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公开(公告)号：EP1181599A2
公开(公告)日：2002-02-27
申请号：EP00966686.8
申请日：2000-06-01
CPC分类号： G01J3/02 , G01J3/0218 , G01J3/0232 , G01J3/0291 , G01N21/274 , G01N21/3151 , G01N21/3563 , G02B6/2808 , G02B6/3825 , G02B6/3885 , G02B6/4249 , G02B6/4298
摘要： An optical structure for combining light from a plurality of individual optical fibers into a single optical transmission device. The structure can be incorporated into the optical probe of a spectrophotometric instrument and includes a plurality of optical send fibers (116) having input and output ends and an optical light mixer having input and output ends. The light mixer assembly (110) effectively splices the send fibers (116) to the mixer fiber (152) and includes a connector formed by outer shell (160), inner shell (162), send fiber ferrule (164), mixer fiber ferrule (166) and alignment pin (168). The send fibers (116) extend through the connector outer shell (160) and into send fiber ferrule (164). The ends of the send fibers (116) are secured (e.g., by an optical grade adhesive) in an aperture (170) in the send fiber ferrule (164), cleaved, and polished to provide an optical-quality mating surface. Similarly, the end of the mixer fiber (152) extends through the connector inner shell (162) and into mixer fiber ferrule (166). The end of the mixer fiber (152) is located within an aperture (172) in the mixer fiber ferrule (166).
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公开(公告)号：EP1196762A1
公开(公告)日：2002-04-17
申请号：EP00942866.5
申请日：2000-06-16
发明人： MYERS, Dean, E.
CPC分类号： A61B5/7239 , A61B5/1455 , G01J3/433 , G01N21/35 , G01N21/3504
摘要： A method for operating a spectrophotometric instrument of the type for measuring the oxygenation state of hemoglobin in tissue. The method includes the use of stored hemoglobin concentration relationship data characterizing the relationship between second derivative absorbance values at a hemoglobin-absorbing wavelength and hemoglobin concentration in a tissue as a function of hemoglobin oxygenation state. Data representative of a second derivative absorbance value of tissue being analyzed is received. The hemoglobin oxygenation state of the tissue is determined as a function of the second derivative absorbance value. The hemoglobin concentration in the tissue is then determined as a function of the hemoglobin concentration relationship data, the second derivative absorbance value and the hemoglobin oxygenation state. The accuracy of the hemoglobin oxygenation state can be determined as a function of the hemoglobin concentration value.
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3.发明公开
公开(公告)号：EP1181530A1
公开(公告)日：2002-02-27
申请号：EP00936462.1
申请日：2000-06-01
CPC分类号： G01N21/255 , A61B2560/0223 , A61B2560/0233 , G01J3/02 , G01J3/0218 , G01J3/0232 , G01J3/0291 , G01J3/28 , G01J3/42 , G01J2003/2866 , G01N21/274 , G01N21/3151 , G01N21/3563 , G02B6/4249
摘要： A spectrophotometric instrument including light signal sources, a detector, a processor/controller, a probe and a calibration device. The light signal sources have measurement light wavelengths and a calibration detection wavelength. The probe has one or more send fibers coupled to the measurement and calibration light signal sources for transmitting the light signals into tissue, and one or more receive fibers for receiving light including the measurement light signals and the calibration light signal. The calibration device is adapted to receive the probe and has an optical filter for transmitting the measurement light signals but not the calibration light signal. The detector is coupled to the receive fibers to generate electrical signals representative of the light received at the receive fibers. The processor/controller is coupled to the detector and initiates a calibration procedure when the calibration light signal is not detected.
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公开(公告)号：EP1948019A1
公开(公告)日：2008-07-30
申请号：EP06709701.4
申请日：2006-02-10
IPC分类号： A61B5/1455
CPC分类号： A61B5/14551 , A61B5/0059 , A61B5/0261 , A61B5/0295 , A61B5/412 , A61B5/7239
摘要： A method of analyzing a patient's tissue oxygenation capabilities includes measuring a tissue chromophore whose light absorption properties depend on the oxygenation state of the tissue and generating data representative of tissue oxygenation before, during and after a controlled ischemia event. From this data characterizing data, including ischemia onset slope, ischemia onset response time, ischemia recovery slope, ischemia recovery response time or hyperemia is automatically determined. This characterizing data is related to corresponding characterizing data determined from a control population. The relationship may be displayed on a graphical display.
