公开(公告)号：EP2633870B1

公开(公告)日：2018-08-01

申请号：EP12157470.1

申请日：2012-02-29

Applicant: Technische Universität Berlin

Inventor： Lauster, Roland ,  Binder, Jennifer ,  Rosowski, Mark ,  Marx, Uwe

IPC: A61L27/38

CPC classification number: C12N5/0654 ,  A61K35/32 ,  A61L27/3804 ,  A61L27/3821 ,  A61L27/3865 ,  A61L2430/12 ,  C12N5/0664 ,  C12N2502/094 ,  C12N2506/1361 ,  C12N2513/00 ,  G01N33/5044 ,  G01N33/6887

Abstract: The present invention is directed to a method of preparing an artificial tooth primordium in vitro, comprising the steps: a) providing isolated mesenchymal dental pulp cells; and b) culturing the mesenchymal dental pulp cells under non-adherent conditions to form a cell aggregate representing an artificial tooth primordium; as well as to an artificial tooth primordium derived therefrom.

公开(公告)号：EP3215603A4

公开(公告)日：2018-05-30

申请号：EP15857287

申请日：2015-11-05

Applicant: ORGANOVO INC ,  OREAL

Inventor： RETTING KELSEY NICOLE ,  O'NEILL COLIN M ,  NGUYEN DEBORAH LYNN GREENE ,  PRESNELL SHARON C ,  DEMAUDE JULIEN ,  WU ELIZABETH ,  BALOOCH GUIVE ,  LANGER JESSICA

IPC: C12N5/07 ,  C12N5/0735 ,  C12N5/074 ,  C12N5/078 ,  C12N5/09 ,  C12Q1/02 ,  G01N33/50

CPC classification number: C12N5/0698 ,  C12N2502/091 ,  C12N2502/094 ,  C12N2502/1323 ,  C12N2503/06 ,  C12N2533/54 ,  C12N2533/74 ,  C12N2533/90 ,  C12N2535/00

Abstract: Disclosed are bioprinted, three-dimensional, biological skin tissues comprising: a dermal layer comprising dermal fibroblasts; and an epidermal layer comprising keratinocytes, the epidermal layer in contact with the dermal layer to form the three-dimensional, engineered, biological skin tissue. Also disclosed are arrays of engineered skin tissues and methods of making engineered skin tissues.

公开(公告)号：EP2471902B1

公开(公告)日：2018-05-30

申请号：EP10811319.2

申请日：2010-08-25

Applicant: Servicio Andaluz de Salud ,  Universidad de Granada

Inventor： ALAMINOS MINGORANCE, Miguel ,  MUÑOZ ÁVILA, José Ignacio ,  GONZÁLEZ ANDRADES, Miguel ,  CAMPOS MUÑOZ, Antonio ,  GARZÓN BELLO, Ingrid Johanna

IPC: A61L27/26 ,  A61L27/36 ,  A61L27/38 ,  A61L27/60 ,  A61K35/33 ,  A61K35/36 ,  A61K35/51 ,  C12N5/00 ,  C12N5/073 ,  C12N5/079 ,  C12N5/071

CPC classification number: A61L27/3804 ,  A61K35/33 ,  A61K35/36 ,  A61K35/51 ,  A61L27/26 ,  A61L27/3691 ,  A61L27/3813 ,  A61L27/60 ,  A61L2400/12 ,  A61L2430/16 ,  A61L2430/22 ,  C12N5/0068 ,  C12N5/0605 ,  C12N5/0621 ,  C12N5/0632 ,  C12N5/0684 ,  C12N5/0698 ,  C12N2502/094 ,  C12N2502/1323 ,  C12N2506/025 ,  C12N2533/56 ,  C12N2533/76 ,  C08L89/00 ,  C08L5/12

Abstract: The present invention is encompassed in the field of biomedicine and more specifically tissue engineering. It relates specifically to an in vitro method for preparing an artificial tissue, to the artificial tissue obtainable by said method and to the use of this artificial tissue to partially or completely increase, restore or replace the functional activity of a damaged tissue or organ.

公开(公告)号：EP2582791B8

公开(公告)日：2018-05-23

申请号：EP11796538.4

申请日：2011-06-17

Applicant: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.

