公开(公告)号：EP3341390A2

公开(公告)日：2018-07-04

申请号：EP16760425.5

申请日：2016-08-25

申请人： Histide AG

发明人： ZOUANI, Omar F.

IPC分类号： C07K7/64 ,  C07K14/51 ,  A61K38/12 ,  A61K38/18

CPC分类号： C07K7/64 ,  A61K8/64 ,  A61K38/00 ,  A61Q7/00 ,  A61Q19/08 ,  C07K14/51 ,  Y02A50/409 ,  Y02A50/411

摘要： The present disclosure provides a cyclic peptide, or a variant or analog thereof, or a cyclic peptidomimetic, with between 10 and 35 amino acids, having a growth factor receptor-binding capability and comprising a peptide with four amino acids PEP1; wherein PEP1 is selected from the group consisting of SAIS, SSLS, NAIS, SATS, SPIS, EPIS, SPIN, KPLS, EPLP, EPLT, SNIT, RSVK and RPVQ.

公开(公告)号：EP3349777A2

公开(公告)日：2018-07-25

申请号：EP16770462.6

申请日：2016-09-15

申请人： Histide AG

发明人： ZOUANI, Omar F. ,  GOCHEVA, Veronika

IPC分类号： A61K38/05 ,  A61L27/12 ,  A61L27/34 ,  A61K38/07 ,  A61K38/08 ,  A61K38/10 ,  A61K38/12 ,  A61L27/54 ,  A61K38/18 ,  A61K9/16 ,  G06F19/16

CPC分类号： A61K38/18 ,  A61K38/05 ,  A61K38/07 ,  A61K38/08 ,  A61K38/10 ,  A61K38/12 ,  G06F19/16

摘要： The present disclosure provides a pharmaceutical association for use in the treatment, prevention and/or diagnostic of a neoplastic disease, said association comprising at least one growth factor receptor-binding compound, which activates at least one growth factor receptor of a neoplastic cell, and at least one bioactive carrier forming at least one covalent or non-covalent interaction with said at least one growth factor receptor-binding compound, and wherein said association reduces or suppresses, in the neoplastic cell, the gene expression of at least one cyclin D and/or reduces or suppresses the formation of at least one complex formed between said at least one cyclin D and at least one of cyclin dependent-kinase 4 or 6.

公开(公告)号：EP3349782A2

公开(公告)日：2018-07-25

申请号：EP16770237.2

申请日：2016-09-15

申请人： Histide AG

发明人： ZOUANI, Omar F. ,  GOCHEVA, Veronika

IPC分类号： A61K38/18 ,  A61L27/12 ,  A61L27/34 ,  A61K38/05 ,  A61K38/07 ,  A61K38/08 ,  A61K38/10 ,  A61K38/12 ,  A61L27/54 ,  A61K9/16 ,  G06F19/16 ,  A61P35/00

CPC分类号： A61K38/18 ,  A61K38/05 ,  A61K38/07 ,  A61K38/08 ,  A61K38/10 ,  A61K38/12 ,  A61K38/1875 ,  A61K47/50 ,  A61L27/12 ,  A61L27/22 ,  A61L27/24 ,  A61L27/34 ,  A61L27/40 ,  A61L27/54 ,  A61L2300/416 ,  A61L2400/06 ,  A61L2430/02

摘要： The present disclosure provides a pharmaceutical association for use in the treatment, prevention and/or diagnostic of a neoplastic disease, said association comprising at least one growth factor receptor-binding compound, which activates at least one growth factor receptor of a neoplastic cell, and at least one bioactive carrier forming at least one covalent or non-covalent interaction with said at least one growth factor receptor-binding compound, and wherein said association reduces or suppresses, in the neoplastic cell, the gene expression of at least one cyclin D and/or reduces or suppresses the formation of at least one complex formed between said at least one cyclin D and at least one of cyclin dependent-kinase 4 or 6.

