公开(公告)号：EP1992633A1

公开(公告)日：2008-11-19

申请号：EP08001068.9

申请日：1998-11-02

申请人： HUMAN GENOME SCIENCES, INC. ,  Georgetown University Medical Center

发明人： Li, Lu-Yuan ,  Zhai, Yifan ,  Yu, Guo-Liang ,  Ni, Jian ,  Lippman, Marc, E. ,  Rosen, Craig, A.

IPC分类号： C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  A01N43/04 ,  A61K31/70

CPC分类号： C07K14/70575 ,  A61K38/00 ,  C12N2799/026 ,  Y02A50/406

摘要： The present invention relates to a vascular endothelial cell inhibitor, VEGI, capable of inhibiting angiogenesis in cellular models and tumourigenesis in animal models, and methods of use.

摘要翻译： 本发明涉及能够抑制动物模型中细胞模型中的血管生成和肿瘤发生的血管内皮细胞抑制剂VEGI及其使用方法。

公开(公告)号：EP2017337A1

公开(公告)日：2009-01-21

申请号：EP08013946.2

申请日：1995-04-27

申请人： HUMAN GENOME SCIENCES, INC.

发明人： Ni, Jian ,  Gentz, Reiner ,  Rosen, Craig, A.

IPC分类号： C12N15/00 ,  C12N15/11 ,  C12N15/28 ,  C12N15/09 ,  C12N15/63 ,  C07K14/00 ,  C07K14/525 ,  C12P21/06 ,  C12N5/00 ,  C12N5/10 ,  C07K14/715

CPC分类号： C07K14/7151 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026 ,  Y02A50/411

摘要： A human TNF receptor polypeptide and two splice variants thereof and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such receptor polypeptides for screening for antagonists and agonists to the receptors and for ligands for the receptors. Also disclosed are methods for utilizing such agonists to inhibit the growth of tumors, to stimulate cellular differentiation, to mediate the immune response and anti-viral response, to regulate growth and provide resistance to certain infections. The use of the antagonists as a therapeutic to treat autoimmune diseases, inflammation, septic shock, to inhibit graft-host reactions, and to prevent apoptosis is also disclosed. Also disclosed are diagnostic assays for detecting mutations in the nucleic acid sequences and the polypeptides encoded thereby.

摘要翻译： 公开了人TNF受体多肽及其两个剪接变体和编码此类多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种受体多肽筛选受体的受体和激动剂以及受体配体的方法。 还公开了利用这种激动剂抑制肿瘤生长，刺激细胞分化，介导免疫应答和抗病毒应答，调节生长并提供对某些感染的抵抗力的方法。 还公开了拮抗剂作为治疗剂治疗自身免疫性疾病，炎症，败血性休克，抑制移植物宿主反应和预防细胞凋亡的用途。 还公开了用于检测核酸序列中的突变和由此编码的多肽的诊断测定。

公开(公告)号：EP2025682A3

公开(公告)日：2009-06-17

申请号：EP08018826.1

申请日：1996-08-16

申请人： HUMAN GENOME SCIENCES, INC.

发明人： Yu, Guo-Liang ,  Ni, Jian ,  Rosen, Craig, A.

IPC分类号： C12N15/00 ,  C12N1/00 ,  C12P21/06 ,  C07K14/52 ,  C07K1/00 ,  C07H21/04 ,  C07K14/525

CPC分类号： C07K14/5255 ,  A61K38/00 ,  C07K14/52

摘要： The present invention concerns a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular, isolated nucleic acid molecules are provided encoding the endokine alpha protein. Endokine alpha polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic and therapeutic methods concerning TNF family-related disorders.

摘要翻译： 本发明涉及肿瘤坏死因子（TNF）家族细胞因子的新成员。 具体而言，提供了编码内因子α蛋白的分离的核酸分子。 还提供了内因子α多肽，如载体，宿主细胞和用于生产它们的重组方法。 还提供了关于TNF家族相关疾病的诊断和治疗方法。

公开(公告)号：EP1788086A1

公开(公告)日：2007-05-23

申请号：EP07001405.5

申请日：1998-03-17

申请人： HUMAN GENOME SCIENCES, INC.

发明人： Ni, Jian ,  Gentz, Reiner, L. ,  Yu, Guo-Liang ,  Su, Jeffrey, Y. ,  Rosen, Craig, A.

IPC分类号： C12N15/12 ,  C07K14/715 ,  C07K16/28 ,  A61K38/17 ,  A61K39/395 ,  C12N15/62

CPC分类号： C07K14/7151 ,  A61K38/00 ,  C07K2319/00

摘要： The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity.

摘要翻译： 本发明涉及作为肿瘤坏死（TNF）受体家族成员的新的含有死亡域的受体-5（DR5）蛋白，现已显示结合TRAIL。 特别地，提供编码人DR5蛋白的分离的核酸分子。 还提供DR5多肽，载体，宿主细胞以及用于制备其的重组方法。 本发明还涉及用于鉴定DR5活性的拮抗剂和拮抗剂的筛选方法。