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公开(公告)号：EP1860119A4
公开(公告)日：2009-04-15
申请号：EP06714335
申请日：2006-02-22
发明人： AKAHORI YASUSHI , SUGIOKA ATSUSHI , HAYASHI NOBUHIRO , TAKASAKI AKIHIKO , SUZUKI KAZUHIRO , MORITA MIWA , KUROSAWA YOSHIKAZU , IBA YOSHITAKA , SUMITOMO MARIKO , TSUTSUMI SUSUMU , OGAWA KEIKO , MATSUDA KAZUKI , MURAMATSU CHIHO , TAKAHASHI NOBUHIRO , FUJIYAMA SARI , AZUMA MASACHIKA , UKAI YOSHINORI , MORISHITA KAZUHIRO
IPC分类号： C07K16/28 , A61K39/00 , A61P35/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12Q1/02 , G01N33/15 , G01N33/50
CPC分类号： C07K16/303 , A61K2039/505 , C07K16/2803 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2319/00 , G01N33/57426 , G01N33/57438
摘要： It is intended to clarify a molecule which is available as a target in treating or diagnosing cancer and utilize the molecule in the medical field or the research field. By treating IgSF4, which has been identified as a molecule specifically expressed in lung cancer cells, with an antibody, an ADCC activity is exerted. Based on this finding, an anti-IgSF4 antibody is provided as a means efficacious in treating cancer, etc.
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2.发明公开METHOD OF CLASSIFYING ANTIGEN, METHOD OF IDENTIFYING ANTIGEN, METHOD OF OBTAINING ANTIBODY OR ANTIBODY SET, METHOD OF CONSTRUCTING ANTIBODY PANEL AND ANTIBODY OR ANTIBODY SET AND USE OF THE SAME 有权分类程序的抗原，一种识别抗原，方法用于获得抗体面板施工和抗体或抗体SETS及其用途抗体或抗体SET，方法
公开(公告)号：EP2078732A4
公开(公告)日：2010-07-28
申请号：EP07790510
申请日：2007-07-09
发明人： SUGIOKA ATSUSHI , SUGIURA MOTOTAKA , AKAHORI YASUSHI , HAYASHI NOBUHIRO , TAKASAKI AKIHIKO , MORITA MIWA , KUROSAWA GENE , SUMITOMO MARIKO , TSUTSUMI SUSUMU , OGAWA KEIKO , MATSUDA KAZUKI , MURAMATSU CHIHO , SATOU NORIKO , AZUMA MASACHIKA , UKAI YOSHINORI , SUZUKI KAZUHIRO , KUROSAWA YOSHIKAZU , TANAKA MIHO , SHIRAISHI MAMORU
IPC分类号： C07K16/28 , C12N15/09 , C12Q1/02 , G01N33/574
CPC分类号： C07K16/30 , C07K16/005 , C07K16/28 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/303 , C07K16/32 , C07K16/40 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C12N15/1138 , C12N2310/14 , G01N33/57492 , G01N33/6854
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公开(公告)号：EP1433793A4
公开(公告)日：2006-01-25
申请号：EP02763029
申请日：2002-09-13
CPC分类号： C07K16/40 , C07K16/00 , C07K16/005 , C07K2317/22 , C07K2317/52 , C07K2317/569
摘要： It is intended to provide a camel antibody library sustaining the multiplicity in the antibody variable region genes in vivo in animals belonging to the family Camelidae. The multiplicity in the variable region genes in vivo can be achieved by, for example, mixing genes originating in a plural number of individuals or elaborating gene amplification conditions. Although VHH with restricted multiplicity repertory can be merely obtained by known methods, a library containing genes encoding functional VHH in a sufficiently large repertory size can be successfully provided. Thus, a library whereby VHH against an arbitrary antigen can be freely obtained is provided. VHH is excellent in solubility and stability and shows a reactivity which cannot be expected in case of conventional tetramer IgG.
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公开(公告)号：EP1429143A4
公开(公告)日：2006-04-12
申请号：EP02760625
申请日：2002-08-13
发明人： KUROSAWA YOSHIKAZU , AKAHORI YASUSHI , HIRONO YUKARI , KAKITA MAI , SUZUKI KAZUHIRO , OKUNO YOSHINOBU
IPC分类号： C07K16/00 , C07K16/10 , G01N33/53 , G01N33/536 , G01N33/543 , G01N33/50 , A61K39/395 , A61K45/00 , G01N33/15
CPC分类号： G01N33/54353 , C07K16/00 , C07K16/005 , C07K16/1018 , G01N33/53 , G01N33/5306 , G01N33/536
摘要： An affinitive linker is introduced into a target substance and captured by a binding partner capable of binding to the affinitive linker to thereby select a binding molecule capable of binding to the target substance. For example, a sugar chain contained in an influenza virus antigen is labeled with an affinitive linker such as biotin and allowed to bind to streptpavidin serving as a binding partner and then recovered. Thus, an antibody binding to the antigen can be easily concentrated. This method of selecting a binding molecule is useful in screening a neutralizer.
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