公开(公告)号：EP0665836B1

公开(公告)日：1998-04-29

申请号：EP93921924.2

申请日：1993-10-06

申请人： HOECHST AKTIENGESELLSCHAFT

发明人： SCHLOSSER, Hubert ,  WINGEN, Rainer ,  MANERO, Javier

IPC分类号： C07D239/30 ,  C07D213/61 ,  C07D241/16 ,  C07C43/225

CPC分类号： C07D239/30 ,  C07C43/225 ,  C07D213/61 ,  C09K19/2007 ,  C09K19/3444 ,  C09K19/3458 ,  C09K19/3469

摘要： The invention concerns bifunctional compounds of formula (I) in which (a) and (b) are naphthalene-2,6-diyl or (c); (d) is naphthalene-2,6-diyl or (e); U, X, Y, Z are -CH=, -CF= or -N=, with the provision that -CF= or -N= each occur at the most twice in each six-membered ring and that -CF= and -N= do not both occur together twice in a six-membered ring; Hal is Cl, Br or I (or H if X and/or Y are -CF=; R3 is CH¿3? or OCH3; l is 0 or 1 and m and n are 0, 1, 2 or 3. Compounds of formula (I) are useful intermediates in the manufacture of liquid-crystal mixtures.

公开(公告)号：EP0825987A1

公开(公告)日：1998-03-04

申请号：EP96916035.0

申请日：1996-05-10

申请人： HOECHST AKTIENGESELLSCHAFT

发明人： MANERO, Javier ,  WINGEN, Rainer

IPC分类号： G02F1 ,  C07D217 ,  C07D401 ,  C09K19

CPC分类号： C07D401/04 ,  C07D217/22 ,  C09K19/3444

摘要： 1-fluorisoquinoline derivatives of the formula (I) R1(-M1)a(-A1-M2)b(-A2-M3)c-B(-M4-A3)d(-M5-A4)e(-M6)f-R2, in which the symbols and indices have the following meanings: group B is (II); R1, R2 are, for example, alkyl groups with 1-20 C atoms; M?1, M2, M3, M4, M5 and M6¿ are, for example, -O-, -CO-O-, -O-CO- or a single bond; A?1, A2, A3 and A4¿ are, for example, 1,4-phenylene, pyrimidine-2,5-diyl or trans-1,4-cyclohexylene; and a, b, c, d, e and f are 0 or 1, a condition being that the sum of b, c, d and e is 0, 1 or 2. Compounds of formula (I) in the pure state are colourless and as a rule form liquid crystalline mesophases in a temperature range favourable to electro-optical applications. The compounds are chemically and thermally stable and light stable.

公开(公告)号：EP0665825B1

公开(公告)日：1997-01-15

申请号：EP93922520.7

申请日：1993-10-06

申请人： HOECHST AKTIENGESELLSCHAFT

发明人： SCHLOSSER, Hubert ,  WINGEN, Rainer ,  MANERO, Javier

IPC分类号： C07B37/04 ,  C09K19/34 ,  C07D239/26 ,  C07D239/80 ,  C07D213/24 ,  C07D213/61 ,  C07D401/04 ,  C07D401/14

CPC分类号： C07D239/26 ,  C07B37/04 ,  C07D213/61 ,  C07D239/30 ,  C07D401/04 ,  C07D401/14 ,  C09K19/3441 ,  C09K19/3466

摘要： The invention concerns a method of preparing polycyclic aromatic compounds by crosslinking aromatic boron acids with aromatic halogen compounds or perfluoroalkyl sulphonates in the presence of metallic palladium, optionally on a carrier, as catalyst. The method is characterized in that the crosslinking is carried out in the presence of a ligand and a base. The method disclosed enables the yield of polycyclic aromatic compounds to be increased significantly compared with methods in which no ligand is used, i.e. it ensures optimum yields in the pd(O)-catalysed crosslinking of aromatic boron acids with aromatic halogen compounds.

