公开(公告)号：EP2615101B1

公开(公告)日：2018-10-17

申请号：EP11823062.2

申请日：2011-09-02

申请人： High & New Technology Research Center, Henan Academy of Sciences ,  Zhengzhou Granlen Pharmatech Ltd. ,  Zhengzhou University

发明人： CHANG, Junbiao ,  AN, Haoyun ,  YU, Xuejun ,  GUO, Xiaohe

IPC分类号： C07H19/06 ,  C07H1/00 ,  A61K31/7068 ,  A61P35/00 ,  A61P35/02 ,  A61P31/12 ,  A61P31/20 ,  A61P31/14 ,  A61P31/18 ,  A61P31/22

CPC分类号： C07H19/06 ,  C07H19/14

摘要： The present invention relates to the field of pharmacochemistry. Disclosed are fluorinated and azido-substituted pyrimidine nucleoside derivatives, and preparation methods and uses thereof. The structural formula is as shown (I). These compounds can be used for preparing medicaments for treating diseases such as tumors and viral infections, and can be used separately or in combination with other medicaments. The compounds also have effective activity against diseases such as tumors and viral infections, while having few side effects, and thus have potential application value.

公开(公告)号：EP2615101A1

公开(公告)日：2013-07-17

申请号：EP11823062.2

申请日：2011-09-02

申请人： High & New Technology Research Center, Henan Academy of Sciences ,  Zhengzhou Granlen Pharmatech Ltd. ,  Zhengzhou University

发明人： CHANG, Junbiao ,  AN, Haoyun ,  YU, Xuejun ,  GUO, Xiaohe

IPC分类号： C07H19/06 ,  C07H1/00 ,  A61K31/7068 ,  A61P35/00 ,  A61P35/02 ,  A61P31/12 ,  A61P31/20 ,  A61P31/14 ,  A61P31/18 ,  A61P31/22

CPC分类号： C07H19/06 ,  C07H19/14

摘要： The present invention relates to the field of pharmacochemistry. Disclosed are fluorinated and azido-substituted pyrimidine nucleoside derivatives, and preparation methods and uses thereof. The structural formula is as shown (I). These compounds can be used for preparing medicaments for treating diseases such as tumors and viral infections, and can be used separately or in combination with other medicaments. The compounds also have effective activity against diseases such as tumors and viral infections, while having few side effects, and thus have potential application value.

公开(公告)号：EP2177527B1

公开(公告)日：2013-12-18

申请号：EP08772992.7

申请日：2008-06-27

申请人： Zhengzhou University ,  Henan Analysis Testing Center

发明人： CHANG, Junbiao

IPC分类号： C07H19/06 ,  C07H19/14 ,  C07H19/16 ,  A61K31/7064 ,  A61K31/7076 ,  A61P31/12 ,  A61P1/16

CPC分类号： C07H19/06 ,  C07H19/14 ,  C07H19/16

摘要： The present invention provides 2'-fluorine-4'-substituted-nucleoside analogues or their pro-drugs or 5'-phosphate esters (including the pro-drugs of the 5'-phosphate esters), preparation methods and uses thereof. The compounds have the general formula as follows: wherein: R = CH 3 , CH, N 3 , C‰¡CH; R' = H, F; X = F, OH, NH 2 ; Y = H, CH 3 , F, OH, NH 2 The compounds are used in the synthesis of drugs for the treatment of virus infection, especially for the treatment of HBV, HCV or HIV infection.

公开(公告)号：EP2177527A1

公开(公告)日：2010-04-21

申请号：EP08772992.7

申请日：2008-06-27

申请人： Zhengzhou University ,  Analyse Testing And Research Center Of Henan Province

发明人： CHANG, Junbiao

IPC分类号： C07H19/06 ,  C07H19/14 ,  C07H19/16 ,  A61K31/7064 ,  A61K31/7076 ,  A61P31/12 ,  A61P1/16

CPC分类号： C07H19/06 ,  C07H19/14 ,  C07H19/16

摘要： The present invention provides 2'-fluorine-4'-substituted-nucleoside analogues or their pro-drugs or 5'-phosphate esters (including the pro-drugs of the 5'-phosphate esters), preparation methods and uses thereof. The compounds have the general formula as follows:

wherein:

R = CH 3 , CH, N 3 , C≡CH;
R' = H, F;
X = F, OH, NH 2 ;
Y = H, CH 3 , F, OH, NH 2
The compounds are used in the synthesis of drugs for the treatment of virus infection, especially for the treatment of HBV, HCV or HIV infection.

摘要翻译： 本发明提供了2'-氟-4'-取代的核苷类似物或其前药或5'-磷酸酯（包括5'-磷酸酯的前药），其制备方法和用途。 该化合物具有如下通式：其中：R = CH 3，CH，N 3，C‰CH; R'= H，F; X = F，OH，NH 2; Y = H，CH 3，F，OH，NH 2化合物用于合成用于治疗病毒感染的药物，特别是用于治疗HBV，HCV或HIV感染。