BIDIRECTIONAL SHAPE-MEMORY POLYMER, METHOD OF ITS PRODUCTION AND ITS USE
    4.
    发明授权
    BIDIRECTIONAL SHAPE-MEMORY POLYMER, METHOD OF ITS PRODUCTION AND ITS USE 有权
    双向形状记忆聚合物,方法ITS和使用

    公开(公告)号:EP2935413B1

    公开(公告)日:2016-08-03

    申请号:EP13814153.6

    申请日:2013-12-20

    IPC分类号: C08J3/24 B29C61/00

    摘要: The present invention relates to an article consisting of or comprising a bidirectional shape-memory polymer (bSMP), the bSMP comprising: first phase-segregated domains (AD) having a first transition temperature (Tt,AD) corresponding to a crystallization transition or glass transition of the first domains (AD), second phase-segregated domains (SD) having a second transition temperature (Tt,AD) corresponding to a crystallization transition or glass transition of the second domains (SD), the second transition temperature (Tt,SD) being higher than the first transition temperature (Tt,AD), and covalent or physical bonds cross-linking the polymer chains of the bSMP, and in this way interconnecting the first and second domains (AD, SD), wherein the second phase-separated domains (SD) form a skeleton which is at least partially embedded in the first phase-segregated domains (AD), and wherein polymer chain segments of the bSMP forming the first domains (AD) are substantially orientated in a common direction, such that the bSMP is able to undergo a reversible shape-shift between a first shape (A) at a first temperature (Thigh) and a second shape (B) at a second temperature (Tlow) upon variation of temperature between the first and second temperature (Thigh, Tlow) driven by the crystallization and melting or vitrification and melting of the first phase-separated domains (AD) and without application of an external stress, with Tlow

    VERFAHREN UND KIT ZUR TESTUNG VERSCHIEDENER, AUSGEWÄHLTER WERKSTOFFE UND/ODER OBERFLÄCHENSTRUKTUREN FÜR DIE KULTUR VON ZELLEN
    5.
    发明公开
    VERFAHREN UND KIT ZUR TESTUNG VERSCHIEDENER, AUSGEWÄHLTER WERKSTOFFE UND/ODER OBERFLÄCHENSTRUKTUREN FÜR DIE KULTUR VON ZELLEN 有权
    方法适用于各种,选用材料和/或表面结构用于细胞培养试验

    公开(公告)号:EP2499487A1

    公开(公告)日:2012-09-19

    申请号:EP10768195.9

    申请日:2010-09-24

    IPC分类号: G01N33/50

    CPC分类号: G01N33/5008

    摘要: The invention relates to a method for testing various selected materials and/or surface structures for culturing cells and/or microorganisms, comprising the steps of: i) providing a plurality of various selected materials and/or surface structures to be tested in the form of cup-shaped inserts, wherein the cup-shaped inserts are sized such that a cup-shaped insert can be inserted into a recess of a multi-well plate suitable for cell culturing in a substantially precisely-fit manner, wherein each cup-shaped insert has walls, a floor and an opening on the side facing away from the floor, wherein the walls and floor of the cup-shaped inserts are designed to be fluid-sealed and wherein each cup-shaped insert has one selected material and/or selected surface structure at least on the inner face of the floor; ii) inserting the cup-shaped inserts in recesses of multi-well plates of corresponding sizing such that the exterior side of the cup floor points in the direction of the interior side of the floor of a recess of the multi-well plate; and iii) culturing of cells in the lumen of the cup-shaped inserts. The invention further relatets to a kit for performing said method.

    摘要翻译: 本发明涉及一种用于测试不同的选择的材料和/或表面结构,用于细胞和/或微生物的培养物,所述方法包括以下步骤:i)提供的不同的多个选择的材料和/或表面结构是 在杯形插入的形式,worin所述杯形刀片在寻求一种方式定尺寸测试做了杯形插入件可以插入到基本上准确地设定配合的方式成适合用于细胞培养的多孔板的孔中,worin 每个杯形插入件具有壁,底部,并在开口中从基部背向侧,worin壁和杯形插入的碱是液体密封的,并且worin每个杯形插入已选定的材料 和/或所选择的表面结构中,至少在基部的内表面上; ii)将所述杯形插入到适当的尺寸的多孔板的孔中所以没有向多孔板的孔的底部的内表面上的烧杯基点的外表面; iii)培养所述细胞在杯形插入的内腔,以及一种用于执行这种方法的试剂盒。

    VERFAHREN ZUR EINSCHRITT-PROGRAMMIERUNG VON DREIFORMENKUNSTSTOFFEN
    6.
    发明授权
    VERFAHREN ZUR EINSCHRITT-PROGRAMMIERUNG VON DREIFORMENKUNSTSTOFFEN 有权
    法规划的三个一FORM PLASTICS

    公开(公告)号:EP2121836B1

    公开(公告)日:2011-05-11

    申请号:EP08708142.8

    申请日:2008-01-24

    IPC分类号: C08L67/00

    摘要: The invention relates to a method for producing a programmed shape-memory polymer which assumes a first temporary shape and has at least two further stored, thermally retrievable shapes, to be specific at least a second temporary shape and a permanent shape, with the steps of (a) providing a shape-memory polymer, which comprises at least two switching segments (A, B), which are capable by phase segregation of respectively forming a switching phase with in each case a transition temperature (Ttrans,A, Ttrans,B), (b) deforming the shape-memory polymer into a shape corresponding to the first temporary shape at a temperature above the upper transition temperature (Ttrans,A), and (c) cooling to a temperature below the lower transition temperature (Ttrans,B), thereby fixing the first temporary shape. The method according to the invention provides a one-step programming method for a three-shape plastic.

    SURFACE-FUNCTIONALISED POLYMERIC OBJECT AND METHOD OF ITS PRODUCTION

    公开(公告)号:EP3461857A1

    公开(公告)日:2019-04-03

    申请号:EP17193860.8

    申请日:2017-09-28

    摘要: The invention provides a surface-functionalised polymeric object (10), comprising: a bulk material (11) comprising a copolymer containing constitution units derived from a first comonomer and constitution units derived from a second comonomer, the first comonomer being selected from L-lactide and D-lactide and forming sequences of oligo(L-lactide) or oligo(D-lactide) in the copolymer; and a surface layer (12) disposed on a surface of the bulk material (11), the surface layer (12) comprising a functionalising species and at least one chain of poly(D-lactide) or of poly(L-lactide) covalently bound to the functionalising species, and at least one chain being different from the oligo(L-lactide) sequences or oligo(D-lactide) sequences contained in the copolymer; wherein the surface layer (12) is attached to the bulk material (11) via stereocomplexes formed between the poly(D-lactide) chain(s) of the functionalising species and the oligo(L-lactide) sequences contained in the copolymer or via stereocomplexes formed between the poly(L-lactide) chain(s) of the functionalising species and the oligo(D-lactide) sequences contained in the copolymer, respectively. The surface-functionalised polymeric object can be produced in a one-step procedure by coaxial electrospinning.