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公开(公告)号：EP1181530B1
公开(公告)日：2005-06-01
申请号：EP00936462.1
申请日：2000-06-01
CPC分类号： G01N21/255 , A61B2560/0223 , A61B2560/0233 , G01J3/02 , G01J3/0218 , G01J3/0232 , G01J3/0291 , G01J3/28 , G01J3/42 , G01J2003/2866 , G01N21/274 , G01N21/3151 , G01N21/3563 , G02B6/4249
摘要： A spectrophotometric instrument including light signal sources, a detector, a processor/controller, a probe and a calibration device. The light signal sources have measurement light wavelengths and a calibration detection wavelength. The probe has one or more send fibers coupled to the measurement and calibration light signal sources for transmitting the light signals into tissue, and one or more receive fibers for receiving light including the measurement light signals and the calibration light signal. The calibration device is adapted to receive the probe and has an optical filter for transmitting the measurement light signals but not the calibration light signal. The detector is coupled to the receive fibers to generate electrical signals representative of the light received at the receive fibers. The processor/controller is coupled to the detector and initiates a calibration procedure when the calibration light signal is not detected.
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公开(公告)号：EP1180965B1
公开(公告)日：2004-10-13
申请号：EP00939998.1
申请日：2000-06-01
发明人： LEWANDOWSKI, Mark, S. , MYERS, Dean, E. , ORTNER, Joseph, P. , QUAST, Kenneth R. , RUPP, Diane, L. , SCHMIDT, Mark, A.
IPC分类号： A61B5/00
CPC分类号： A61B5/6833 , A61B5/14552 , G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/0291 , G01N21/274 , G01N21/3151 , G02B6/3825 , G02B6/4249 , G02B6/4298
摘要： A disposable tip (100) adapted for use in connection with an optical probe of an instrument. The tip includes a one-piece molded elastomeric base member having a boot (106) and an opaque tissue-engaging surface (108). The boot releasably mates with and provides an interference/friction fit to the probe. The tissue-engaging surface surrounds and extends from the boot. A window (102) in the base member extends into the boot to transmit light between the probe and tissue. A layer of optically transparent material covers the window on the tissue-engaging surface. Adhesive (105) on the tissue-engaging surface of the base member releasably secures the probe to the tissue being analyzed.
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公开(公告)号：EP1181599B1
公开(公告)日：2003-03-05
申请号：EP00966686.8
申请日：2000-06-01
CPC分类号： G01J3/02 , G01J3/0218 , G01J3/0232 , G01J3/0291 , G01N21/274 , G01N21/3151 , G01N21/3563 , G02B6/2808 , G02B6/3825 , G02B6/3885 , G02B6/4249 , G02B6/4298
摘要： An optical structure for combining light from a plurality of individual optical fibers into a single optical transmission device. The structure can be incorporated into the optical probe of a spectrophotometric instrument and includes a plurality of optical send fibers (116) having input and output ends and an optical light mixer having input and output ends. The light mixer assembly (110) effectively splices the send fibers (116) to the mixer fiber (152) and includes a connector formed by outer shell (160), inner shell (162), send fiber ferrule (164), mixer fiber ferrule (166) and alignment pin (168). The send fibers (116) extend through the connector outer shell (160) and into send fiber ferrule (164). The ends of the send fibers (116) are secured (e.g., by an optical grade adhesive) in an aperture (170) in the send fiber ferrule (164), cleaved, and polished to provide an optical-quality mating surface. Similarly, the end of the mixer fiber (152) extends through the connector inner shell (162) and into mixer fiber ferrule (166). The end of the mixer fiber (152) is located within an aperture (172) in the mixer fiber ferrule (166).
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公开(公告)号：EP1948019B1
公开(公告)日：2011-12-07
申请号：EP06709701.4
申请日：2006-02-10
IPC分类号： A61B5/1455
CPC分类号： A61B5/14551 , A61B5/0059 , A61B5/0261 , A61B5/0295 , A61B5/412 , A61B5/7239
摘要： A method of analyzing a patient's tissue oxygenation capabilities includes measuring a tissue chromophore whose light absorption properties depend on the oxygenation state of the tissue and generating data representative of tissue oxygenation before, during and after a controlled ischemia event. From this data characterizing data, including ischemia onset slope, ischemia onset response time, ischemia recovery slope, ischemia recovery response time or hyperemia is automatically determined. This characterizing data is related to corresponding characterizing data determined from a control population. The relationship may be displayed on a graphical display.
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公开(公告)号：EP1988824A2
公开(公告)日：2008-11-12
申请号：EP07757539.7
申请日：2007-02-27
IPC分类号： A61B5/00
CPC分类号： A61B5/14551 , A61B5/412
摘要： Embodiments of the invention provide a method and apparatus for using StO2 values to predict an outcome of a subject's health status.
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公开(公告)号：EP1196762B1
公开(公告)日：2005-11-23
申请号：EP00942866.5
申请日：2000-06-16
发明人： MYERS, Dean, E.
CPC分类号： A61B5/7239 , A61B5/1455 , G01J3/433 , G01N21/35 , G01N21/3504
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