公开(公告)号：EP1363662A2

公开(公告)日：2003-11-26

申请号：EP02708352.6

申请日：2002-02-26

申请人： INSTITUT PASTEUR ,  INSTITUT NATIONAL DE LA SANTE ETDE LA RECHERCHE MEDICALE (INSERM) ,  CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： SCHWARTZ, Olivier ,  BUSEYNE, Florence ,  MARSAC, Delphine ,  MICHEL, Marie-Louise ,  RIVIERE, Yves ,  HEARD, Jean-Michel

IPC分类号： A61K39/21 ,  C07K14/15 ,  C07K14/155 ,  C07K14/16 ,  C12N7/04 ,  G01N33/50

CPC分类号： G01N33/567 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/5258 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/005 ,  C12N7/00 ,  C12N2740/16023 ,  C12N2740/16034 ,  C12N2740/16062 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2740/16234 ,  C12N2760/20222 ,  C12N2760/20234 ,  G01N33/505 ,  G01N33/5082 ,  G01N2333/16

摘要： Dendritic cells and macrophages can process extracellular antigens for presentation by MHC-I molecules. HIV-1 epitopes derived from incoming virions are presented through the exogenous MHC-I pathway in primary human dendritic cells, and to a lower extent in macrophages, leading to cytotoxic T lymphocyte activation in the absence of viral protein neosynthesis. Exogenous antigen presentation required adequate virus-receptor interactions and fusion of viral and cellular membranes. These results provide new insights about how anti-HIV cytotoxic T lymphocytes can be activated and are useful for anti-HIV vaccine design.