公开(公告)号：EP0665837A1

公开(公告)日：1995-08-09

申请号：EP93921923.0

申请日：1993-10-06

申请人： HOECHST AKTIENGESELLSCHAFT

发明人： SCHLOSSER, Hubert ,  WINGEN, Rainer ,  MANERO, Javier

IPC分类号： C07D239 ,  C07D213 ,  C07D401 ,  C09K19

CPC分类号： C07D239/26 ,  C07D213/65 ,  C07D239/36 ,  C07D401/04 ,  C09K19/3441

摘要： The invention concerns a method of preparing 5-hydroxypyrimidines, 3-, 4- and 5-hydroxypyridines and 4- and 5-hydroxypyridazines from 5-halopyrimidines, 3-, 4- and 5-halopyridines and 4- and 5-halopyridazines. The method is characterized in that the halo-compound is reacted with a metal hydroxide in an inert solvent at atmospheric pressure in the presence of catalytic amounts of sulphur. The reaction takes place both stereoselectively and chemoselectively and gives high yields. No side products (in particular the product in which the halogen atom is replaced by hydrogen) are produced.

摘要翻译： 本发明涉及从5-卤代嘧啶，3-，4-和5-卤代吡啶和4-和5-卤代哒嗪制备5-羟基嘧啶，3-，4-和5-羟基吡啶和4-和5-羟基哒嗪的方法。 该方法的特征在于在催化量的硫存在下，卤代化合物在惰性溶剂中，在常压下与金属氢氧化物反应。 该反应既是立体选择性又是化学选择性的，并且产率高。 没有副产物（特别是其中卤素原子被氢取代的产物）被产生。

公开(公告)号：EP0665825A1

公开(公告)日：1995-08-09

申请号：EP93922520.0

申请日：1993-10-06

申请人： HOECHST AKTIENGESELLSCHAFT

发明人： SCHLOSSER, Hubert ,  WINGEN, Rainer ,  MANERO, Javier

IPC分类号： G02F1 ,  C07B37 ,  C07D213 ,  C07D239 ,  C07D401 ,  C09K19

CPC分类号： C07D239/26 ,  C07B37/04 ,  C07D213/61 ,  C07D239/30 ,  C07D401/04 ,  C07D401/14 ,  C09K19/3441 ,  C09K19/3466

摘要： The invention concerns a method of preparing polycyclic aromatic compounds by crosslinking aromatic boron acids with aromatic halogen compounds or perfluoroalkyl sulphonates in the presence of metallic palladium, optionally on a carrier, as catalyst. The method is characterized in that the crosslinking is carried out in the presence of a ligand and a base. The method disclosed enables the yield of polycyclic aromatic compounds to be increased significantly compared with methods in which no ligand is used, i.e. it ensures optimum yields in the pd(O)-catalysed crosslinking of aromatic boron acids with aromatic halogen compounds.

公开(公告)号：EP0824520B1

公开(公告)日：1999-10-06

申请号：EP96914195.1

申请日：1996-05-10

申请人： HOECHST AKTIENGESELLSCHAFT

发明人： MANERO, Javier ,  WINGEN, Rainer

IPC分类号： C07D217/22 ,  C09K19/34 ,  C07D401/04

CPC分类号： C07D401/04 ,  C07D217/22 ,  C09K19/3444

公开(公告)号：EP0824520A1

公开(公告)日：1998-02-25

申请号：EP96914195.0

申请日：1996-05-10

申请人： HOECHST AKTIENGESELLSCHAFT

发明人： MANERO, Javier ,  WINGEN, Rainer

IPC分类号： G02F1 ,  C07D217 ,  C07D401 ,  C09K19

CPC分类号： C07D401/04 ,  C07D217/22 ,  C09K19/3444

摘要： 1-Fluor-5,6,7,8-tetrahydroisoquinoline derivatives of formula (I) R1(-M1)a(-A1-M2)b(-A2-M3)c-B(M4-A3)d(-M5-A4)e(-M6)f-R2 in which the symbols and indices have following meanings: group B is (II); R1, R2 are, for example, alkyl groups with 1-20 C atoms; M?1, M2, M3, M4, M5 and M6¿ are, for example, -O-, -CO-O, -O-CO- or a single bond; A?1, A2, A3 and A4¿ are, for example, 1,4-phenylene, pyrimidine-2,5-diyl or trans-1,4-cyclohexylene; and a, b, c, d, e and f are 0 or 1, a condition being that the sum of b, c, d and e is 0, 1 or 2. Compounds of formula (I) in the pure state are colourless and as a rule form liquid crystalline mesophases in a temperature range favourable to electro-optical applications. The compounds are chemically and thermally stable and light stable.

