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9 条记录 (耗时 0.013 秒)

    ANTIOXIDANT AGENT
    1.
    发明公开
    ANTIOXIDANT AGENT 审中-公开
    抗氧化剂

    公开(公告)号：EP2407165A1

    公开(公告)日：2012-01-18

    申请号：EP10750900.2

    申请日：2010-03-11

    申请人： HiPep Laboratories

    发明人： NOKIHARA, Kiyoshi ,  MIYAZATO, Naeko

    IPC分类号： A61K31/4412 ,  A61K8/49 ,  A61K8/64 ,  A61K36/00 ,  A61K38/00 ,  A61P9/00 ,  A61P17/00 ,  A61P17/18 ,  A61P35/00 ,  A61P39/06 ,  A61Q19/02

    CPC分类号： A61K31/4412 ,  A61K8/4926 ,  A61K8/64 ,  A61K38/00 ,  A61K2800/522 ,  A61Q19/02 ,  C07K5/0808 ,  C07K5/0812 ,  C07K5/0817 ,  C07K5/0821 ,  C07K5/0823 ,  C07K5/1024

    摘要： Disclosed is an antioxidant which can exhibit a higher antioxidant ability than known antioxidative peptides. The antioxidant according to the present invention comprises mimosine and/or a mimosine-containing pcptide(s). The mimosine-containing peptide is a peptide which comprises at least one mimosine residue in its amino acid sequence. Mimosine has stronger antioxidant potency than known antioxidative tripeptides even when used as it is alone, and therefore is useful as an antioxidant. In addition, the antioxidant action of a peptide can be increased by introducing mimosine thereinto, thereby obtaining a peptide with higher antioxidant potency than the original one.

    摘要翻译： 公开了一种抗氧化剂，其可以表现出比已知抗氧化肽更高的抗氧化能力。 根据本发明的抗氧化剂包含mimosine和/或含mimosine的肽。 含mimosine的肽是在其氨基酸序列中包含至少一个mimosine残基的肽。 即使单独使用，含莫米辛比已知的抗氧化三肽具有更强的抗氧化效力，因此可用作抗氧化剂。 此外，通过将霉素引入其中，可以增加肽的抗氧化作用，由此获得具有比原始效价更高的抗氧化效力的肽。

    BIOCHIP SUBSTRATE AND BIOCHIP
    4.
    发明公开
    BIOCHIP SUBSTRATE AND BIOCHIP 有权
    生物芯片衬底和生物芯片

    公开(公告)号：EP2006679A2

    公开(公告)日：2008-12-24

    申请号：EP06766807.9

    申请日：2006-06-16

    申请人： HiPep Laboratories ,  Nippon Light Metal Company Ltd.

    发明人： NOKIHARA, Kiyoshi ,  OKA, Yasuo

    IPC分类号： G01N33/53 ,  C12M1/00 ,  C12N15/09 ,  G01N33/543 ,  G01N33/547 ,  G01N37/00

    CPC分类号： G01N33/54393 ,  B01L3/5085 ,  B01L2200/12 ,  B01L2300/0636 ,  B01L2300/0829 ,  B01L2300/0893 ,  B01L2300/0896 ,  B01L2300/12 ,  B82Y30/00 ,  C40B60/14

    摘要： A substrate for biochips with which spots are not diffused and cross-contamination due to contacts between adjacent spots does not occur, as well as a biochip using the substrate, is disclosed. A substrate for biochips with which spots are not diffused and cross-contamination due to contacts between adjacent spots does not occur, by forming a plurality of recesses for immobilizing biologically relevant substances, as well as a biochip using the substrate, was provided. It was discovered also that the desired binding of target molecules in a test sample occurs at a detectable level in solution systems even if the volume of each recess is extremely small as small as 1 nL to 10 nL.

