公开(公告)号：EP3508216A1

公开(公告)日：2019-07-10

申请号：EP17846744.5

申请日：2017-09-04

申请人： Hokusan Co. Ltd. ,  National Institute of Advanced Industrial Science and Technology ,  School Juridical Person The Kitasato Institute

发明人： TABAYASHI, Noriko ,  GOTANDA, Toru ,  SASAKI, Hanae ,  ITCHODA, Noriko ,  KAGAYA, Uiko ,  MATSUMURA, Takeshi ,  ITO, Akira ,  IKADAI, Hiromi

IPC分类号： A61K39/015 ,  C07K14/445 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09

摘要： It is an object of the present invention to provide a transmission-blocking vaccine using an immunogenic protein which is specifically expressed in the oocyst stage of malaria parasites or a peptide fragment thereof, and an oral transmission-blocking vaccine capable of immunizing various animals involved in the malaria infectious cycle with such a vaccine.
The present invention relates to a malaria transmission-blocking vaccine for oral administration containing an immunogenic protein derived from malaria parasite which is specifically expressed in the oocyst stage of malaria parasites or a peptide fragment thereof, and a method of blocking the transmission of malaria using the same.

公开(公告)号：EP3278812A1

公开(公告)日：2018-02-07

申请号：EP16771815.4

申请日：2016-01-12

申请人： National Institute of Advanced Industrial Science and Technology ,  Hokusan Co. Ltd.

发明人： ITO, Akira ,  MATSUMURA, Takeshi ,  GOTANDA, Toru ,  TABAYASHI, Noriko ,  ITCHODA, Noriko ,  AOKI, Takashi ,  KAGAYA, Uiko

IPC分类号： A61K38/21 ,  A61K9/20 ,  A61K9/68 ,  A61P27/16 ,  A61P29/00

CPC分类号： A61K9/20 ,  A23L33/00 ,  A61K38/212 ,  A61P27/16

摘要： The object of the present invention is to provide a therapeutic agent illustrating an immediate and sustained effect on chronic intractable external otitis. The present invention provide a composition, pharmaceutical composition, food and feed for preventing and/or treating chronic intractable external otitis, each comprising interferon-α (IFNα) as an active ingredient. Orally administering the composition of the present invention can provide inhibition, alleviation, treatment and prevention for chronic intractable external otitis. According to the present invention, IFNα can give a sufficient effect even when administered in a very small amount.

摘要翻译： 本发明的目的是提供说明对慢性顽固性外耳炎立即和持续作用的治疗剂。 本发明提供了用于预防和/或治疗慢性顽固性外耳炎的组合物，药物组合物，食品和饲料，各自包含干扰素-α（IFNα）作为活性成分。 口服本发明的组合物可以为慢性顽固性外耳炎提供抑制，减轻，治疗和预防。 根据本发明，即使以非常少的量给药，IFNα也能够产生充分的效果。

公开(公告)号：EP3075392A1

公开(公告)日：2016-10-05

申请号：EP14865227.4

申请日：2014-11-25

申请人： Idemitsu Kosan Co., Ltd. ,  National Institute of Advanced Industrial Science and Technology ,  Hokusan Co. Ltd.

发明人： SAWADA, Kazutoshi ,  MATSUI, Takeshi ,  TAKITA, Eiji ,  MATSUMURA, Takeshi ,  ITO, Akira ,  TABAYASHI, Noriko

IPC分类号： A61K39/112 ,  A23K10/10 ,  A23K10/40 ,  A23K50/50 ,  A61K38/00 ,  A61P1/12 ,  A61P31/04 ,  C12N15/09

CPC分类号： A61K48/005 ,  A23K20/00 ,  A23K50/30 ,  A61K38/00 ,  A61K39/0258 ,  A61K2039/552 ,  C07K14/245 ,  C07K14/25 ,  Y02A50/474

摘要： The present invention provides an agent for controlling Escherichia coli diarrhea comprising a Shiga toxin as an active ingredient.

摘要翻译： 本发明提供一种用于控制大肠杆菌腹泻的药剂，其包含志贺毒素作为活性成分。

公开(公告)号：EP2098111A1

公开(公告)日：2009-09-09

申请号：EP07860044.2

申请日：2007-12-25

申请人： KAJIMA CORPORATION ,  National Institute of Advanced Industrial Science and Technology

发明人： YASUNO, Rie ,  ITO, Akira ,  TANAKA, Teruyoshi ,  MATSUMURA, Takeshi ,  SOMA, Ichiro ,  FUJITA, Hisaya ,  TAKASUNA, Hiroyuki

IPC分类号： A01G7/00 ,  A01G9/24 ,  E04H5/00

CPC分类号： A01G9/24 ,  A01G22/00 ,  E04H5/08 ,  Y02A40/264

摘要： This invention provides a transgenic plant factory (1) comprising a closed cultivation area (2) being kept at negative pressure and equipped with hydroponic system (4) for cultivating transgenic plants (P) and air-conditioner (5) with exhaust air-filter, an inactivation area (20) located next to said cultivation area (2) via air-locked passage (22) and being kept at negative pressure less strong than that at the cultivation area (2) and equipped with inactivation system (21) to prevent post-harvest transgenic plants (P) from sprouting, growing, proliferating or hybridizing, a manufacturing area (30) located next to said inactivation area (20) via air-locked passage (38) and being kept at positive pressure and being equipped with system (42, 43) for processing and/or preparing the post-harvest plants (P) into foodstuffs and/or pharmaceuticals, a sterilizer (60) for sterilizing the drainage from cultivation area (2), and air-locked workers' gateways (10, 14, 39, 35) provided to the cultivation area (2) and the manufacturing area (30) respectively.

摘要翻译： 本发明提供了一种转基因植物植物（1），其包括封闭的培养区域（2），其保持在负压下并且装备有用于培养转基因植物（P）的水培系统（4）和具有排气空气过滤器 ，经由空气锁定通道（22）位于所述培养区域（2）旁边的灭活区域（20），并且保持在比培养区域（2）处的强度低的负压并且配备有灭活系统（21）至 防止收获后转基因植物（P）发芽，生长，增殖或杂交，经由气锁通道（38）位于所述灭活区域（20）旁边的制造区域（30）并保持在正压力并且被装备 用于将收获后植物（P）加工和/或制备成食品和/或药物的系统（42,43），用于从栽培区域（2）消毒排水的消毒器（60） 网关（10，14，39，35）提供给栽培 （2）和制造区域（30）。