公开(公告)号：EP3349778A2

公开(公告)日：2018-07-25

申请号：EP16770464.2

申请日：2016-09-15

申请人： Histide AG

发明人： ZOUANI, Omar F. ,  GOCHEVA, Veronika

IPC分类号： A61K38/05 ,  A61K38/07 ,  A61K38/08 ,  A61K38/10 ,  A61K38/12 ,  A61K38/16 ,  A61K39/395 ,  A61K45/06 ,  A61K31/70 ,  C07K16/28 ,  A61P35/00 ,  A61K38/18 ,  G06F19/16

CPC分类号： A61K38/18 ,  A61K31/713 ,  A61K38/05 ,  A61K38/07 ,  A61K38/08 ,  A61K38/10 ,  A61K38/12 ,  A61K39/39558 ,  A61K45/06 ,  C07K16/2839 ,  C07K16/2842 ,  A61K2300/00

摘要： The present disclosure provides a pharmaceutical association comprising at least one growth factor receptor-binding compound, which activates at least one growth factor receptor of a neoplastic cell, and at least one adhesion protein inhibitor which inhibits at least one transmembrane cell adhesion protein of said neoplastic cell.

公开(公告)号：EP3349776A2

公开(公告)日：2018-07-25

申请号：EP16766294.9

申请日：2016-09-15

申请人： Histide AG

发明人： ZOUANI, Omar F. ,  GOCHEVA, Veronika

IPC分类号： A61K38/05 ,  A61K38/07 ,  A61K38/08 ,  A61K38/10 ,  A61K38/12 ,  A61K38/16 ,  A61K39/395 ,  A61K45/06 ,  A61K31/70 ,  C07K16/28 ,  A61P35/00 ,  A61K38/18 ,  G06F19/16

CPC分类号： A61K38/18 ,  A61K31/7105 ,  A61K38/05 ,  A61K38/07 ,  A61K38/08 ,  A61K38/10 ,  A61K38/12 ,  A61K45/06 ,  C07K16/2839 ,  C07K2317/70 ,  C07K2317/76 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/531

摘要： A pharmaceutical association comprising at least one growth factor receptor-binding compound, which activates at least one growth factor receptor of a neoplastic cell, and at least one adhesion protein inhibitor which inhibits at least one transmembrane cell adhesion protein of said neoplastic cell.

公开(公告)号：EP3341399A2

公开(公告)日：2018-07-04

申请号：EP16762985.6

申请日：2016-08-25

申请人： Histide AG

发明人： ZOUANI, Omar F.

IPC分类号： C07K14/51 ,  A61K38/12 ,  A61K38/18 ,  C07K7/64

CPC分类号： C07K7/64 ,  A61K8/64 ,  A61K38/00 ,  A61P19/00 ,  A61Q7/00 ,  A61Q19/08 ,  C07K14/51 ,  Y02A50/409 ,  Y02A50/411

摘要： The present disclosure provides a cyclic peptide, or a variant or analog thereof, or a cyclic peptidomimetic, with between 15 and 35 amino acids, having a growth factor receptor-binding capability and comprising a peptide with four amino acids PEP1, and a peptide with five amino acids PEP2; wherein PEP1 is selected from the group consisting of SAIS, SSLS, NAIS, SATS, SPIS, EPIS, SPIN, KPLS, EPLP, EPLT, SNIT, RSVK and RPVQ; and wherein PEP2 is selected from the group consisting of LKNYQ, LKVYP, LKKYR, LRKHR, LKYHY, KFKYE, YGKIP, YKQYE, DHHKD, EQLSN, IGEMS, LGEMS, KEVQV and KKATV.

公开(公告)号：EP3341398A2

公开(公告)日：2018-07-04

申请号：EP16762749.6

申请日：2016-08-25

申请人： Histide AG

发明人： ZOUANI, Omar F.

IPC分类号： C07K14/51

CPC分类号： C07K14/51 ,  A61L27/227 ,  C07K2299/00

摘要： The present disclosure provides peptides, or variants or analogs thereof, with between 8 and 30 amino acids, having growth factor receptor-binding capability, wherein the RMSD value of the structure coordinates of said peptide, variant or analog thereof with respect to PEPREF is 2.45A (Angstroms) or less.

公开(公告)号：EP3341397A2

公开(公告)日：2018-07-04

申请号：EP16762748.8

申请日：2016-08-25

申请人： Histide AG

发明人： ZOUANI, Omar F.

IPC分类号： C07K14/51

CPC分类号： C07K14/51 ,  C07K2299/00

摘要： The present disclosure provides a peptide, or a variant or analog thereof, or peptidomimetic comprising between 25 and 60 amino acids, having growth factor receptor-binding capability, wherein the RMSD value of the structure coordinates of said peptide, variant or analog thereof with respect to PEPREF is 2.45Å (Angstroms) or less.