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1.发明公开
公开(公告)号：EP3610856A1
公开(公告)日：2020-02-19
申请号：EP19180160.4
申请日：2013-11-06
发明人： KIM, Hyun Uk , LIM, Hyung Kyu , JANG, Myung Hyun , KIM, Sang Yun , BAE, Sung Min , KWON, Se Chang
IPC分类号： A61K9/08 , A61K38/26 , C07K14/605 , A61K39/395 , A61K47/12 , A61K47/26 , A61K9/00 , A61K47/10 , A61K38/22 , A61K47/68
摘要： The present invention relates to an albumin-free liquid formulation comprising a long-lasting oxyntomodulin conjugate in which an oxyntomodulin peptide comprising a derivative, variant, precursor or fragment of oxyntomodulin is linked to an immunoglobulin Fc region, which can increase the duration of physiological activity of the long-lasting oxyntomodulin conjugate and maintain the invivo stability thereof for an extended period of time, as compared to native oxyntomodulin, as well as a method for preparing the liquid formulation. The liquid formulation comprises a buffer, a sugar alcohol and a nonionic surfactant and does not contain a human serum albumin and factors that are potentially harmful to the human body, and thus is not susceptible to viral infection. In addition, the oxyntomodulin conjugate of the invention comprises oxyntomodulin linked to an immunoglobulin Fc region, and thus has a large molecular weight, prolonged physiological activity, and excellent storage stability, compared to native oxyntomodulin.
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公开(公告)号：EP2963056A1
公开(公告)日：2016-01-06
申请号：EP14757629.2
申请日：2014-02-26
发明人： HWANG, Sang Youn , HUH, Yong Ho , KIM, Jin Young , HONG, Sung Hee , CHOI, In Young , JUNG, Sung Youb , KWON, Se Chang , KIM, Dae Jin , KIM, Hyun Uk , JANG, Myung Hyun , KIM, Seung Su
摘要： The present invention relates to an insulin analog that has a reduced insulin titer and a reduced insulin receptor binding affinity compared to the native form for the purpose of increasing the blood half-life of insulin, a conjugate prepared by linking the insulin analog and a carrier, a long-acting formulation including the conjugate, and a method for preparing the conjugate.
摘要翻译： 本发明涉及胰岛素类似物，其与天然形式相比具有降低的胰岛素滴度和降低的胰岛素受体结合亲和力，以增加胰岛素的血液半衰期，通过连接胰岛素类似物和载体制备的缀合物 ，包含缀合物的长效制剂，以及制备缀合物的方法。
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3.发明公开
公开(公告)号：EP2966083A9
公开(公告)日：2016-06-01
申请号：EP14760968.9
申请日：2014-03-05
CPC分类号： A61K38/28 , A61K47/68 , A61K47/6811 , C07K1/1077 , C07K14/62 , C07K2319/30
摘要： The present invention relates to a method for preparing a conjugate by linking a physiologically active polypeptide, a non-peptidyl polymer linker, and an immunoglobulin constant region via a covalent bond. More particularly, the present invention relates to a method for efficiently preparing the physiologically active polypeptide conjugate, in which a salt is used in a coupling reaction to improve the problem of low production yield during preparation of the physiologically active polypeptide conjugate. The complex of physiologically active polypeptide - non-peptidyl polymer - immunoglobulin constant region can be produced with high purity and yield by the preparation method of the present invention. Due to the method for preparing the physiologically active polypeptide conjugate, production costs can be reduced. Therefore, the method can be used to develop long-acting formulations of physiologically active polypeptides, which have improved industrial applicability and drug regulation compliance.
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4.发明公开
公开(公告)号：EP2966083A1
公开(公告)日：2016-01-13
申请号：EP14760968.9
申请日：2014-03-05
CPC分类号： A61K38/28 , A61K47/68 , A61K47/6811 , C07K1/1077 , C07K14/62 , C07K2319/30
摘要： The present invention relates to a method for preparing a conjugate by linking a physiologically active polypeptide, a non-peptidyl polymer linker, and an immunoglobulin constant region via a covalent bond. More particularly, the present invention relates to a method for efficiently preparing the physiologically active polypeptide conjugate, in which a salt is used in a coupling reaction to improve the problem of low production yield during preparation of the physiologically active polypeptide conjugate. The complex of physiologically active polypeptide - non-peptidyl polymer - immunoglobulin constant region can be produced with high purity and yield by the preparation method of the present invention. Due to the method for preparing the physiologically active polypeptide conjugate, production costs can be reduced. Therefore, the method can be used to develop long-acting formulations of physiologically active polypeptides, which have improved industrial applicability and drug regulation compliance.
