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公开(公告)号：EP3192805A1
公开(公告)日：2017-07-19
申请号：EP16151539.0
申请日：2016-01-15
IPC分类号： C07K14/705 , A61K38/17 , C07K16/46
CPC分类号： C07K14/705 , A61K38/1709 , A61K38/1774 , A61K39/395 , C07K2319/30
摘要： The present invention refers to an inhibitor of T cell costimulation and/or activation and/or function for use in the treatment and/or prevention of cardiac pathologies, preferably heart failure diseases, and/or of related symptoms.
摘要翻译： 本发明涉及用于治疗和/或预防心脏病，优选心力衰竭疾病和/或相关症状的T细胞共刺激和/或活化和/或功能抑制剂。
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2.发明授权
公开(公告)号：EP2376461B1
公开(公告)日：2015-03-11
申请号：EP10702454.9
申请日：2010-01-15
发明人： VIOLA, Antonella , BRONTE, Enzo , CROSETTI, Marco , LAZZARATO, Loretta , FRUTTERO, Roberta , GASCO, Alberto
IPC分类号： A61K31/4245
CPC分类号： C07D271/10 , C07D498/04
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3.发明公开
公开(公告)号：EP2376461A1
公开(公告)日：2011-10-19
申请号：EP10702454.9
申请日：2010-01-15
发明人： VIOLA, Antonella , BRONTE, Enzo , CROSETTI, Marco , LAZZARATO, Loretta , FRUTTERO, Roberta , GASCO, Alberto
IPC分类号： C07D271/10 , C07D498/04 , A61P35/04 , A61P35/00 , A61K31/4245
CPC分类号： C07D271/10 , C07D498/04
摘要： The present invention relates to nitric oxide furoxan derivative compounds which showed to be active in the treatment of tumors. In addition, they may be used as adjuvants in cancer immunotherapy.
摘要翻译： 本发明涉及显示在肿瘤治疗中有活性的一氧化氮呋肟衍生物化合物。 另外，它们可以用作癌症免疫疗法的佐剂。
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公开(公告)号：EP2182931A2
公开(公告)日：2010-05-12
申请号：EP08786280.1
申请日：2008-07-21
申请人： Humanitas Mirasole S.p.A. , Politecnico di Milano , Istituto di Ricerche Chimiche e Biochimiche Giuliana Ronzoni
发明人： GRAZIANI, Giorgio , MONTANELLI, Alessandro , MELONE, Lucio , VISMARA, Elena , TORRI, Giangiacomo
CPC分类号： A61K9/7007 , C08B11/12 , C08B11/187 , C08B37/0012 , Y02A50/473
摘要： The present invention regards a polysaccharide or hydrocarbon-carrying material functionalised with a monomer chosen from among glycidyl methacrylate, acrylic acid, N-vinylpyrrolidone, acrylamide and vinyl acetate, impregnated with at least one pharmaceutical active principle. The active principle is preferably an antibiotic drug.
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5.发明授权DIAGNOSTIC TEST FOR INFLAMMATORY ENDOTHELIAL DYSFUNCTIONS IN PREGNANCIES 有权诊断测试炎症ENDOTHELFEHLFUNKTIONEN在怀孕
公开(公告)号：EP1966612B1
公开(公告)日：2010-03-24
申请号：EP06829691.2
申请日：2006-12-18
IPC分类号： G01N33/68
CPC分类号： G01N33/689 , C07K16/24 , G01N33/543 , G01N2333/4715 , G01N2800/368 , G01N2800/50 , G01N2800/7095
摘要： The present invention relates to a diagnostic test for inflammatory endothelial dysfunctions in pregnant women. Particularly, the present invention relates to a method of diagnosing or evaluating the risk of contracting an inflammatory endothelial dysfunction of the maternal compartment comprising the following steps: a) detecting the plasma levels of long pentraxin PTX3 in blood samples taken from a pregnant woman; b) comparing the PTX3 plasma level data, obtained according to step a) , with statistically significant PTX3 plasma level data of normal pregnant population.
