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公开(公告)号：EP1455854B1
公开(公告)日：2005-05-25
申请号：EP02804895.7
申请日：2002-12-13
CPC分类号： C12N5/0627 , A61F2/10 , A61L27/24 , A61L27/38 , A61L27/60 , A61L2430/18 , C12N5/0698 , C12N2502/094 , C12N2502/1323
摘要： The invention relates to a skin/hair equivalent, more particularly a hair model with reconstructed papillae (pseudopapillae; PP) in a reconstructed dermis (pseudodermis; PD), to its production and to its use, more particularly for medical/pharmaceutical purposes and for application in the cosmetics industry.
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公开(公告)号：EP1455854A1
公开(公告)日：2004-09-15
申请号：EP02804895.7
申请日：2002-12-13
CPC分类号： C12N5/0627 , A61F2/10 , A61L27/24 , A61L27/38 , A61L27/60 , A61L2430/18 , C12N5/0698 , C12N2502/094 , C12N2502/1323
摘要： The invention relates to a skin/hair equivalent, more particularly a hair model with reconstructed papillae (pseudopapillae; PP) in a reconstructed dermis (pseudodermis; PD), to its production and to its use, more particularly for medical/pharmaceutical purposes and for application in the cosmetics industry.
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公开(公告)号：EP1859272A2
公开(公告)日：2007-11-28
申请号：EP06723191.0
申请日：2006-03-03
发明人： GIESEN, Melanie , PETERSOHN, Dirk , SCHLOTMANN, Kordula , SCHULZE ZUR WIESCHE, Erik , POPPE, Elisabeth
IPC分类号： G01N33/50
CPC分类号： G01N33/5023 , A61K8/44 , A61Q5/00 , A61Q5/12 , A61Q7/00 , G01N33/5038
摘要： The invention relates to: a method for conducting extracorporeal analysis of hair follicle cells; a method for carrying out extracorporeal determination of the ATP synthesis rate in hair follicle cells; a testing method for testing the efficacy of cosmetic or pharmaceutical active substances for maintaining for promoting the homeostasis of the hair follicle or for treating pathogenic conditions of the hair follicle; a screening method for identifying cosmetic or pharmaceutical active substances for maintaining or promoting the homeostasis of the hair follicle or for treating pathogenic conditions of the hair follicle, and; to a method for producing a cosmetic or pharmaceutical preparation for maintaining or promoting the homeostasis of the hair follicle or for treating pathogenic conditions of the hair follicle. The invention also relates to a hair treatment agent containing at least one compound selected from among L-carnitine or L-carnitine derivatives, and to uses thereof, particularly for activating hair metabolism.
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公开(公告)号：EP1222242A1
公开(公告)日：2002-07-17
申请号：EP00971337.1
申请日：2000-10-07
CPC分类号： C11D3/382 , A61K8/19 , A61K8/466 , A61K8/58 , A61K8/64 , A61K8/645 , A61K8/97 , A61K2800/782 , A61Q5/006 , A61Q19/00 , A61Q19/007 , A61Q19/10 , C11D3/042 , C11D3/166 , C11D3/28 , C11D3/349 , C11D3/3719
摘要： The invention relates to cleaning agents which contain inhibitors for the proteases that are involved in breaking down desmosomes. Said inhibitors significantly decrease drying out of the skin caused by surfactants and, as a result, improve the appearance of the skin. Suitable inhibitors are, for example, boric acid and derivatives thereof, 4-(2-aminoethyl)phenylsulfonyl fluoride (Pefabloc® and Pefabloc® SC), the pentapeptide sequence glycine-proline-phenylalanine-proline-leucine, and derivatives which contain this pentapetide sequence, and are rosemary acid as well as the active ingredient Elhibin® that is obtained from leguminous seeds.
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公开(公告)号：EP1658380A2
公开(公告)日：2006-05-24
申请号：EP04764414.1
申请日：2004-08-24
发明人： HOLTKÖTTER, Olaf , PETERSOHN, Dirk , SCHLOTMANN, Kordula , GIESEN, Melanie , KESSLER-BECKER, Daniela
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The invention relates to a method for determining hair cycle markers in vitro, test-kits and biochips which are used to determine hair cycle markers and to the use of proteins, mRNA molecules, protein fragments or mRNA molecules as air cycle markers. The invention also relates to a test method which is used to detect the effectiveness of cosmetic and pharmaceutical active ingredients which influence the hair cycle, in addition to a screening method which is used to identify cosmetic or pharmaceutical active ingredients which influence the hair cycle and to a method for the production of a cosmetic and pharmaceutical preparation which influences the hair cycle.
