公开(公告)号：EP1572874A3

公开(公告)日：2005-12-07

申请号：EP02736661.6

申请日：2002-05-07

申请人： HUMAN GENOME SCIENCES, INC.

发明人： SALCEDO, Theodora ,  RUBEN, Steven, M. ,  ROSEN, Craig, A. ,  ALBERT, Vivian, R. ,  DOBSON, Clarie Louise ,  VAUGHAN, Tristan John

IPC分类号： C12N1/00

公开(公告)号：EP1572874A2

公开(公告)日：2005-09-14

申请号：EP02736661.6

申请日：2002-05-07

申请人： HUMAN GENOME SCIENCES, INC.

发明人： SALCEDO, Theodora ,  RUBEN, Steven, M. ,  ROSEN, Craig, A. ,  ALBERT, Vivian, R. ,  DOBSON, Clarie Louise ,  VAUGHAN, Tristan John

IPC分类号： C12N1/00

CPC分类号： C07K16/30 ,  A61K31/00 ,  A61K39/395 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2878 ,  C07K2317/565 ,  C07K2317/622 ,  A61K2300/00

摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors, and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating, or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.

公开(公告)号：EP1572874B1

公开(公告)日：2013-09-18

申请号：EP02736661.6

申请日：2002-05-07

申请人： Human Genome Sciences, Inc.

发明人： SALCEDO, Theodora ,  RUBEN, Steven M. ,  ROSEN, Craig A. ,  ALBERT, Vivian R. ,  DOBSON, Clarie Louise ,  VAUGHAN, Tristan John

IPC分类号： C07K16/00 ,  C12N5/12 ,  A61P35/00 ,  A61P31/18 ,  A61P43/00 ,  A61K39/42 ,  A61K39/395

CPC分类号： C07K16/30 ,  A61K31/00 ,  A61K39/395 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2878 ,  C07K2317/565 ,  C07K2317/622 ,  A61K2300/00