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13 条记录 (耗时 0.01 秒)

    ANTIOXIDANT AGENT
    1.
    发明公开
    ANTIOXIDANT AGENT 审中-公开
    抗氧化剂

    公开(公告)号：EP2407165A1

    公开(公告)日：2012-01-18

    申请号：EP10750900.2

    申请日：2010-03-11

    申请人： HiPep Laboratories

    发明人： NOKIHARA, Kiyoshi ,  MIYAZATO, Naeko

    IPC分类号： A61K31/4412 ,  A61K8/49 ,  A61K8/64 ,  A61K36/00 ,  A61K38/00 ,  A61P9/00 ,  A61P17/00 ,  A61P17/18 ,  A61P35/00 ,  A61P39/06 ,  A61Q19/02

    CPC分类号： A61K31/4412 ,  A61K8/4926 ,  A61K8/64 ,  A61K38/00 ,  A61K2800/522 ,  A61Q19/02 ,  C07K5/0808 ,  C07K5/0812 ,  C07K5/0817 ,  C07K5/0821 ,  C07K5/0823 ,  C07K5/1024

    摘要： Disclosed is an antioxidant which can exhibit a higher antioxidant ability than known antioxidative peptides. The antioxidant according to the present invention comprises mimosine and/or a mimosine-containing pcptide(s). The mimosine-containing peptide is a peptide which comprises at least one mimosine residue in its amino acid sequence. Mimosine has stronger antioxidant potency than known antioxidative tripeptides even when used as it is alone, and therefore is useful as an antioxidant. In addition, the antioxidant action of a peptide can be increased by introducing mimosine thereinto, thereby obtaining a peptide with higher antioxidant potency than the original one.

    摘要翻译： 公开了一种抗氧化剂，其可以表现出比已知抗氧化肽更高的抗氧化能力。 根据本发明的抗氧化剂包含mimosine和/或含mimosine的肽。 含mimosine的肽是在其氨基酸序列中包含至少一个mimosine残基的肽。 即使单独使用，含莫米辛比已知的抗氧化三肽具有更强的抗氧化效力，因此可用作抗氧化剂。 此外，通过将霉素引入其中，可以增加肽的抗氧化作用，由此获得具有比原始效价更高的抗氧化效力的肽。

    SUBSTRATE FOR BIOCHIP AND BIOCHIP
    2.
    发明公开
    SUBSTRATE FOR BIOCHIP AND BIOCHIP 有权
    BIOCHIPSUBSTRAT UND BIOCHIP

    公开(公告)号：EP1887364A1

    公开(公告)日：2008-02-13

    申请号：EP06756519.2

    申请日：2006-05-24

    申请人： HiPep Laboratories ,  Nippon Light Metal, Co., Ltd.

    发明人： NOKIHARA, Kiyoshi 7-115, Fuujiyama-cho ,  OKA, Yasuo

    IPC分类号： G01N37/00 ,  C12M1/00 ,  C12N15/09 ,  G01N33/53 ,  G01N33/547 ,  G01N33/553

    CPC分类号： G01N33/553 ,  B01J19/0046 ,  B01J2219/00387 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00677 ,  B01J2219/00722 ,  B01J2219/00725 ,  G01N33/54353 ,  G01N33/551 ,  Y10T428/31678

    摘要： A substrate for biochips with which immobilization is easy, which does not exhibit self-fluorescence, which is easy to manufacture, and which is excellent in flatness and surface precision, is disclosed. A substrate having a substrate body of the biochip, which is made of a metal, and a carbon layer having functional groups formed on the metal substrate body is used as a substrate for biochips. Since the substrate body of the substrate for biochips is made of a metal, the substrate is not only easy to manufacture, but also free from cracking and chipping, so that it allows easy handling, and high flatness and surface precision can be attained. Therefore, the problem that the optical system is hard to focus when detecting fluorescence does not occur. Moreover, since the substrate body is made of a metal, it does not emit fluorescence by itself. In addition, since the carbon layer has functional groups such as amino groups, biologically relevant substances can be easily immobilized.

    摘要翻译： 公开了一种容易制造的生物芯片的基板，其固定化容易，不具有自发荧光，易于制造，平坦度和表面精度优异。 作为生物芯片的基板，使用具有由金属制成的生物芯片的基板主体和具有形成在金属基板主体上的官能团的碳层的基板。 由于用于生物芯片的基板的基板由金属制成，所以基板不仅容易制造，而且没有破裂和碎裂，从而易于处理，并且可以获得高平坦度和表面精度。 因此，不发生检测荧光时光学系统难以聚焦的问题。 此外，由于基板主体由金属制成，它本身不会发出荧光。 此外，由于碳层具有诸如氨基的官能团，所以可以容易地固定生物相关的物质。

    Peptide-immobilized substrate and method for measuring target protein using the same
    4.
    发明公开
    Peptide-immobilized substrate and method for measuring target protein using the same 审中-公开
    Peptidimmobilisiertes Substrat und Verfahren zum Messen eines Zielproteins damit

