公开(公告)号：EP0760811B1

公开(公告)日：2009-11-18

申请号：EP96908172.8

申请日：1996-03-21

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  SOCIETE CIVILE BIOPROJET

发明人： SCHWARTZ, Jean-Charles ,  ARRANG, Jean-Michel ,  GARBARG, Monique ,  QUEMENER, Agnès ,  LECOMTE, Jeanne-Marie ,  LIGNEAU, Xavier ,  SCHUNACK, Walter, G. ,  STARK, Holger ,  PURAND, Katja ,  HÜLS, Annette ,  REIDEMEISTER, Sybille ,  ATHMANI, Salah ,  GANELLIN, Charon, Robin ,  PELLOUX-LEON, Nadia ,  TERTIUX, Wasyl ,  KRAUSE, Michael, C., O. ,  BASSEM, Sadek

IPC分类号： C07D233/64 ,  C07D409/12 ,  C07D401/12 ,  C07D405/12 ,  C07D411/12 ,  C07D413/12 ,  A61K31/415

CPC分类号： C07D233/56 ,  C07D233/64 ,  C07D405/12 ,  C07D409/12 ,  C07D411/12 ,  C07D413/12 ,  G01N33/567 ,  G01N33/74 ,  G01N2333/726

摘要： Novel imidazole derivatives as histamine receptor H3 antagonists and/or agonists, preparation thereof and therapeutical uses thereof. Chemical compounds for use as histamine receptor H3 agonists, partial agonists or antagonists, having general formula (Ia) or (Ib), the use thereof for making drugs, and methods for revealing the agonist, partial agonist or antagonist activity of such compounds in vivo, are disclosed.

公开(公告)号：EP0760811A1

公开(公告)日：1997-03-12

申请号：EP96908172.0

申请日：1996-03-21

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  SOCIETE CIVILE BIOPROJET

发明人： SCHWARTZ, Jean-Charles ,  ARRANG, Jean-Michel ,  GARBARG, Monique ,  QUEMENER, Agnès ,  LECOMTE, Jeanne-Marie ,  LIGNEAU, Xavier ,  SCHUNACK, Walter, G. ,  STARK, Holger ,  PURAND, Katja ,  HÜLS, Annette ,  REIDEMEISTER, Sybille ,  ATHMANI, Salah ,  GANELLIN, Charon, Robin ,  PELLOUX-LEON, Nadia ,  TERTIUX, Wasyl ,  KRAUSE, Michael, C., O. ,  BASSEM, Sadek

IPC分类号： G01N33 ,  A61K31 ,  A61P1 ,  A61P7 ,  A61P9 ,  A61P11 ,  A61P13 ,  A61P15 ,  A61P17 ,  A61P25 ,  A61P27 ,  A61P29 ,  A61P37 ,  A61P43 ,  C07D233 ,  C07D401 ,  C07D405 ,  C07D409 ,  C07D411 ,  C07D413

CPC分类号： C07D233/56 ,  C07D233/64 ,  C07D405/12 ,  C07D409/12 ,  C07D411/12 ,  C07D413/12 ,  G01N33/567 ,  G01N33/74 ,  G01N2333/726

摘要： Novel imidazole derivatives as histamine receptor H3 antagonists and/or agonists, preparation thereof and therapeutical uses thereof. Chemical compounds for use as histamine receptor H3 agonists, partial agonists or antagonists, having general formula (Ia) or (Ib), the use thereof for making drugs, and methods for revealing the agonist, partial agonist or antagonist activity of such compounds in vivo, are disclosed.