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1.发明授权
公开(公告)号：EP2376461B1
公开(公告)日：2015-03-11
申请号：EP10702454.9
申请日：2010-01-15
发明人： VIOLA, Antonella , BRONTE, Enzo , CROSETTI, Marco , LAZZARATO, Loretta , FRUTTERO, Roberta , GASCO, Alberto
IPC分类号： A61K31/4245
CPC分类号： C07D271/10 , C07D498/04
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2.发明公开
公开(公告)号：EP2376461A1
公开(公告)日：2011-10-19
申请号：EP10702454.9
申请日：2010-01-15
发明人： VIOLA, Antonella , BRONTE, Enzo , CROSETTI, Marco , LAZZARATO, Loretta , FRUTTERO, Roberta , GASCO, Alberto
IPC分类号： C07D271/10 , C07D498/04 , A61P35/04 , A61P35/00 , A61K31/4245
CPC分类号： C07D271/10 , C07D498/04
摘要： The present invention relates to nitric oxide furoxan derivative compounds which showed to be active in the treatment of tumors. In addition, they may be used as adjuvants in cancer immunotherapy.
摘要翻译： 本发明涉及显示在肿瘤治疗中有活性的一氧化氮呋肟衍生物化合物。 另外，它们可以用作癌症免疫疗法的佐剂。
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公开(公告)号：EP2539328B1
公开(公告)日：2014-07-30
申请号：EP11711666.5
申请日：2011-02-23
发明人： VIOLA, Antonella , BRONTE, Enzo , CROSETTI, Marco , LAZZARATO, Loretta , FRUTTERO, Roberta , GASCO, Alberto
IPC分类号： C07D271/08 , A61K31/4245 , A61P35/00 , A61P29/00
CPC分类号： C07D271/08 , A61K31/4245
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4.发明公开
公开(公告)号：EP2539328A1
公开(公告)日：2013-01-02
申请号：EP11711666.5
申请日：2011-02-23
发明人： VIOLA, Antonella , BRONTE, Enzo , CROSETTI, Marco , LAZZARATO, Loretta , FRUTTERO, Roberta , GASCO, Alberto
IPC分类号： C07D271/08 , A61K31/4245 , A61P35/00 , A61P29/00
CPC分类号： C07D271/08 , A61K31/4245
摘要： The present invention finds application in the field of medicine and, in particular, it regards novel water soluble compounds with furoxan structure capable of inhibiting metabolic pathways involved in the development of the tumours. The use of the compounds of the invention as a medicament in the therapy of the tumours and as an adjuvant in the immunotherapy protocols against neoplasms is also described.
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