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1.发明授权
公开(公告)号：EP1677815B8
公开(公告)日：2017-08-30
申请号：EP04769635.6
申请日：2004-09-24
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE -CNRS-
发明人： AGOU, Fabrice , COURTOIS, Gilles , ISRAEL, Alain , VERON, Michel , TRAINCARD, François , YAMAOKA, Shoji , BALEUX, Francoise , COÏC, Yves-Marie
IPC分类号： A61K38/17
CPC分类号： C07K14/4702 , A61K38/00 , C07K2319/01
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2.发明公开SELECTIVE INHIBITION OF NF-KAPPAB ACTIVATION BY PEPTIDES DESIGNED TO DISRUPT NEMO OLIGOMERIZATION. 有权对灭失NEMO的寡聚化NF-KAPPA-激活肽选择性抑制
公开(公告)号：EP1677815A1
公开(公告)日：2006-07-12
申请号：EP04769635.6
申请日：2004-09-24
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人： AGOU, Fabrice , COURTOIS, Gilles , ISRAEL, Alain , VERON, Michel , TRAINCARD, François , YAMAOKA, Shoji , BALEUX, Francoise
IPC分类号： A61K38/17
CPC分类号： C07K14/4702 , A61K38/00 , C07K2319/01
摘要： The present invention relates to polypeptides that inhibit the NF-κB signaling pathway and polynucleotides encoding the same. The present invention further provides methods for the modulation of and/or treatment of inflammatory responses, oncogenesis, viral infection; the regulation of cell proliferation and apoptosis; and regulation of B or T lymphocytes in antigenic stimulation, by administering the polypeptides of the present invention to a subject in need thereof. Finally, the present invention provides a method of identifying polypeptides that modulate oligomerization of NEMO.
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3.发明授权SELECTIVE INHIBITION OF NF-KAPPAB ACTIVATION BY PEPTIDES DESIGNED TO DISRUPT NEMO OLIGOMERIZATION. 有权设计破坏NEMO低聚化的肽对NF-KAPPAB活化的选择性抑制。
公开(公告)号：EP1677815B1
公开(公告)日：2017-05-31
申请号：EP04769635.6
申请日：2004-09-24
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE -CNRS-
发明人： AGOU, Fabrice , COURTOIS, Gilles , ISRAEL, Alain , VERON, Michel , TRAINCARD, François , YAMAOKA, Shoji , BALEUX, Francoise
IPC分类号： A61K38/17
CPC分类号： C07K14/4702 , A61K38/00 , C07K2319/01
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4.发明公开
公开(公告)号：EP3394088A1
公开(公告)日：2018-10-31
申请号：EP16825755.8
申请日：2016-12-22
申请人： Institut Pasteur
摘要： The invention concerns stapled peptide inhibitors of NEMO which inhibit the Nuclear Factor ºB (NF-ºB) signaling pathway and are useful as medicine candidates, in particular as anti-inflammatory or anticancer drugs.
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5.发明公开STAPLED PEPTIDE INHIBITORS OF NEMO AS POTENTIAL ANTI-INFLAMMATORY AND ANTI-CANCER DRUGS 审中-公开NEMO作为潜在抗炎药和抗癌药的标准肽抑制剂
公开(公告)号：EP3184541A1
公开(公告)日：2017-06-28
申请号：EP15307137.8
申请日：2015-12-23
申请人： Institut Pasteur
CPC分类号： C07K14/4702 , C07K2319/03
摘要： The invention concerns stapled peptide inhibitors of NEMO which inhibit the Nuclear Factor κB (NF-κB) signaling pathway and are useful as medicine candidates, in particular as anti-inflammatory or anticancer drugs.
摘要翻译： 本发明涉及NEMO的钉合肽抑制剂，其抑制核因子κB（NF-κB）信号传导途径并且可用作药物候选物，特别是作为抗炎或抗癌药物。
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公开(公告)号：EP2240513A2
公开(公告)日：2010-10-20
申请号：EP09722579.1
申请日：2009-02-05
发明人： AGOU, Fabrice , CHIARAVALLI, Jeanne , DUQUERROY, Stéphane , FONTAN, Elisabeth , GRUBISHA, Olivera , KAMINSKA, Monika Dorota , VERON, Michel , CORDIER, Florence
CPC分类号： C07K14/4702 , C07K2299/00 , G01N33/6803 , G01N33/6872 , G06F19/16
摘要： The invention relates to a crystal of the CC2-LZ domain of the NEMO protein, in which the three-dimensional structure has been determined by X-ray diffraction at a resolution of about 3.25 A. The invention also relates to methods for the crystallisation of the CC2-LZ domain. The CC2-LZ crystals and the information derived from the crystalline structures thereof are used for identifying and designing compounds interacting with CC2-LZ.
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8.发明公开METHOD FOR SCREENING FOR SELECTIVE MODULATOR OF THE NF- B PATHWAY ACTIVATION 审中-公开筛选方法，通过NF-κB活化通路的选择性调节剂
公开(公告)号：EP2174141A2
公开(公告)日：2010-04-14
申请号：EP08807211.1
申请日：2008-06-20
发明人： AGOU, Fabrice , CHIARAVALLI, Jeanne , COIC, Yves-Marie , BALEUX, Françoise , ISRAEL, Alain , VERON, Michel
IPC分类号： G01N33/68
CPC分类号： G01N33/6872 , G01N2500/00
摘要： The invention relates to methods for screening for selective modulator of NF-ϰB pathway activation. The invention concerns methods for primary screening molecules that potentially modulate (activate or inhibit) the NF-ϰB pathway activation by identifying and selecting molecules modulate the interaction of NEMO with other proteins. The invention also concerns methods for secondary screening for modulator (activator or inhibitor) of the NF-ϰB pathway activation.
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