摘要翻译： 本发明涉及一种方法，用于通过连接生理活性多肽制备缀合物，非肽基聚合物左，并在免疫球蛋白恒定区经由一个共价键。 更具体地，本发明涉及一种用于制备高效生理活性多肽缀合物，其中A盐是在偶联反应中使用制备生理活性多肽偶联物的过程中，以改善问题的低产率的方法。 生理活性多肽的复合物 - 非肽基聚合物 - 免疫球蛋白恒定区可以以高纯度和高产率通过本发明的制备方法来制备。 由于用于制备生理活性多肽偶联物的方法中，生产成本可以降低。 因此，可以使用的方法来开发生理活性多肽，其具有改善的工业实用性和药物法规遵从的长效配方和灰。
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公开(公告)号：EP2963056B1
公开(公告)日：2019-11-13
申请号：EP14757629.2
申请日：2014-02-26
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6.发明公开LIQUID FORMULATION OF PROTEIN CONJUGATE COMPRISING THE OXYNTOMODULIN AND AN IMMUNOGLOBULIN FRAGMENT 审中-公开液体制剂与泌酸调节素蛋白偶联物和免疫球蛋白片段
公开(公告)号：EP2916819A1
公开(公告)日：2015-09-16
申请号：EP13853118.1
申请日：2013-11-06
发明人： KIM, Hyun Uk , LIM, Hyung Kyu , JANG, Myung Hyun , KIM, Sang Yun , BAE, Sung Min , KWON, Se Chang
IPC分类号： A61K9/08 , A61K38/26 , C07K14/605 , A61K39/395
CPC分类号： A61K47/26 , A61K9/0019 , A61K9/08 , A61K38/22 , A61K38/26 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/20 , A61K47/22 , A61K47/68 , A61K47/6811 , A61K47/6851 , C07K14/605 , C07K2319/30
摘要： The present invention relates to an albumin-free liquid formulation comprising a long-lasting oxyntomodulin conjugate in which an oxyntomodulin peptide comprising a derivative, variant, precursor or fragment of oxyntomodulin is linked to an immunoglobulin Fc region, which can increase the duration of physiological activity of the long-lasting oxyntomodulin conjugate and maintain the
invivo stability thereof for an extended period of time, as compared to native oxyntomodulin, as well as a method for preparing the liquid formulation. The liquid formulation comprises a buffer, a sugar alcohol and a nonionic surfactant and does not contain a human serum albumin and factors that are potentially harmful to the human body, and thus is not susceptible to viral infection. In addition, the oxyntomodulin conjugate of the invention comprises oxyntomodulin linked to an immunoglobulin Fc region, and thus has a large molecular weight, prolonged physiological activity, and excellent storage stability, compared to native oxyntomodulin.-
7.发明公开COMPOSITION FOR TREATING HYPERLIPIDEMIA COMPRISING OXYNTOMODULIN DERIVATIVE 审中-公开ZUSAMMENSETZUNG ZUR BEHANDLUNG VONHYPERLIPIDÄMIEMIT EINEM OXYNTOMODULINDERIVAT
公开(公告)号：EP2884994A1
公开(公告)日：2015-06-24
申请号：EP13823727.6
申请日：2013-07-25
发明人： JUNG, Sung Youb , KIM, Jin-Sun , JANG, Myung Hyun , LEE, Sang Hyun , CHOI, In Young , KWON, Se Chang
CPC分类号： A61K38/26 , A61K38/22 , A61K45/06 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/643 , A61K47/6435 , A61K47/68 , A61K47/6811 , C07K14/605 , C07K14/76 , C07K14/78
摘要： The present invention relates to a composition for preventing or treating hyperlipidemia, fatty liver disease or arteriosclerosis, comprising an oxyntomodulin derivative as an active ingredient. The oxyntomodulin derivative has a high ability to activate GLP-1 receptor and glucagon receptor compared to native oxyntomodulin and has the effects of reducing the blood total cholesterol, low-density cholesterol and triglyceride levels that were increased by high-fat diet, and increasing high-density cholesterol levels and the high-density cholesterol/low-density cholesterol ratio. Thus, the oxyntomodulin derivative can be effectively used for the treatment of hyperlipidemia and related diseases.
摘要翻译： 本发明涉及用于预防或治疗高脂血症，脂肪肝疾病或动脉硬化的组合物，其包含胃泌酸调节素衍生物作为活性成分。 胃泌酸调节蛋白衍生物与天然胃泌酸调节素相比具有高活化GLP-1受体和胰高血糖素受体的能力，并且具有降低高脂肪饮食增加的血液总胆固醇，低密度胆固醇和甘油三酯水平的效果，并且增加高 密度胆固醇水平和高密度胆固醇/低密度胆固醇比值。 因此，胃泌酸调节素衍生物可以有效地用于治疗高脂血症和相关疾病。
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公开(公告)号：EP3616727A1
公开(公告)日：2020-03-04
申请号：EP19197388.2
申请日：2014-02-26
发明人： HWANG, Sang Youn , HUH, Yong Ho , KIM, Jin Young , HONG, Sung Hee , CHOI, In Young , JUNG, Sung Youb , KWON, Se Chang , KIM, Dae Jin , KIM, Hyun Uk , JANG, Myung Hyun , KIM, Seung Su
摘要： The present invention relates to an insulin analog that has a reduced insulin titer and a reduced insulin receptor binding affinity compared to the native form for the purpose of increasing the blood half-life of insulin, a conjugate prepared by linking the insulin analog and a carrier, a long-acting formulation including the conjugate, and a method for preparing the conjugate.
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公开(公告)号：EP2966083B1
公开(公告)日：2019-06-05
申请号：EP14760968.9
申请日：2014-03-05
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公开(公告)号：EP2963055B1
公开(公告)日：2019-05-15
申请号：EP14757574.0
申请日：2014-02-26
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