Inventor： THANGAPAZHAM, Rajesh ,  DARLING, Thomas, N. ,  LI, Shaowei

IPC: A61L27/24 ,  A61L27/38 ,  A61L27/60 ,  C12N5/071 ,  A61F2/10 ,  A61K35/36

CPC classification number: A61L27/3886 ,  A61F2/105 ,  A61K35/36 ,  A61L27/24 ,  A61L27/3813 ,  A61L27/3834 ,  A61L27/60 ,  A61L2430/18 ,  C12N5/0627 ,  C12N5/0698 ,  C12N2501/04 ,  C12N2501/998 ,  C12N2502/092 ,  C12N2502/094 ,  C12N2502/1323 ,  C12N2502/30 ,  C12N2510/00 ,  C12N2533/78

Abstract: This invention provides a skin substitute comprising epithelial cells and modified mesenchymal cells, wherein the modified mesenchymal cells have decreased TSC1/TSC2 function, increased mTORCI function, and/or decreased mTORC2 function compared to wild type mesenchymal cells, and methods for using the same. This invention also provides a method for transplanting cells capable of inducing hair follicles, comprising subdermally or intradermally delivering to a patient modified mesenchymal cells, wherein the modified mesenchymal cells have decreased TSC1/TSC2 function, increased mTORCI function, and/or decreased mTORC2 function compared to wild type mesenchymal cells.

公开(公告)号：EP3274005A1

公开(公告)日：2018-01-31

申请号：EP16713834.6

申请日：2016-03-25

Applicant: Université de Bordeaux ,  Inserm ,  Centre Hospitalier Universitaire de Bordeaux

Inventor： CASOLI, Vincent ,  CARIO-ANDRÉ, Muriel ,  LEPIVERT, Jean-Christophe

IPC: A61L27/24 ,  A61L27/60 ,  A61L27/38 ,  A61F2/10 ,  C12N5/00

CPC classification number: C12N5/0698 ,  A61K35/35 ,  A61K35/36 ,  A61L27/24 ,  A61L27/3804 ,  A61L27/3813 ,  A61L27/3886 ,  A61L27/60 ,  A61P17/02 ,  A61P35/00 ,  C12N2500/32 ,  C12N2500/38 ,  C12N2501/905 ,  C12N2502/091 ,  C12N2502/094 ,  C12N2502/1323 ,  C12N2533/54

Abstract: The present invention relates to a method for preparing a skin substitute, to a method for preparing a dermal substitute, to a skin substitute, to a dermal substitute and to a kit for implementing the method. The present invention also relates to a graft consisting of a skin substitute and to the use thereof as a means of treating a skin disorder and/or a loss of skin substance. The present invention can be used in particular in the pharmacological, medical and clinical fields.

公开(公告)号：EP3215603A1

公开(公告)日：2017-09-13

申请号：EP15857287.5

申请日：2015-11-05

Applicant: Organovo, Inc. ,  L'Oréal

Inventor： RETTING, Kelsey Nicole ,  O'NEILL, Colin M. ,  NGUYEN, Deborah Lynn Greene ,  PRESNELL, Sharon C. ,  DEMAUDE, Julien ,  WU, Elizabeth ,  BALOOCH, Guive ,  LANGER, Jessica

IPC: C12N5/07 ,  C12N5/0735 ,  C12N5/074 ,  C12N5/078 ,  C12N5/09 ,  C12Q1/02 ,  G01N33/50

CPC classification number: C12N5/0698 ,  C12N2502/091 ,  C12N2502/094 ,  C12N2502/1323 ,  C12N2503/06 ,  C12N2533/54 ,  C12N2533/74 ,  C12N2533/90 ,  C12N2535/00

Abstract: Disclosed are bioprinted, three-dimensional, biological skin tissues comprising: a dermal layer comprising dermal fibroblasts; and an epidermal layer comprising keratinocytes, the epidermal layer in contact with the dermal layer to form the three-dimensional, engineered, biological skin tissue. Also disclosed are arrays of engineered skin tissues and methods of making engineered skin tissues.