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6.发明公开DIAGNOSTIC TEST FOR INFLAMMATORY ENDOTHELIAL DYSFUNCTIONS IN PREGNANCIES 有权诊断测试炎症ENDOTHELFEHLFUNKTIONEN在怀孕
公开(公告)号：EP1966612A1
公开(公告)日：2008-09-10
申请号：EP06829691.2
申请日：2006-12-18
IPC分类号： G01N33/68
CPC分类号： G01N33/689 , C07K16/24 , G01N33/543 , G01N2333/4715 , G01N2800/368 , G01N2800/50 , G01N2800/7095
摘要： The present invention relates to a diagnostic test for inflammatory endothelial dysfunctions in pregnant women. Particularly, the present invention relates to a method of diagnosing or evaluating the risk of contracting an inflammatory endothelial dysfunction of the maternal compartment comprising the following steps: a) detecting the plasma levels of long pentraxin PTX3 in blood samples taken from a pregnant woman; b) comparing the PTX3 plasma level data, obtained according to step a) , with statistically significant PTX3 plasma level data of normal pregnant population.
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7.发明公开METHOD AND APPARATUS FOR ANALYZING BIOLOGICAL TISSUES 审中-公开VERFAHREN UND VORRICHTUNG ZUM ANALYSIEREN BIOLOGISCHER GEWEBE
公开(公告)号：EP1642234A1
公开(公告)日：2006-04-05
申请号：EP03817415.7
申请日：2003-07-09
申请人： Humanitas Mirasole S.p.A. , Fondazione "Michele Rodriguez" - Istituto Scientifico per le Misure Quantitative in Medicina
发明人： DIOGUARDI, Nicola , GRIZZI, Fabio , RUSSO, Carlo , FRANCESCHINI, Barbara , VINCIGUERRA, Paolo , TORRES-MUNOZ, Ingrid
CPC分类号： G06T7/0012 , G06T7/55 , G06T7/62 , G06T2207/30024
摘要： The present invention relates to a method and an apparatus for processing images of irregularly shaped objects, such as biological specimens, in particular of human or animal origin, or images thereof. The metric quantification of a biological body part or tissue or of a material spot or aggregate of any origin, which is contained therein, is also performed by means of the invention method. In particular, the method of the present invention is applied to the 'confocal microscopy' technique. In particular, the present invention relates to a method of processing digital images comprising one or more objects to be quantified, the said method comprising the following main stages:- normalization of the digital images; - quantization of the images to one bit, further comprising at least one of the following stages: - calculating, from the said images quantized to one bit, the perimeter, area and/or fractal dimension of the said one or more objects to be quantified; - reconstructing, from the said images quantized to one bit, a 3D-image of the said one or more objects to be quantified, and/or- calculating, from the said normalized images, the fractal dimension of the overall image.
摘要翻译： 本发明涉及一种用于处理不规则形状的物体，特别是人或动物来源的生物标本的图像的方法和装置，或其图像。 生物体部位或组织或包含在其中的任何来源的物质斑点或聚集体的度量定量也通过本发明的方法进行。 特别地，本发明的方法应用于“共焦显微镜”技术。 具体而言，本发明涉及一种处理数字图像的方法，该数字图像包括要量化的一个或多个对象，该方法包括数字图像的归一化和图像的量化到一位。 该方法还包括至少从量化到一位的图像中计算要量化和/或重建的一个或多个对象的周边，面积和/或分形维数，从量化到一位的图像，3D- 要被量化的一个或多个对象的图像，和/或从归一化图像计算整个图像的分形维数。
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公开(公告)号：EP1576085A1
公开(公告)日：2005-09-21
申请号：EP02808318.6
申请日：2002-12-24
发明人： PARMEGGIANI, Luciano, Istituto Clinico Humanitas , DIOGUARDI, Nicola, Istituto Clinico Humanitas , GRIZZI, Fabio, Istituto Clinico Humanitas
CPC分类号： C12M23/08 , C12M29/00 , C12M29/26 , C12M33/02 , C12M41/00 , C12M41/46 , C12M41/48 , G01N1/2813
摘要： The present invention relates to an analytical device (1) for cell cultures comprising a container (4) for cell cultures, a reservoir (2) for the storage of fresh culture medium for said cell cultures, pumping means (3) suitable to introduce said fresh culture medium into said container and to remove metabolised culture medium from the cell cultures of said of said container and a depositing device (5) suitable for depositing the metabolised culture medium removed from said container by means of said pumping means onto an analytical support (11).
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公开(公告)号：EP4003415A1
公开(公告)日：2022-06-01
申请号：EP20743142.0
申请日：2020-07-22
IPC分类号： A61K39/395 , A61K38/17 , A61P35/00 , G01N33/50
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