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1.发明公开VEGI, an inhibitor of angiogenesis and tumor growth 审中-公开VEGI，ein Hemmstoff der Angiogenese und Tumorwachstum
公开(公告)号：EP1992633A1
公开(公告)日：2008-11-19
申请号：EP08001068.9
申请日：1998-11-02
发明人： Li, Lu-Yuan , Zhai, Yifan , Yu, Guo-Liang , Ni, Jian , Lippman, Marc, E. , Rosen, Craig, A.
CPC分类号： C07K14/70575 , A61K38/00 , C12N2799/026 , Y02A50/406
摘要： The present invention relates to a vascular endothelial cell inhibitor, VEGI, capable of inhibiting angiogenesis in cellular models and tumourigenesis in animal models, and methods of use.
摘要翻译： 本发明涉及能够抑制动物模型中细胞模型中的血管生成和肿瘤发生的血管内皮细胞抑制剂VEGI及其使用方法。
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2.发明公开PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR: A TOOL FOR DETECTION, DIAGNOSIS, PROGNOSIS, AND TREATMENT OF CANCER 审中-公开苯二氮卓PERIFERISCHER型受体：一种手段用于检测，诊断，预后和治疗癌症
公开(公告)号：EP1063997A2
公开(公告)日：2001-01-03
申请号：EP99915033.7
申请日：1999-03-25
IPC分类号： A61K31/55 , A61K39/395 , A61K31/70 , G01N33/574 , G01N33/68 , A61K48/00 , C12N15/12 , C12N15/63 , C12N1/21 , C12N5/08 , C12Q1/02 , C12Q1/48
CPC分类号： G01N33/57415 , A61K31/47 , A61K31/7088 , C07K16/28 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136
摘要： The expression and subcellular localization of peripheral-type benzodiazepine receptors (PBR) is shown in this application to correlate with the metastatic potential of cells, and increased cell proliferation. Inhibition of PBR expression, function or stability results in a decrease in cell proliferation. Compositions and methods for regulating and/or monitoring PBR and its expression are useful for the detection, diagnosis, prognosis and treatment of solid tumors, in particular, breast cancer.
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公开(公告)号：EP0695352A1
公开(公告)日：1996-02-07
申请号：EP94912343.0
申请日：1994-04-07
摘要： DNA sequences encoding cobra C3, CVF1, and CVF2, as well as plasmids and transformed hosts comprising such DNA sequences, are provided.
摘要翻译： 提供了编码眼镜蛇C3，CVF1和CVF2的DNA序列，以及包含这种DNA序列的质粒和转化宿主。
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公开(公告)号：EP1042343B1
公开(公告)日：2008-01-23
申请号：EP98958456.0
申请日：1998-11-02
发明人： LI, Lu-Yuan , ZHAI, Yifan , YU, Guo-Liang , NI, Jian , LIPPMAN, Marc, E. , ROSEN, Craig, A.
CPC分类号： C07K14/70575 , A61K38/00 , C12N2799/026 , Y02A50/406
摘要： The present invention relates to a vascular endothelial cell inhibitor, VEGI, capable of inhibiting angiogenesis in cellular models and tumourigenesis in animal models, and methods of use.
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公开(公告)号：EP1355637A2
公开(公告)日：2003-10-29
申请号：EP01944426.4
申请日：2001-06-12
发明人： LIN, Chen-Yong , DICKSON, Robert, B. , WANG, Shaomeng,University of Michigan , ENYEDY, Istvan , LEE, Sheau-Ling
IPC分类号： A61K31/00
CPC分类号： A61K31/655 , A61K31/155 , A61K31/341 , A61K31/404 , A61K31/505 , A61K49/0002 , G01N33/574 , G01N2333/96486
摘要： The present invention relates to a method of inhibiting carcinoma progression wherein matriptase plays a role in a subject in need of such inhibition including administering to a subject an effective amount of a compound comprising two positively charged groups, which are the same or different. The groups are linked by a chemical group having a length of between 5 and 30 A, and preferably between 15 and 24 A. Diagnostic methods based on matriptase action and therapeutic methods involving inhibition of matriptase activity are provided. Exemplary compounds are pentamidine and analogs thereof.
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公开(公告)号：EP0673438A1
公开(公告)日：1995-09-27
申请号：EP93920497.0
申请日：1993-09-09
发明人： DJAKIEW, Daniel , LEWIS, Michael E.
CPC分类号： G01N33/57434 , C12Q1/6886 , C12Q2600/112 , G01N2333/48 , G01N2333/71
摘要： The invention generally features a method of diagnosing a precancerous or cancerous condition of the prostate gland by monitoring levels of nerve growth factor receptor, or fragments thereof. The invention also features a method of treating a precancerous of cancerous condition of the prostate gland by administering a preparation of nerve growth factor receptor, or a fragment thereof.
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公开(公告)号：EP1129112A2
公开(公告)日：2001-09-05
申请号：EP99912635.2
申请日：1999-03-12
发明人： PAPADOPOULOS, Vassilios , LI, Hua
IPC分类号： C07K14/705 , C12N15/82 , G01N33/68 , C12N15/11
CPC分类号： C12N15/8243 , A61K38/00 , C07K14/705
摘要： Peptides containing a cholesterol interaction/recognition consensus sequence is described and methods of use thereof.
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公开(公告)号：EP1115855A1
公开(公告)日：2001-07-18
申请号：EP99949857.9
申请日：1999-09-23
IPC分类号： C12N15/10 , C12N15/54 , C12N15/81 , C12N1/19 , C07K14/40 , C12N9/12 , C12Q1/48 , G01N33/573 , C07K16/14 , C07K16/40 , C12Q1/68 , A61K35/72 , A61K33/00
CPC分类号： C12N9/1223 , A61K39/00 , C07K14/40
摘要： The present invention relates to nucleic acids encoding a response regulator, CaSsk1p, and methods for use, as well as describes the construction and characterization and use of a Δcassk1 mutant of C. albicans and methods of use.
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公开(公告)号：EP1089734A2
公开(公告)日：2001-04-11
申请号：EP99931870.2
申请日：1999-06-21
发明人： KASID, Usha , SUY, Simeng
IPC分类号： A61K31/445
CPC分类号： A61K31/445 , A61K31/00 , A61K31/454
摘要： A method is provided for inducing cell death comprising administering to said cell a composition comprising tempo or a functional derivative of tempo.
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公开(公告)号：EP1045918A1
公开(公告)日：2000-10-25
申请号：EP99902201.5
申请日：1999-01-12
发明人： FELDER, Robin , JOSE, Pedro
CPC分类号： C07K14/723 , A01K2217/05 , A01K2217/056
摘要： The present invention provides diagnostic tests in which to identify individuals predisposed to essential hypertension, and the genetic, cellular and biochemical tools in which to carry out these tests. The present invention also provides methods of screening substances for anti-hypertensive properties in which to facilitate drug discovery for antihypertensive agents. A wide variety of tools are provided for these purposes as well. The present invention further provides compositions and methods for normalizing sodium transport in kidney cells of individuals having essential hypertension.
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