    摘要翻译： 公开了一种用于生物芯片的基板，该基板不会发生点扩散，并且由于相邻点之间的接触而不会发生交叉污染，以及使用该基板的生物芯片。 通过形成多个用于固定生物相关物质的凹槽以及使用该基板的生物芯片，提供了一种用于生物芯片的基板，该基板不会发生斑点扩散并且由于相邻斑点之间的接触而不会发生交叉污染。 还发现，即使每个凹槽的体积非常小（小至1nL至10nL），测试样品中目标分子的期望结合在溶液系统中以可检测的水平发生。

    NOVEL COMPOUND AND ANGIOGENIC AGENT COMPRISING SAME
    6.
    发明公开
    NOVEL COMPOUND AND ANGIOGENIC AGENT COMPRISING SAME 审中-公开

    公开(公告)号：EP3907235A1

    公开(公告)日：2021-11-10

    申请号：EP19891727.0

    申请日：2019-10-31

    申请人： HiPep Laboratories

    发明人： NOKIHARA, Kiyoshi ,  TOMINAGA, Yuki ,  KITAGAWA, Atsushi ,  NOKIHARA, Shun

    IPC分类号： C07K7/06 ,  A61K38/08 ,  A61K38/12

    摘要： Disclosed are a novel compound having a higher angiogenic effect than that of a known peptide-based angiogenic agent, and an angiogenic agent including the novel compound. The compound is represented by the following formula [I]: Cyclic(Cys-O2Oc-SVV(F/Y)GLRG-Cys)-NH 2 (wherein the number of oxyethylene units, represented by 020c, is within the range of 2 to 6), the following formula [II]: Cyclic(O 2 Oc-SVV(F/Y)GLRQ)-NH 2 [II] (wherein the number of oxyethylene units, represented by O2Oc, is within the range of 2 to 6), or the following formula [III]: O 2 Oc-SVV(F/Y)GLR-NH 2 [III] (wherein the number of oxyethylene units, represented by 020c, is within the range of 2 to 6).

    BIOCHIP SUBSTRATUM AND METHOD FOR PRODUCTION THEREOF
    7.
    发明公开
    BIOCHIP SUBSTRATUM AND METHOD FOR PRODUCTION THEREOF 有权
    BIOCHIP-SUBSTRAT UND VERFAHREN ZUR HERSTELLUNG DAVON

    公开(公告)号：EP2306197A1

    公开(公告)日：2011-04-06

    申请号：EP09773454.5

    申请日：2009-06-30

    申请人： HiPep Laboratories ,  Nippon Light Metal, Co., Ltd.

    发明人： NOKIHARA, Kiyoshi ,  HIRATA, Akiyoshi ,  OKA, Yasuo ,  TAKEBAYASHI, Yasushi

    IPC分类号： G01N33/543 ,  C12N15/09 ,  G01N33/545 ,  G01N33/551 ,  G01N37/00

    CPC分类号： G01N33/545 ,  B01J2219/00527 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01L3/50 ,  C08J3/28 ,  C12Q1/6837 ,  G01N33/54353 ,  G01N33/54393 ,  Y10T428/273

    摘要： A substrate for biochips which has a high probe loading amounts and a uniform immobilization density, and which further has a high detection sensitivity and a high reproducibility by preventing a non-specific adsorption of proteins, when used as a substrate for biochips for immobilizing probes composed of biologically relevant substances such as proteins and nucleic acids, is disclosed. Amino groups can be bound to the surface of the substrate uniformly, at a high density and stably by covalently immobilizing an amino group-containing polymer on the surface of the substrate. The probe immobilization rate is high and immobilizing density was uniform by immobilizing a probe composed of a biologically relevant substance such as a protein or nucleic acid by utilizing the amino groups. Further, detection sensitivity and reproducibility are high by inhibiting non-specific adsorption of proteins.

    摘要翻译： 用于生物芯片的基底，其具有高的探针加载量和均匀的固定密度，并且当用作用于固定探针的生物芯片的基底时，其进一步具有高的检测灵敏度和通过防止蛋白质的非特异性吸附而具有高的再现性 的生物相关物质如蛋白质和核酸。 氨基可以通过将含氨基的聚合物共价固定在基材的表面上，以高密度和稳定地均匀地结合到基材的表面。 探针固定化率高，固定化密度均匀，通过利用氨基固定由生物相关物质如蛋白质或核酸组成的探针。 此外，通过抑制蛋白质的非特异性吸附，检测灵敏度和再现性高。