公开(公告)号：EP1141298B1

公开(公告)日：2006-07-05

申请号：EP99966182.0

申请日：1999-12-14

申请人： IMMUNEX CORPORATION

发明人： SIMS, John, E. ,  SMITH, Dirk, E. ,  BORN, Teresa, L.

IPC分类号： C12N15/25 ,  C12N15/12 ,  C07K14/545 ,  C07K14/705 ,  C07K16/24 ,  C12N5/10 ,  C12Q1/68

CPC分类号： C07K14/545 ,  C07K14/7155 ,  C07K2319/00

摘要： The invention is directed to novel, purified and isolated IL-1 zeta, IL-1 zeta splice variants, and Xrec2 polypeptides and fragments thereof, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and uses thereof.

公开(公告)号：EP1450837A2

公开(公告)日：2004-09-01

申请号：EP02759279.9

申请日：2002-08-07

申请人： IMMUNEX CORPORATION

发明人： SIMS, John, E. ,  SMITH, Dirk, E.

IPC分类号： A61K38/00

CPC分类号： A61K38/1793 ,  A61K38/20 ,  A61K45/06 ,  A61K2300/00

摘要： The invention pertains to methods for treating medical disorders characterized by elevated levels or abnormal expression of IL-1 by administering an IL-1 antagonist, such as soluble type II IL-1 receptor and/or IL-1RacP.

公开(公告)号：EP1105485B1

公开(公告)日：2006-07-05

申请号：EP99945085.1

申请日：1999-08-20

申请人： IMMUNEX CORPORATION

发明人： SIMS, John, E. ,  SMITH, Dirk, E.

IPC分类号： C12N15/25 ,  C07K14/545 ,  C07K16/24 ,  A61K38/20 ,  A61P29/00 ,  A61P37/04

CPC分类号： C07K14/545 ,  A61K38/00

摘要： The invention is directed to purified and isolated novel human IL-1 epsilon polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, the use of such polypeptides and fragmented peptides in cellular and immune reactions and as molecular weight markers, the use of such polypeptides and fragmented peptides as controls for peptide fragmentation, and kits comprising these reagents.

公开(公告)号：EP1141298A2

公开(公告)日：2001-10-10

申请号：EP99966182.0

申请日：1999-12-14

申请人： IMMUNEX CORPORATION

发明人： SIMS, John, E. ,  SMITH, Dirk, E. ,  BORN, Teresa, L.

IPC分类号： C12N15/25 ,  C12N15/12 ,  C07K14/545 ,  C07K14/705 ,  C07K16/24 ,  C12N5/10 ,  C12Q1/68

CPC分类号： C07K14/545 ,  C07K14/7155 ,  C07K2319/00

摘要： The invention is directed to novel, purified and isolated IL-1 zeta, IL-1 zeta splice variants, and Xrec2 polypeptides and fragments thereof, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and uses thereof.

公开(公告)号：EP1105485A1

公开(公告)日：2001-06-13

申请号：EP99945085.1

申请日：1999-08-20

申请人： IMMUNEX CORPORATION

发明人： SIMS, John, E. ,  SMITH, Dirk, E.

IPC分类号： C12N15/25 ,  C07K14/545 ,  C07K16/24 ,  A61K38/20 ,  A61P29/00 ,  A61P37/04

CPC分类号： C07K14/545 ,  A61K38/00

摘要： The invention is directed to purified and isolated novel human IL-1 epsilon polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, the use of such polypeptides and fragmented peptides in cellular and immune reactions and as molecular weight markers, the use of such polypeptides and fragmented peptides as controls for peptide fragmentation, and kits comprising these reagents.

摘要翻译： 本发明涉及纯化和分离的新型人IL-1ε多肽，编码此类多肽的核酸，生产这些多肽的重组形式的方法，针对这些多肽产生的抗体，衍生自这些多肽的片段化肽，这些 细胞和免疫反应中的多肽和片段化肽以及作为分子量标记物，这些多肽和片段化肽作为肽片段化对照的用途，以及包含这些试剂的试剂盒。