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    BARBITURIC ACID DERIVATIVE AND PREVENTIVE AND THERAPEUTIC AGENT FOR BONE AND CARTILAGE CONTAINING THE SAME
    1.
    发明公开
    BARBITURIC ACID DERIVATIVE AND PREVENTIVE AND THERAPEUTIC AGENT FOR BONE AND CARTILAGE CONTAINING THE SAME 审中-公开
    巴比土酸衍生物与该含，预防及治疗剂用于作用骨骼和软骨

    公开(公告)号：EP1064269A1

    公开(公告)日：2001-01-03

    申请号：EP99919495.4

    申请日：1999-03-23

    申请人： Hoechst Marion Roussel

    发明人： SAKAI, Kunikazu ,  SATOH, Yusuke

    IPC分类号： C07D239/62 ,  A61K31/515

    CPC分类号： C07D409/06 ,  C07D239/62

    摘要： The present invention relates to a barbituric acid derivative shown in formula (I) (wherein R or R1 independently represents a hydrogen atom, a susbstituted or not substituted alkyl group or alkenyl group of C¿1? - C15, a substituted or not substituted arylmethyl group, and substituted or not substituted aryl group, and R?2¿ represents substituted or not substituted alkyl group or alkenyl group of C¿1? - C15, a substituted or not substituted arylmethyl group, and substituted or not substituted aryl group). The barbituric acid derivative of the present invention has a strong inhibiting activity to bone resorption and is useful as a preventive and therapeutic agent for diseases affecting bone and cartilage.

    NOVEL PROTEIN AND PROCESS FOR PRODUCING THE SAME
    2.
    发明公开
    NOVEL PROTEIN AND PROCESS FOR PRODUCING THE SAME 无效
    在维他命ZU DESSEN HERSTELLUNG附近的蛋白质

    公开(公告)号：EP0955313A1

    公开(公告)日：1999-11-10

    申请号：EP96910198.9

    申请日：1996-04-19

    申请人： Hoechst Marion Roussel, Ltd.

    发明人： MAKISHIMA, Fusao ,  TAKAMATSU, Hiroyuki ,  MIKI, Hideo ,  KAWAI, Shinji ,  KIMURA, Michio ,  MATSUMOTO, Tomoaki ,  KATSUURA, Mieko ,  ENOMOTO, Koichi ,  SATOH, Yusuke

    IPC分类号： C07K14/51 ,  C12N15/12 ,  A61K38/17 ,  C12P21/02

    CPC分类号： C07K14/51 ,  A61K38/00 ,  Y10S514/801

    摘要： A protein having amino acid sequence in SEQ ID No.:1 of the Sequence Listing derived from human MP52, and a dimer protein thereof. A homodimer protein described above can be obtained by constructing a plasmid containing DNA coding amino acid sequence in SEQ ID No.:1 of the Sequence Listing with a methionine at the N-terminus, introducing the plasmid into E . coli for transformation, solubilizing inclusion bodies obtained by culturing the transformant, purifying the monomer protein from the solubilized solution, refolding the monomer protein into a dimer protein and purifying the same.
    The homodimer protein described above is useful as a pharmaceutical composition for treating cartilage and bone diseases.

    摘要翻译： 衍生自人MP52的序列表的SEQ ID No.1中具有氨基酸序列的蛋白质及其二聚体蛋白质。 可以通过在N末端构建含有序列表SEQ ID No.1的DNA编码氨基酸序列的质粒与甲硫氨酸，将质粒导入大肠杆菌进行转化，溶解包合物来获得上述同型二聚体蛋白 通过培养转化体获得的物质，从​​溶解的溶液中纯化单体蛋白质，将单体蛋白质重新折叠成二聚体蛋白质并将其纯化。 上述同型二聚体蛋白质可用作治疗软骨和骨疾病的药物组合物。