    公开(公告)号：EP1914550A1

    公开(公告)日：2008-04-23

    申请号：EP07020589.3

    申请日：2002-05-07

    申请人： HiPep Laboratories

    发明人： Nokihara, Kiyoshi ,  Mihara, Hisakazu

    IPC分类号： G01N33/542 ,  G01N33/58

    CPC分类号： C40B30/04 ,  C07K1/1077 ,  C07K14/00 ,  G01N33/6845

    摘要： Disclosed is a peptide-immobilized substrate for measuring a target protein, with which the peptide can have a structure required for being recognized by the target protein, with which the accurate loading amount of the peptide can be attained, and by which a trace amount of the target protein may be measured accurately and simply. The peptide-immobilized substrate for measuring a target protein according to the present invention comprises a chemicarlly synthesized peptide having an expected spatial structure or having a binding ability with the target protein, which peptide can bind with the target protein and is immobilized on the substrate.

    摘要翻译： 公开了用于测定靶蛋白质的肽固定化基质，肽可以具有被靶蛋白识别所需的结构，能够获得肽的精确负载量，并且通过其 可以准确且简单地测量靶蛋白。 根据本发明的用于测量靶蛋白的肽固定化底物包含具有预期空间结构或具有与靶蛋白结合能力的化学合成肽，该肽可与靶蛋白结合并固定在基底上。

    BIOCHIP SUBSTRATE AND BIOCHIP
    7.
    发明公开
    BIOCHIP SUBSTRATE AND BIOCHIP 有权
    生物芯片衬底和生物芯片

    公开(公告)号：EP2006679A2

    公开(公告)日：2008-12-24

    申请号：EP06766807.9

    申请日：2006-06-16

    申请人： HiPep Laboratories ,  Nippon Light Metal Company Ltd.

    发明人： NOKIHARA, Kiyoshi ,  OKA, Yasuo

    IPC分类号： G01N33/53 ,  C12M1/00 ,  C12N15/09 ,  G01N33/543 ,  G01N33/547 ,  G01N37/00

    CPC分类号： G01N33/54393 ,  B01L3/5085 ,  B01L2200/12 ,  B01L2300/0636 ,  B01L2300/0829 ,  B01L2300/0893 ,  B01L2300/0896 ,  B01L2300/12 ,  B82Y30/00 ,  C40B60/14

    摘要： A substrate for biochips with which spots are not diffused and cross-contamination due to contacts between adjacent spots does not occur, as well as a biochip using the substrate, is disclosed. A substrate for biochips with which spots are not diffused and cross-contamination due to contacts between adjacent spots does not occur, by forming a plurality of recesses for immobilizing biologically relevant substances, as well as a biochip using the substrate, was provided. It was discovered also that the desired binding of target molecules in a test sample occurs at a detectable level in solution systems even if the volume of each recess is extremely small as small as 1 nL to 10 nL.

    摘要翻译： 公开了一种用于生物芯片的基板，该基板不会发生点扩散，并且由于相邻点之间的接触而不会发生交叉污染，以及使用该基板的生物芯片。 通过形成多个用于固定生物相关物质的凹槽以及使用该基板的生物芯片，提供了一种用于生物芯片的基板，该基板不会发生斑点扩散并且由于相邻斑点之间的接触而不会发生交叉污染。 还发现，即使每个凹槽的体积非常小（小至1nL至10nL），测试样品中目标分子的期望结合在溶液系统中以可检测的水平发生。

    NOVEL COMPOUND AND ANGIOGENIC AGENT COMPRISING SAME
    9.
    发明公开
    NOVEL COMPOUND AND ANGIOGENIC AGENT COMPRISING SAME 审中-公开

    公开(公告)号：EP3907235A1

    公开(公告)日：2021-11-10

    申请号：EP19891727.0

    申请日：2019-10-31

    申请人： HiPep Laboratories

    发明人： NOKIHARA, Kiyoshi ,  TOMINAGA, Yuki ,  KITAGAWA, Atsushi ,  NOKIHARA, Shun

    IPC分类号： C07K7/06 ,  A61K38/08 ,  A61K38/12

    摘要： Disclosed are a novel compound having a higher angiogenic effect than that of a known peptide-based angiogenic agent, and an angiogenic agent including the novel compound. The compound is represented by the following formula [I]: Cyclic(Cys-O2Oc-SVV(F/Y)GLRG-Cys)-NH 2 (wherein the number of oxyethylene units, represented by 020c, is within the range of 2 to 6), the following formula [II]: Cyclic(O 2 Oc-SVV(F/Y)GLRQ)-NH 2 [II] (wherein the number of oxyethylene units, represented by O2Oc, is within the range of 2 to 6), or the following formula [III]: O 2 Oc-SVV(F/Y)GLR-NH 2 [III] (wherein the number of oxyethylene units, represented by 020c, is within the range of 2 to 6).