公开(公告)号：EP3907235A1

公开(公告)日：2021-11-10

申请号：EP19891727.0

申请日：2019-10-31

申请人： HiPep Laboratories

发明人： NOKIHARA, Kiyoshi ,  TOMINAGA, Yuki ,  KITAGAWA, Atsushi ,  NOKIHARA, Shun

IPC分类号： C07K7/06 ,  A61K38/08 ,  A61K38/12

摘要： Disclosed are a novel compound having a higher angiogenic effect than that of a known peptide-based angiogenic agent, and an angiogenic agent including the novel compound. The compound is represented by the following formula [I]: Cyclic(Cys-O2Oc-SVV(F/Y)GLRG-Cys)-NH 2 (wherein the number of oxyethylene units, represented by 020c, is within the range of 2 to 6), the following formula [II]: Cyclic(O 2 Oc-SVV(F/Y)GLRQ)-NH 2 [II] (wherein the number of oxyethylene units, represented by O2Oc, is within the range of 2 to 6), or the following formula [III]: O 2 Oc-SVV(F/Y)GLR-NH 2 [III] (wherein the number of oxyethylene units, represented by 020c, is within the range of 2 to 6).