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    A method for carrying out the synthesis of a contraceptive and menstrual cycle controlling drug having oncostatic, antikinetosic, preventive and therapeutic properties for treatment of mammary tumours and melanomas.
    3.
    发明公开
    A method for carrying out the synthesis of a contraceptive and menstrual cycle controlling drug having oncostatic, antikinetosic, preventive and therapeutic properties for treatment of mammary tumours and melanomas. 失效
    Kontrazeptives und menstruzeszyklusregulierendesPräparatmit onkostatischen Eigenschaften。

    公开(公告)号：EP0483077A2

    公开(公告)日：1992-04-29

    申请号：EP91830402.3

    申请日：1991-09-27

    申请人： I.F.L.O. S.a.s. di Giorgio e Aldo Laguzzi

    发明人： Fraschini, Franco, I.F.L.O. S.a.s. ,  Duranti, Ermanno, I.F.L.O. S.a.s. ,  Di Bella, Luigi, I.F.L.O. S.a.s. ,  Stankov, Bojidar, I.F.L.O. S.a.s. ,  Laguzzi, Aldo, I.F.L.O. S.a.s.

    IPC分类号： A61K31/565 ,  A61K31/57 ,  C07D209/30 ,  C07D457/02

    CPC分类号： A61K31/40 ,  A61K31/565 ,  A61K31/57 ,  Y10S514/843 ,  A61K31/405 ,  A61K2300/00

    摘要： The present invention relates to a drug for human use, having contraceptive and menstrual cycle controlling properties, characterized in that the said drug comprises N-acetyl-5-methoxytryptamine or melatonin, in a dose of 100-200 mg pro die, N-acetyl-2-bromo-5-methoxytryptamine or 2-bromomelatonin in a dose of 25-50 mg pro die N-acetyl-2-iodo-5-methoxytryptamine or 2-iodomelatonin, in a dose of 20-40 mg pro die, in association with a progestinic compound.
    The administration is carried out for 23 days, by using an association of 2-iodomelatonin and/or melatonin and/or 2-bromomelatonin and a progestinic compound, followed by 5 days in which only 2-iodomelatonin and/or melatonin and/or 2-bromomelatonin is administered; the drug having oncostatic preventive and therapeutic properties, in mammary tumours and melanomas, characterized by the use of 2-iodomelatonin, melatonin and 2-bromomelatonin respectively with doses of 20-40 mg, 100-200 mg, 25-50 mg pro die; and the said drug having moreover antikinetosic properties, and being characterized by the use of 2-iodomelatonin in a dose pro die of 2.5 mg, melatonin, in a dose pro die of 10 mg and 2-bromomelatonin in a dose pro die of 3.5 mg, either individually and/or in association with the acetyl coenzime A-(AcCoA), in a dose of 8-10 mg pro die.

    摘要翻译： 本发明涉及一种具有避孕和月经周期控制性质的人类用药，其特征在于所述药物包含N-乙酰基-5-甲氧基色胺或褪黑素，剂量为100-200mg，N-乙酰基 -2-溴-5-甲氧基色胺或2-溴代褪黑激素，剂量为25-50mg，以20-40mg原料的剂量，N-乙酰基-2-碘-5-甲氧基色胺或2-碘代褪黑素 与孕激素联合。 通过使用2-碘褪黑激素和/或褪黑激素和/或2-溴褪黑素和孕激素化合物的联合进行23天，随后5天，其中只有2-碘褪黑激素和/或褪黑激素和/或2 -bromomelatonin被施用; 该药物具有乳腺肿瘤和黑色素瘤的预防和治疗性质，其特征在于分别以20-40mg，100-200mg，25-50mg剂量的2-碘褪黑激素，褪黑素和2-溴代褪黑激素使用; 并且所述药物具有进一步的抗丝氨酸特性，其特征在于使用剂量为2.5mg，褪黑激素的剂量为10mg的2-碘褪黑激素和剂量为2.5mg的2-溴代褪黑激素 单独和/或与乙酰辅酶A-（AcCoA）相关联，剂量为8-10mg。