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    PEPTIDES OU CONJUGUES PEPTIDIQUES DERIVES DE LA MSH ET LEUR UTILISATION DANS LE TRAITEMENT COSMETIQUE DE LA CANITIE
    2.
    发明公开
    PEPTIDES OU CONJUGUES PEPTIDIQUES DERIVES DE LA MSH ET LEUR UTILISATION DANS LE TRAITEMENT COSMETIQUE DE LA CANITIE 有权
    MSH肽或肽KONJUGATDERIVATE及其用于美容抗衰白发（白发）

    公开(公告)号：EP1753781A1

    公开(公告)日：2007-02-21

    申请号：EP05770968.5

    申请日：2005-05-10

    申请人： INSTITUT EUROPEEN DE BIOLOGIE CELLULAIRE ,  Centre National de la Recherche Scientifique ,  Université de Montpellier I ,  Université Montpellier II

    发明人： HOCQUAUX, Michel ,  PINEL, Anne-Marie ,  MARTINEZ, Jean ,  SUBRA, Gilles

    IPC分类号： C07K14/685 ,  C07K7/06 ,  C07K5/04 ,  A61K47/48

    CPC分类号： A61K47/54

    摘要： The invention relates to a peptide of formula W-DPhe-Arg- Z (I) and to a conjugate thereof of a formula A-W-DPhe-Arg-Z (II), wherein A is a radical corresponding to a monocarboxylic acid of general formula HOOC-R (III), wherein R is an linear or branched possibly substituted by a hydroxy group aliphatic C1-C24 radical which can comprise one or several unsaturations, preferably from 1 to 6 unsaturations, a lipoic acid or the reduced form thereof, a dihydrolipoic acid, N-lipoyl-lysine or a phenylbutyric acid, W is His, Ala-His, Ala-Ala-His, Nle-Ala-His, DTrp-Ala-His, Nle-Trp-His, Lys, Ala-Lys, Nle-Ala-Lys, Orn, Ala-Orn, Nle-Ala-Orn, Ala, Nle-Ala-Ala, Arg, Ala-Arg, Nle-Ala-Arg, Nle-Ala-DTrp or a bond in case of compounds of formula (II), Z is NH2, OH and OR, wherein R is a linear or branched aliphatic C1-C24 radical, TrpNH2, NapNH2, TpiNH2, TicNH2, AlaNH2i TrpOH, NapOH, TpiOH, TicOH, AlaOH, PheNH2, or PheOH, exempting a peptidic conjugate for which A is a radical corresponding to an acetic acid, W is Nle-Ala-His and Z is TrpNH2 in the form of enantiomers or diastereoisomer and the mixtures thereof including racemic mixtures. The use of the inventive compounds for cosmetically fighting against canities is also disclosed.