公开(公告)号：EP3231801B1

公开(公告)日：2019-02-13

申请号：EP17158350.3

申请日：2014-05-16

申请人： Incyte Corporation

发明人： LI, Yun-Long ,  ZHUO, Jincong ,  QIAN, Ding-Quan ,  MEI, Song ,  CAO, Ganfeng ,  PAN, Yongchun ,  LI, Qun ,  JIA, Zhongjiang

IPC分类号： C07D403/14 ,  A61K31/4155 ,  A61P37/00 ,  A61P35/00 ,  A61P29/00

公开(公告)号：EP2997023B1

公开(公告)日：2017-03-22

申请号：EP14732705.0

申请日：2014-05-16

申请人： Incyte Corporation

发明人： LI, Yun-Long ,  ZHUO, Jincong ,  QIAN, Ding-Quan ,  MEI, Song ,  CAO, Ganfeng ,  PAN, Yongchun ,  LI, Qun ,  JIA, Zhongjiang

IPC分类号： C07D403/14 ,  A61K31/4155 ,  A61P37/00 ,  A61P35/00 ,  A61P29/00

CPC分类号： C07D403/14

摘要： The present invention provides compounds of Formula I: or pharmaceutically acceptable salts thereof, as well as their compositions and methods of use, that inhibit the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

公开(公告)号：EP1979318A1

公开(公告)日：2008-10-15

申请号：EP07717107.2

申请日：2007-01-30

申请人： Incyte Corporation

发明人： LI, Yun-Long ,  YAO, Wenqing ,  ZHUO, Jincong

IPC分类号： C07D211/42 ,  C07D211/46 ,  C07D211/96 ,  C07D405/12 ,  C07D451/06 ,  C07D451/14 ,  C07D491/18 ,  C07D413/12 ,  A61K31/439 ,  A61P3/00 ,  A61P9/00 ,  A61K31/445

CPC分类号： C07D211/96 ,  C07D211/42 ,  C07D211/46 ,  C07D405/12 ,  C07D451/06 ,  C07D451/14

摘要： The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type l, as exemplified by formula (I).

公开(公告)号：EP3527263A1

公开(公告)日：2019-08-21

申请号：EP18215671.1

申请日：2014-05-16

申请人： Incyte Corporation

发明人： LI, Yun-Long ,  ZHUO, Jincong ,  QIAN, Ding-Quan ,  MEI, Song ,  CAO, Ganfeng ,  PAN, Yongchun ,  LI, Qun ,  JIA, Zhongjiang

IPC分类号： A61P37/06 ,  C07D403/14 ,  A61K31/4155

摘要： The present invention provides compounds of Formula I:

or pharmaceutically acceptable salts thereof, as well as their compositions and methods of use, that inhibit the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

公开(公告)号：EP2448938B9

公开(公告)日：2015-06-10

申请号：EP10729035.5

申请日：2010-06-28

申请人： Incyte Corporation

发明人： LI, Yun-Long ,  METCALF, Brian, W. ,  COMBS, Andrew, P.

IPC分类号： C07D473/34 ,  C07D513/04 ,  A61K31/52 ,  A61P29/00 ,  A61P37/00

CPC分类号： C07D519/00 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04

摘要： The present invention provides pyrimidinones that modulate activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.

公开(公告)号：EP1778229A2

公开(公告)日：2007-05-02

申请号：EP05790468.2

申请日：2005-08-09

申请人： INCYTE CORPORATION

发明人： YAO, Wenqing ,  ZHUO, Jincong ,  METCALF, Brian, W. ,  QIAN, Ding-Quan ,  LI, Yun-Long

IPC分类号： A61K31/44 ,  A61K31/47 ,  A61K31/54 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

CPC分类号： C07D451/06 ,  C07D211/56 ,  C07D211/96 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12 ,  C07D417/04

摘要： The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.

摘要翻译： 本发明涉及11-β羟基类固醇脱氢酶1型抑制剂，盐皮质激素受体（MR）拮抗剂及其药物组合物。 本发明化合物可用于治疗与11-β羟基类固醇脱氢酶1型的表达或活性有关的各种疾病和/或与醛固酮过量相关的疾病。

公开(公告)号：EP4321513A3

公开(公告)日：2024-05-08

申请号：EP23202364.8

申请日：2017-03-27

申请人： Incyte Corporation

发明人： LI, Yun-Long ,  WANG, Xiaozhao ,  BARBOSA, Joseph ,  BURNS, David M. ,  FENG, Hao ,  GLENN, Joseph ,  HE, Chunhong ,  HUANG, Taisheng ,  MEI, Song ,  ZHUO, Jincong

IPC分类号： C07D487/04 ,  A61P35/00 ,  A61K31/519 ,  C07D403/04

CPC分类号： A61K31/53 ,  C07D403/04 ,  C07D403/14 ,  A61P35/00 ,  C07D487/04

摘要： This application relates to compounds of Formula I:

or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are useful for the treatment of disorders such as cancer.

公开(公告)号：EP2997023B9

公开(公告)日：2018-06-13

申请号：EP14732705.0

申请日：2014-05-16

申请人： Incyte Corporation

发明人： LI, Yun-Long ,  ZHUO, Jincong ,  QIAN, Ding-Quan ,  MEI, Song ,  CAO, Ganfeng ,  PAN, Yongchun ,  LI, Qun ,  JIA, Zhongjiang

IPC分类号： C07D403/14 ,  A61K31/4155 ,  A61P37/00 ,  A61P35/00 ,  A61P29/00

CPC分类号： C07D403/14

摘要： The present invention provides compounds of Formula I: or pharmaceutically acceptable salts thereof, as well as their compositions and methods of use, that inhibit the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

公开(公告)号：EP3231801A1

公开(公告)日：2017-10-18

申请号：EP17158350.3

申请日：2014-05-16

申请人： Incyte Corporation

发明人： LI, Yun-Long ,  ZHUO, Jincong ,  QIAN, Ding-Quan ,  MEI, Song ,  CAO, Ganfeng ,  PAN, Yongchun ,  LI, Qun ,  JIA, Zhongjiang

IPC分类号： C07D403/14 ,  A61K31/4155 ,  A61P37/00 ,  A61P35/00 ,  A61P29/00

CPC分类号： C07D403/14

摘要： The present invention provides compounds of Formula I:

or pharmaceutically acceptable salts thereof, as well as their compositions and methods of use, that inhibit the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

摘要翻译： 本发明提供了抑制Janus激酶（JAK）活性并可用于治疗与JAK活性有关的疾病的式I化合物或其药学上可接受的盐及其组合物和使用方法，包括 例如炎性疾病，自身免疫性疾病，癌症和其他疾病。

公开(公告)号：EP2945939A1

公开(公告)日：2015-11-25

申请号：EP14702389.9

申请日：2014-01-14

申请人： Incyte Corporation

发明人： XUE, Chu-Biao ,  LI, Yun-Long ,  FENG, Hao ,  PAN, Jun ,  WANG, Anlai ,  ZHANG, Ke ,  YAO, Wenqing ,  ZHANG, Fenglei ,  ZHUO, Jincong

IPC分类号： C07D401/14 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/4427 ,  A61K31/4709 ,  A61K31/497 ,  A61P35/00

摘要： The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.