公开(公告)号：EP3006449B1

公开(公告)日：2018-01-31

申请号：EP14801345.1

申请日：2014-03-27

申请人： Hamari Chemicals, Ltd.

发明人： MORIWAKI, Hiroki ,  KAWASHIMA, Aki ,  TAKEDA, Ryosuke ,  KAWAMURA, Akie ,  SOLOSHONOK Vadim A.

IPC分类号： C07F15/04 ,  C07C227/32 ,  C07C229/24 ,  C07C229/30 ,  C07C229/36 ,  C07C229/48 ,  C07C231/18 ,  C07C237/06 ,  C07C319/20 ,  C07C323/58 ,  C07D213/55 ,  C07D223/14 ,  C07B53/00

CPC分类号： C07C227/32 ,  C07B53/00 ,  C07B2200/07 ,  C07C231/18 ,  C07C319/20 ,  C07C2601/02 ,  C07D213/55 ,  C07D223/14 ,  C07F15/045 ,  C07C229/22 ,  C07C229/24 ,  C07C229/30 ,  C07C229/36 ,  C07C229/48 ,  C07C237/08 ,  C07C323/58

摘要： Objects of the present invention are to provide an industrially applicable method for producing an optically active ±-amino acid in high yield and in a highly enantioselective manner, to provide a simple production method of an optically active ±,±-disubstituted ±-amino acid, and to provide an intermediate useful for the above production methods of an optically active ±-amino acid and an optically active ±,±-disubstituted ±-amino acid. The present invention provides a production method of an optically active ±-amino acid or a salt thereof, the production method comprising introducing a substituent into the ± carbon in the ±-amino acid moiety of a metal complex represented by the following Formula (1): by an alkylation reaction, an aldol reaction, the Michael reaction, or the Mannich reaction, and releasing an optically pure ±-amino acid enantiomer or a salt thereof by acid decomposition of the metal complex.

公开(公告)号：EP3006449A1

公开(公告)日：2016-04-13

申请号：EP14801345.1

申请日：2014-03-27

申请人： Hamari Chemicals, Ltd.

发明人： MORIWAKI, Hiroki ,  KAWASHIMA, Aki ,  TAKEDA, Ryosuke ,  KAWAMURA, Akie ,  SOLOSHONOK Vadim A.

IPC分类号： C07F15/04 ,  C07C227/32 ,  C07C229/24 ,  C07C229/30 ,  C07C229/36 ,  C07C229/48 ,  C07C231/18 ,  C07C237/06 ,  C07C319/20 ,  C07C323/58 ,  C07D213/55 ,  C07D223/14 ,  C07B53/00

CPC分类号： C07C227/32 ,  C07B53/00 ,  C07B2200/07 ,  C07C231/18 ,  C07C319/20 ,  C07C2601/02 ,  C07D213/55 ,  C07D223/14 ,  C07F15/045 ,  C07C229/22 ,  C07C229/24 ,  C07C229/30 ,  C07C229/36 ,  C07C229/48 ,  C07C237/08 ,  C07C323/58

摘要： Objects of the present invention are to provide an industrially applicable method for producing an optically active α-amino acid in high yield and in a highly enantioselective manner, to provide a simple production method of an optically active α,α-disubstituted α-amino acid, and to provide an intermediate useful for the above production methods of an optically active α-amino acid and an optically active α,α-disubstituted α-amino acid.
The present invention provides a production method of an optically active α-amino acid or a salt thereof, the production method comprising introducing a substituent into the α carbon in the α-amino acid moiety of a metal complex represented by the following Formula (1):

by an alkylation reaction, an aldol reaction, the Michael reaction, or the Mannich reaction, and releasing an optically pure α-amino acid enantiomer or a salt thereof by acid decomposition of the metal complex.

摘要翻译： 本发明的目的是提供在工业上应用的方法，用于在高产率的光学活性氨基酸和±以高度对映选择性方式制备，以提供光学活性±的简单的制造方法，±二取代的氨基酸± ，并在光学活性的±为光学活性氨基酸的上述制备方法中间体有用和±提供，±二取代氨基酸±。 本发明提供光学活性的氨基酸±或其盐的制造方法，该制造方法包括将取代基引入在± - 氨基由下式表示的金属配合物的±羧酸部分（1） ：通过在烷基化反应，醛醇缩合反应，迈克尔加成反应，或曼尼希反应，和光学纯的氨基酸±对映体或由所述金属络合物的酸分解它们的盐的释放。