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    ANTIBODIES THAT SPECIFICALLY BIND TO CHEMOKINE BETA-4
    1.
    发明授权
    ANTIBODIES THAT SPECIFICALLY BIND TO CHEMOKINE BETA-4 有权
    具体趋化因子β-4结合抗体

    公开(公告)号：EP1534752B1

    公开(公告)日：2011-08-03

    申请号：EP03721955.7

    申请日：2003-04-30

    申请人： Human Genome Sciences, Inc.

    发明人： ROSEN, Craig, A. ,  RUBEN, Steven, M.

    IPC分类号： C07K16/00 ,  C07K16/24

    CPC分类号： C07K16/24 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

    摘要： The present invention relates to antibodies and related molecules that specifically bind to CK-B4. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as immune system diseases and disorders including cancers, as well as immune system diseases and disorders including autoimmune diseases, inflammatory disorders, immunodeficiencies, infections, HIV, arthritis, allergy, psoriasis, dermatitis, and inflammatory bowel disease. The invention also relates to nucleic acid molecules encoding anti-CK-B4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancers, as well as immune system diseases and disorders including autoimmune disease, inflammatory disorders, immunodeficiencies, infections, HIV, arthritis, allergy, psoriasis, dermatitis, and inflammatory bowel disease, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to CK-B4.

    ANTIBODIES THAT IMMUNOSPECIFICALLY BIND TO TRAIL RECEPTORS
    7.
    发明公开
    ANTIBODIES THAT IMMUNOSPECIFICALLY BIND TO TRAIL RECEPTORS 审中-公开
    免疫学特异性结合于TRAIL受体的抗体

    公开(公告)号：EP1534336A2

    公开(公告)日：2005-06-01

    申请号：EP03788476.4

    申请日：2003-08-15

    申请人： Human Genome Sciences, Inc.

    发明人： SALCEDO, Theodora ,  RUBEN, Steven, M. ,  ROSEN, Craig, A. ,  ALBERT, Vivian, A.

    IPC分类号： A61K39/395 ,  C07K16/00

    CPC分类号： C07K16/2878 ,  A61K39/39558 ,  A61K2039/505 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92 ,  A61K2300/00

    摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.

    摘要翻译： 本发明涉及免疫特异性结合TRAIL受体TR4的抗体和相关分子。 这样的抗体例如用于预防和治疗癌症和其他增殖性疾病。 本发明还涉及编码抗TR4抗体的核酸分子，包含这些核酸的载体和宿主细胞及其制备方法。 本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是癌症和其它过度增殖性病症的方法和组合物，所述方法和组合物包含向动物，优选人施用有效量的一种或多种抗体或片段 或其变体或相关分子，其免疫特异性结合TRAIL受体TR4。

    ALBUMIN FUSION PROTEINS
    8.
    发明公开
    ALBUMIN FUSION PROTEINS 审中-公开
    ALBUMIN融合蛋白

    公开(公告)号：EP1463752A2

    公开(公告)日：2004-10-06

    申请号：EP02799967.1

    申请日：2002-12-23

    申请人： HUMAN GENOME SCIENCES, INC.

    发明人： ROSEN, Craig, A. ,  HASELTINE, William, A.

    IPC分类号： C07K14/00

    CPC分类号： C07K14/76 ,  C07K14/4713 ,  C07K14/765 ,  C07K2319/00 ,  C12N15/62

    摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating or preventing diseases, disorders or conditions related to diabetes mellitus using albumin fusion proteins of the invention.

    摘要翻译： 本发明包括清蛋白融合蛋白。 编码本发明的清蛋白融合蛋白的核酸分子也包括在本发明中，含有这些核酸的载体，用这些核酸载体转化的宿主细胞以及制备本发明的清蛋白融合蛋白并使用这些核酸的方法 酸，载体和/或宿主细胞。 此外，本发明涵盖包含清蛋白融合蛋白的药物组合物以及使用本发明的清蛋白融合蛋白治疗或预防与糖尿病有关的疾病，病症或病症的方法。

    HUMAN SECRETED PROTEINS
    9.
    发明公开
    HUMAN SECRETED PROTEINS 审中-公开
    人类分泌的蛋白质

    公开(公告)号：EP1379264A1

    公开(公告)日：2004-01-14

    申请号：EP02723499.6

    申请日：2002-03-19

    申请人： Human Genome Sciences, Inc.

    发明人： ROSEN, Craig, A. ,  RUBEN, Steven, M.

    IPC分类号： A61K38/00 ,  C07K1/00

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating gastrointestinal diseases, disorders, and/or conditions related thereto. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

    摘要翻译： 本发明涉及人分泌的多肽和编码所述多肽的分离的核酸分子，可用于诊断和治疗与其相关的胃肠疾病，病症和/或病症。 结合这些多肽的抗体也包含在本发明中。 本发明还包括载体，宿主细胞和用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。