptors to which the compounds or complexes of the invention have an affinity. In yet another embodiment, the present invention provides methods of imaging and/or inhibiting receptors or neuroreceptors using compounds or complexes of the invention which have an affinity for the receptor or neuroreceptor to be imaged and/or inhibited.

公开(公告)号：EP2440584A4

公开(公告)日：2015-09-23

申请号：EP10786957

申请日：2010-06-13

申请人： HARVARD COLLEGE

发明人： MAHMOOD ASHFAQ ,  JONES ALUN G ,  LIMPA-AMARA NAENGNOI ,  PENG YIJIE ,  AKGUN ZEYNEP

IPC分类号： C08F4/44 ,  A61K49/00 ,  A61K51/02 ,  A61K51/04 ,  C07C319/00 ,  C07C323/41 ,  C07D211/14 ,  C07D211/22 ,  C07D213/36 ,  C07D333/20 ,  C07D401/12 ,  C07F13/00

CPC分类号： A61K49/0002 ,  A61K51/02 ,  A61K51/04 ,  A61K51/0478 ,  A61K2123/00 ,  C07C323/41 ,  C07C2602/10 ,  C07D211/14 ,  C07D211/22 ,  C07D213/36 ,  C07D333/20 ,  C07D401/12 ,  C07F13/005