公开(公告)号：EP1534840A4

公开(公告)日：2006-01-18

申请号：EP03766006

申请日：2003-07-23

申请人： IMMUSOL INC

发明人： LI HENRY ,  CHATTERTON JON E ,  KE NING ,  WONG-STAAL FLOSSIE

IPC分类号： C12N15/09 ,  C12N15/10 ,  C12N15/11 ,  C12N15/74 ,  C12Q1/68

CPC分类号： C12N15/111 ,  C12N15/1075 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2330/31

公开(公告)号：EP1677739A4

公开(公告)日：2008-07-23

申请号：EP04816110

申请日：2004-08-24

申请人： IMMUSOL INC

发明人： HU XIUYUAN ,  LI HENRY ,  KE NING ,  GRIFMAN MIRTA ,  ROGERS CHERYL ,  DEFIFE KRISTIN ,  HABITA CELLIA ,  FAN WUFANG ,  RHOADES KRISTINA ,  TAN PHILIP ,  TRITZ RICHARD ,  WONG-STAAL FLOSSIE

IPC分类号： C12Q1/68 ,  A61K20060101 ,  A61P35/00 ,  C12N15/113 ,  G01N33/50

CPC分类号： G01N33/5011 ,  C12N15/113 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2320/12 ,  C12Y114/19001 ,  C12Y207/01137 ,  C12Y207/11025 ,  C12Y301/04004 ,  C12Y402/01001 ,  G01N2510/00

摘要： The present invention is directed to methods of identifying agents useful for inhibiting cancer cells. The agents bind to one of the proteins described herein, or to a gene or mRNA encoding such protein. The invention is also directed to methods for inhibiting cancer cells by administering an agent that binds to one of the proteins described herein, or to a gene or mRNA encoding such protein.

摘要翻译： 另外，本发明涉及鉴定用于抑制肿瘤细胞中有用的药剂的方法。 所述试剂结合到描述于，或检查的基因或mRNA编码蛋白的蛋白之一。 因此，本发明涉及用于抑制由施用试剂没有结合于描述于，或检查的基因或mRNA编码蛋白的蛋白质的一种癌症细胞的方法。

公开(公告)号：EP1606300A4

公开(公告)日：2007-01-03

申请号：EP04709924

申请日：2004-02-10

申请人： IMMUSOL INC

发明人： LI HENRY ,  CHATTERTON JON E ,  FAN WUFANG ,  KE NING ,  WONG-STAAL FLOSSIE

IPC分类号： C12N15/11 ,  C12N15/113

CPC分类号： C12N15/111 ,  C12N15/1137 ,  C12N15/1138 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2330/31 ,  C12Y207/10001 ,  C12Y207/10002

摘要： siRNA Libraries Optimized for Predetermined Protein Families ABSTRACT Libraries for generating small inhibitory RNA (siRNA) are provided where the members of the library are optimized to inhibit the expression of genes that encode a predetermined family of proteins. The members of the library target at least mRNA encoding all members of the family of proteins. Methods for generating siRNA libraries of the present invention are also provided.