Abstract translation: 公开了生物打印的三维生物皮肤组织，包括：包含真皮成纤维细胞的真皮层; 以及包含角质形成细胞的表皮层，所述表皮层与真皮层接触以形成三维工程化生物皮肤组织。 还公开了工程皮肤组织的阵列和制造工程皮肤组织的方法。

公开(公告)号：EP2035550B1

公开(公告)日：2016-07-27

申请号：EP07795998.9

申请日：2007-06-12

Applicant: Sanofi Pasteur VaxDesign Corporation

Inventor： WARREN, William, L. ,  HIGBEE, Russell ,  MISHKIN, Eric ,  SANCHEZ-SCHMITZ, Guzman ,  FAHLENKAMP, Heather ,  RIVARD, Michael

IPC: C12M3/00 ,  C12M1/12 ,  C12M1/42 ,  G01N33/50 ,  C12N5/078 ,  C12N5/077

CPC classification number: C12M21/08 ,  C12M25/14 ,  C12M35/08 ,  C12N5/0697 ,  C12N2501/21 ,  C12N2502/091 ,  C12N2502/094 ,  C12N2502/11 ,  C12N2502/28 ,  C12N2502/30 ,  C12N2503/04 ,  C12N2531/00 ,  C12N2533/50 ,  C12N2533/54 ,  C12N2535/10 ,  G01N33/5044 ,  G01N33/5064 ,  G01N33/5082 ,  G01N33/5088 ,  G01N2800/24

公开(公告)号：EP2103687B1

公开(公告)日：2016-07-13

申请号：EP09155394.1

申请日：2009-03-17

Applicant: L'Oréal

Inventor： Duval, Christine ,  Bernerd, Françoise

IPC: C12N5/071 ,  G01N33/50

CPC classification number: C12N5/0698 ,  C12N2501/11 ,  C12N2501/117 ,  C12N2501/39 ,  C12N2502/091 ,  C12N2502/094 ,  C12N2502/1323 ,  C12N2533/50 ,  C12N2533/52 ,  C12N2533/54 ,  G01N33/5088

公开(公告)号：EP2302035B1

公开(公告)日：2016-05-11

申请号：EP10012359.5

申请日：2003-03-03

Applicant: UNIVERSITY OF CINCINNATI ,  Shriners Hospitals for Children

Inventor： Boyce, Steven T.

IPC: A61F2/10 ,  A61L27/38 ,  A61L27/60 ,  A61P17/02 ,  C12N5/071

CPC classification number: A61F2/105 ,  A61L27/3804 ,  A61L27/3886 ,  A61L27/3895 ,  A61L27/60 ,  C12N5/0698 ,  C12N2502/094 ,  C12N2502/1323

公开(公告)号：EP2936984A1

公开(公告)日：2015-10-28

申请号：EP15169507.9

申请日：2004-04-29

Applicant: Medgenics, Inc.

Inventor： Bellomo, Stephen, F. ,  Lippin, Itzhak ,  Piva, Guillermo, Alberto ,  Rosenberg, Lior ,  Bukhman, Mordechay ,  Stern, Baruch, S. ,  Shalhevet, David ,  Shavitt, Menachem, D. ,  Pearlman, Andrew, L. ,  Noam, Shani ,  Almon, Einat

IPC: A01N63/00 ,  A01N65/00 ,  C12N5/00 ,  C12N5/02 ,  C12N5/071

CPC classification number: A61B17/3468 ,  A61B10/0275 ,  A61B17/32053 ,  A61B17/322 ,  A61B2017/0023 ,  A61B2017/00969 ,  A61B2017/2808 ,  A61B2017/320052 ,  A61B2017/320064 ,  A61B2017/3225 ,  A61B2217/005 ,  A61F2/105 ,  A61K35/36 ,  A61K38/1816 ,  A61K38/193 ,  A61K38/2066 ,  A61K38/215 ,  A61K38/27 ,  A61K38/28 ,  A61M5/425 ,  C12N5/0698 ,  C12N2502/094 ,  C12N2502/1323 ,  C12N2510/00 ,  Y10T83/929

Abstract: The present invention is directed to an apparatus for harvesting a dermal micro-organ. In particular, the apparatus comprises a support configuration to support a skin-related tissue structure from which said dermal micro-organ is to be harvested and a cutting tool able to separate said dermal micro-organ from said skin-related tissue structure. The present invention is also directed to a method for harvesting a dermal micro-organ. In particular, the method comprises supporting a skin-related tissue structure from which said dermal micro-organ is harvested and separating said dermal micro-organ from said skin-related tissue structure.

Abstract translation: 本发明涉及一种用于收获真皮微器官的装置。 特别地，该装置包括支撑构造以支撑要收获所述真皮微器官的与皮肤相关的组织结构，以及能够将所述真皮微器官与所述皮肤相关组织结构分离的切割工具。 本发明还涉及一种用于收获真皮微器官的方法。 特别地，该方法包括支撑与皮肤相关的组织结构，所述皮肤微器官从该皮肤组织结构被收获并从所述与皮肤相关的组织结构分离所述真皮微器官。