公开(公告)号：EP1530634A2

公开(公告)日：2005-05-18

申请号：EP03761989.7

申请日：2003-06-25

申请人： Human Genome Sciences, Inc.

发明人： LAIRD, Michael, W.

IPC分类号： C12N15/11 ,  C12N1/21 ,  C12N15/00 ,  C07H21/04

CPC分类号： C12N15/70 ,  C12N15/63

摘要： Novel Shine-Dalgarno (ribosome binding site) sequences, vectors containing such sequences, and host cells transformed with these vectors are provided. Methods of use of such sequences, vectors, and host cells for the efficient production of proteins and fragments thereof in prokaryotic systems are also provided. In particular embodiments of the invention, compounds and methods for high efficiency production of soluble protein in prokaryotic systems are provided.

公开(公告)号：EP2211888A1

公开(公告)日：2010-08-04

申请号：EP08843705.8

申请日：2008-10-30

申请人： HUMAN GENOME SCIENCES, INC.

发明人： ROSEN, Craig, A. ,  BELL, Adam ,  MOORE, Paul, A. ,  SHI, Yanggu ,  LAFLEUR, David ,  BOCK, Jason, B. ,  LAIRD, Michael, W. ,  HASELTINE, William, A. ,  WOODS, Douglas, B. ,  SUBRAMANIAN, Mani

IPC分类号： A61K38/00 ,  C07K17/00

CPC分类号： C07K14/58 ,  C07K14/765 ,  C07K2319/01

摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

公开(公告)号：EP1507793A2

公开(公告)日：2005-02-23

申请号：EP02786413.1

申请日：2002-10-16

申请人： Human Genome Sciences, Inc.

发明人： YU, Guo-Liang ,  EBNER, Reinhard ,  NI, Jian ,  ROSEN, Craig, A. ,  LAIRD, Michael, W. ,  ULLRICH, Stephen

IPC分类号： C07K2/00 ,  C07K14/00 ,  C07K14/52 ,  A61K38/16

CPC分类号： A61K51/08 ,  A61K38/00 ,  C07K14/525

摘要： The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.

摘要翻译： 本发明涉及编码嗜中性因子-α和/或中性因子-αSV多肽的核酸分子，包括可溶形式的胞外域。 还提供了中性因子-α和/或中性因子-αSV多肽以及载体，宿主细胞和用于产生它们的重组方法。 本发明还涉及特异性结合中性因子-α和/或中性因子-αSV的抗体或其部分以及使用这些抗体的诊断和治疗方法。 还提供了用于检测免疫系统相关病症的诊断方法和使用本发明组合物治疗免疫系统相关病症的治疗方法。