公开(公告)号：EP1721618A2

公开(公告)日：2006-11-15

申请号：EP06013179.4

申请日：2001-02-15

申请人： ID Biomedical Corporation of Quebec

发明人： Burt, David S. ,  Lowell, George H. ,  White, Gregory Lee ,  Fries, Louis F., III ,  Jones, David Hugh ,  Torossian, Kirkor ,  Plante, Martin

IPC分类号： A61K39/39 ,  A61K39/145 ,  A61K39/12 ,  A61K39/295 ,  A61P31/12 ,  A61P31/16

CPC分类号： A61K39/39 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5252 ,  A61K2039/543 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/70 ,  C12N2760/16134 ,  C12N2760/16234

摘要： Improved forms of vaccines which comprise proteosomes and protein antigens are described. Vaccines which contain influenza IIA as the antigen are used for illustration as to demonstrate efficacy. Improvements in the preparation of the vaccines themselves and the proteosome component are also included

摘要翻译： 描述了包含蛋白质体和蛋白质抗原的改进形式的疫苗。 含有IIA型流感疫苗作为抗原的疫苗用于说明效力。 还包括疫苗本身和蛋白质组分的制备的改进

公开(公告)号：EP1419784A3

公开(公告)日：2004-08-25

申请号：EP04000953.2

申请日：2001-02-15

申请人： ID Biomedical Corporation of Quebec

发明人： Burt, David S. ,  White, Gregory Lee ,  Lowell, George H ,  Fries, Louis F., III ,  Torossian, Kirkor ,  Jones, David Hugh ,  Plante, Martin

IPC分类号： A61K39/39 ,  A61P35/00 ,  A61P37/00 ,  A61P39/00

CPC分类号： A61K39/39 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5252 ,  A61K2039/543 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/70 ,  C12N2760/16134 ,  C12N2760/16234

摘要： There is disclosed a method to prepare a vaccine effective against allergy which method comprises: providing a mixture of at least one allergy protein antigen with a proteosome preparation in the presence of detergent; removing detergent from said mixture by diafiltration or ultrafiltration to obtain a proteosome-antigen composition; and formulating said composition into a vaccine. The invention is particularly concerned with preparing a vaccine effective against cancer or a biologic threat agent. The invention also provides a vaccine or composition prepared by the method of the invention and for the use of such composition in the preparation of a medicament for preventing or treating infection, allergy, cancer or biologic threat agent in an animal.

公开(公告)号：EP1721618A3

公开(公告)日：2007-01-10

申请号：EP06013179.4

申请日：2001-02-15

申请人： ID Biomedical Corporation of Quebec

发明人： Burt, David S. ,  Lowell, George H. ,  White, Gregory Lee ,  Fries, Louis F., III ,  Jones, David Hugh ,  Torossian, Kirkor ,  Plante, Martin

IPC分类号： A61K39/39 ,  A61K39/145 ,  A61K39/12 ,  A61K39/295 ,  A61P31/12 ,  A61P31/16

CPC分类号： A61K39/39 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5252 ,  A61K2039/543 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/70 ,  C12N2760/16134 ,  C12N2760/16234

摘要： Improved forms of vaccines which comprise proteosomes and protein antigens are described. Vaccines which contain influenza IIA as the antigen are used for illustration as to demonstrate efficacy. Improvements in the preparation of the vaccines themselves and the proteosome component are also included

公开(公告)号：EP1419784A2

公开(公告)日：2004-05-19

申请号：EP04000953.2

申请日：2001-02-15

申请人： ID Biomedical Corporation of Quebec

发明人： Burt, David S. ,  White, Gregory Lee ,  Lowell, George H ,  Fries, Louis F., III ,  Torossian, Kirkor ,  Jones, David Hugh ,  Plante, Martin

IPC分类号： A61K39/39 ,  A61P35/00 ,  A61P37/00 ,  A61P39/00

CPC分类号： A61K39/39 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5252 ,  A61K2039/543 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/70 ,  C12N2760/16134 ,  C12N2760/16234

摘要： There is disclosed a method to prepare a vaccine effective against allergy which method comprises: providing a mixture of at least one allergy protein antigen with a proteosome preparation in the presence of detergent; removing detergent from said mixture by diafiltration or ultrafiltration to obtain a proteosome-antigen composition; and formulating said composition into a vaccine. The invention is particularly concerned with preparing a vaccine effective against cancer or a biologic threat agent. The invention also provides a vaccine or composition prepared by the method of the invention and for the use of such composition in the preparation of a medicament for preventing or treating infection, allergy, cancer or biologic threat agent in an animal.

摘要翻译： 公开了一种制备抗过敏的疫苗的方法，该方法包括：在洗涤剂存在下提供至少一种过敏蛋白质抗原与蛋白体制剂的混合物; 通过渗滤或超滤从所述混合物中除去洗涤剂以获得蛋白体 - 抗原组合物; 并将所述组合物配制成疫苗。 本发明特别涉及制备有效抵抗癌症或生物威胁剂的疫苗。 本发明还提供了通过本发明的方法制备的疫苗或组合物以及用于制备用于预防或治疗动物体内的感染，变态反应，癌症或生物威胁剂的药物的用途。