公开(公告)号：EP0618914A1

公开(公告)日：1994-10-12

申请号：EP92924707.0

申请日：1992-12-10

申请人： HOECHST AKTIENGESELLSCHAFT

发明人： SCHLOSSER, Hubert ,  WINGEN, Rainer ,  KALTBEITZEL, Anke ,  MANERO, Javier

IPC分类号： C07D303 ,  C07D405 ,  C07K16 ,  C09K19 ,  G02F1

CPC分类号： C07D405/12 ,  C07D405/14 ,  C07K16/2893 ,  C09K19/3405 ,  C09K19/3411 ,  C09K19/3466 ,  C09K19/588 ,  Y10T428/1041

摘要： Des nouveaux oxirannylméthyléthers sont utilisés avantageusement dans des mélanges de cristaux liquides, du fait qu'ils présentent, aux valeurs élevées pour la polarisation spontanée, des éléments de structure dans la molécule, qui les rendent miscibles avec d'autres composants dans les systèmes de cristaux liquides.

公开(公告)号：EP0828716A1

公开(公告)日：1998-03-18

申请号：EP96916033.0

申请日：1996-05-10

申请人： HOECHST AKTIENGESELLSCHAFT

发明人： MANERO, Javier ,  WINGEN, Rainer

IPC分类号： G02F1 ,  C07D217 ,  C07D401 ,  C09K19

CPC分类号： C07D401/04 ,  C07D217/22 ,  C09K19/3444

摘要： 1,8,8-trifluor-5,6,7,8-tetrahydro-isoquinoline derivatives of the formula (I) R1(-M1)a(-A1-M2)b(-A2-M3)c-B(-M4-A3)d(-M5-A4)e(-M6)f-R2, in which the symbols and indices have the following meanings: group B is (II); R1, R2 are, for example, alkyl groups with 1-20 C atoms; M?1, M2, M3, M4, M5 and M6¿ are, for example, -O-, -CO-O-, -O-CO- or a single bond; A?1, A2, A3 and A4¿ are, for example, 1,4-phenylene, pyrimidine-2,5-diyl or trans-1,4-cyclohexylene; and a, b, c, d, e and f are 0 or 1, a condition being that the sum of b, c, d and e is 0, 1 or 2. Compounds of formula (I) in the pure state are colourless and as a rule form liquid crystalline mesophases in a temperature range favourable to electro-optical applications. The compounds are chemically and thermally stable and light stable.

公开(公告)号：EP0824521A1

公开(公告)日：1998-02-25

申请号：EP96916034.0

申请日：1996-05-10

申请人： HOECHST AKTIENGESELLSCHAFT

发明人： MANERO, Javier ,  WINGEN, Rainer

IPC分类号： C07D217 ,  C07D401 ,  C09K19

CPC分类号： C07D401/04 ,  C07D217/22 ,  C09K19/3444

摘要： 1-fluor-6,7-dihydro-5H-isoquinoline-8-one-derivatives of the formula (I) R1(-M1)a(-A1-M2)b(-A2-M3)c-B(-M4-A3)d(-M5-A4)e(-M6)f-R2, in which the symbols and indices have the following meanings: group B is (II); R1, R2 are, for example, alkyl groups with 1-20 C atoms; M?1, M2, M3, M4, M5 and M6¿ are, for example, -O-, -CO-O-, -O-CO- or a single bond; A?1, A2, A3 and A4¿ are, for example, 1,4-phenylene, pyrimidine-2,5-diyl or trans-1,4-cyclohexylene; and a, b, c, d, e and f are 0 or 1, a condition being that the sum of b, c, d and e is 0, 1 or 2. Compounds of formula (I) in the pure state are colourless and as a rule form liquid crystalline mesophases in a temperature range favourable to electro-optical applications. The compounds are chemically and thermally stable and light stable.