专利检索 ap:("Les Laboratoires Servier" OR "INSTITUT PASTEUR") AND inv:"CHIARAVALLI, Jeanne" 第 1 页

1.

发明公开
STRUCTURE CRISTALLINE DU DOMAINE CC2-LZ DE NEMO 审中-公开
标题翻译：晶体结构尼莫CC2-LZ结构域

公开(公告)号：EP2240513A2

公开(公告)日：2010-10-20

申请号：EP09722579.1

申请日：2009-02-05

申请人： Les Laboratoires Servier , INSTITUT PASTEUR

发明人： AGOU, Fabrice , CHIARAVALLI, Jeanne , DUQUERROY, Stéphane , FONTAN, Elisabeth , GRUBISHA, Olivera , KAMINSKA, Monika Dorota , VERON, Michel , CORDIER, Florence

IPC分类号： C07K14/47 , C12N15/09 , A61K38/17 , G06F17/50 , B01D9/02 , G01N23/223 , G01N33/68

CPC分类号： C07K14/4702 , C07K2299/00 , G01N33/6803 , G01N33/6872 , G06F19/16

摘要： The invention relates to a crystal of the CC2-LZ domain of the NEMO protein, in which the three-dimensional structure has been determined by X-ray diffraction at a resolution of about 3.25 A. The invention also relates to methods for the crystallisation of the CC2-LZ domain. The CC2-LZ crystals and the information derived from the crystalline structures thereof are used for identifying and designing compounds interacting with CC2-LZ.

2.

发明公开
METHOD FOR SCREENING FOR SELECTIVE MODULATOR OF THE NF- B PATHWAY ACTIVATION 审中-公开
标题翻译：筛选方法，通过NF-κB活化通路的选择性调节剂

公开(公告)号：EP2174141A2

公开(公告)日：2010-04-14

申请号：EP08807211.1

申请日：2008-06-20

申请人： Institut Pasteur , Centre National de la Recherche Scientifique

发明人： AGOU, Fabrice , CHIARAVALLI, Jeanne , COIC, Yves-Marie , BALEUX, Françoise , ISRAEL, Alain , VERON, Michel

IPC分类号： G01N33/68

CPC分类号： G01N33/6872 , G01N2500/00

摘要： The invention relates to methods for screening for selective modulator of NF-ϰB pathway activation. The invention concerns methods for primary screening molecules that potentially modulate (activate or inhibit) the NF-ϰB pathway activation by identifying and selecting molecules modulate the interaction of NEMO with other proteins. The invention also concerns methods for secondary screening for modulator (activator or inhibitor) of the NF-ϰB pathway activation.

3.

发明公开
6-6 OR 5-6 FUSED BICYCLIC COMPOUNDS COMPRISING A PYRI(MI)DINE RING USEFUL IN THE TREATMENT OF INFECTIOUS DISEASES 审中-公开

公开(公告)号：EP4263539A1

公开(公告)日：2023-10-25

申请号：EP21831052.2

申请日：2021-12-16

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM , Ecole Polytechnique , UNIVERSITE DE BORDEAUX , Institut Pasteur , Centre National de la Recherche Scientifique

发明人： CHIARAVALLI, Jeanne , GUILLON, Jean , LAVIGNE, Marc , MUNIER-LEHMANN, Hélène , MERGNY, Jean-Louis , MEYER, Björn , SAVRIMOUTOU, Solène

IPC分类号： C07D471/04 , C07D473/00 , C07D473/40 , C07D487/04 , C07D495/04 , A61P31/12 , A61P33/00 , A61K31/519