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公开(公告)号：EP1573053A2
公开(公告)日：2005-09-14
申请号：EP03767789.5
申请日：2003-12-11
发明人： PETERSOHN, Dirk , SCHLOTMANN, Kordula , GASSENMEIER, Thomas , HOLTKÖTTER, Olaf , CONRADT, Marcus , HOFMANN, Kay
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/148 , C12Q2600/158
摘要： The invention relates to a method for determining the homeostasis of hairy skin in vitro, to test kits and biochips for determining markers of hairy skin, in addition to the use of proteins, mRNA molecules or fragments of proteins or mRNA molecules as markers of hairy skin. The invention also relates to a test method for detecting the effectiveness of cosmetic or pharmaceutical active substances for treating hairy skin in addition to a screening method for identifying cosmetic or pharmaceutical active substances for treating hairy skin and to a method for producing a cosmetic or pharmaceutical preparation for treating hairy skin.
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公开(公告)号：EP1222242B1
公开(公告)日：2005-04-20
申请号：EP00971337.1
申请日：2000-10-07
CPC分类号： C11D3/382 , A61K8/19 , A61K8/466 , A61K8/58 , A61K8/64 , A61K8/645 , A61K8/97 , A61K2800/782 , A61Q5/006 , A61Q19/00 , A61Q19/007 , A61Q19/10 , C11D3/042 , C11D3/166 , C11D3/28 , C11D3/349 , C11D3/3719
摘要： The invention relates to cleaning agents which contain inhibitors for the proteases that are involved in breaking down desmosomes. Said inhibitors significantly decrease drying out of the skin caused by surfactants and, as a result, improve the appearance of the skin. Suitable inhibitors are, for example, boric acid and derivatives thereof, 4-(2-aminoethyl)phenylsulfonyl fluoride (Pefabloc® and Pefabloc® SC), the pentapeptide sequence glycine-proline-phenylalanine-proline-leucine, and derivatives which contain this pentapetide sequence, and are rosemary acid as well as the active ingredient Elhibin® that is obtained from leguminous seeds.
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公开(公告)号：EP1573064A2
公开(公告)日：2005-09-14
申请号：EP03789223.9
申请日：2003-12-11
发明人： PETERSOHN, Dirk , SCHLOTMANN, Kordula , GASSENMEIER, Thomas , HOLTKÖTTER, Olaf , CONRADT, Marcus , HOFMANN, Kay
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q2600/148 , C12Q2600/158 , G01N33/6881
摘要： The invention relates to a method for determining the homeostasis of human facial skin in vitro, to test kits and biochips for determining markers of human facial skin, in addition to the use of proteins, mRNA molecules or fragments of proteins or mRNA molecules as markers of human facial skin. The invention also relates to a test method for detecting the effectiveness of cosmetic or pharmaceutical active substances for treating human facial skin in addition to a screening method for identifying cosmetic or pharmaceutical active substances for treating human facial skin and to a method for producing a cosmetic or pharmaceutical preparation for treating human facial skin.
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9.发明授权MAGNESIUM-ANGEREICHERTER EXTRAKT AUS DER BLAUALGE SPIRULINA UND SEINE VERWENDUNG IN KOSMETISCHEN MITTELN ZUR HAUT- UND KÖRPERPFLEGE 有权富含镁提取从蓝绿色的螺旋藻及其用途化妆品中用于皮肤和身体护理
公开(公告)号：EP1239813B1
公开(公告)日：2005-04-13
申请号：EP00989977.4
申请日：2000-12-14
发明人： SCHLOTMANN, Kordula , WALDMANN-LAUE, Marianne , JASSOY, Claudia , KAETEN, Melanie , KÖHLER, Eva-Maria , PULZ, Otto , KURTH, Elke
CPC分类号： A61Q5/00 , A61K8/9706 , A61K33/06 , A61K35/748 , A61Q19/00 , A61Q19/007 , A61Q19/08 , C12N1/12 , A61K2300/00
摘要： The invention relates to an aqueous or aqueous-alcoholic extract of the blue-green algal taxon Spirulina, characterized in that it contains at least 10 wt. % magnesium in relation to the dry weight of said extract. The inventive blue-green alga extract is an efficacious component for stimulating intracellular synthesis of ATP and matrix proteins and differentiation of keratinozytes. The blue-green alga extract is used in topical preparations for cleaning and cosmetic care of the skin and hair, in addition to the production of agents for dermatological treatment of the skin.
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10.发明公开
公开(公告)号：EP1239813A2
公开(公告)日：2002-09-18
申请号：EP00989977.4
申请日：2000-12-14
发明人： SCHLOTMANN, Kordula , WALDMANN-LAUE, Marianne , JASSOY, Claudia , KAETEN, Melanie , KÖHLER, Eva-Maria , PULZ, Otto , KURTH, Elke
CPC分类号： A61Q5/00 , A61K8/9706 , A61K33/06 , A61K35/748 , A61Q19/00 , A61Q19/007 , A61Q19/08 , C12N1/12 , A61K2300/00
摘要： The invention relates to an aqueous or aqueous-alcoholic extract of the blue-green algal taxon Spirulina, characterized in that it contains at least 10 wt. % magnesium in relation to the dry weight of said extract. The inventive blue-green alga extract is an efficacious component for stimulating intracellular synthesis of ATP and matrix proteins and differentiation of keratinozytes. The blue-green alga extract is used in topical preparations for cleaning and cosmetic care of the skin and hair, in addition to the production of agents for dermatological treatment of the skin.
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