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    EX VIVO MODEL FOR NEURODEGENERATIVE DISEASES
    3.
    发明公开
    EX VIVO MODEL FOR NEURODEGENERATIVE DISEASES 审中-公开

    公开(公告)号：EP3382005A2

    公开(公告)日：2018-10-03

    申请号：EP18165193.6

    申请日：2018-03-29

    Applicant: Neuro-Bio Ltd

    Inventor： GREENFIELD, Susan ,  BRAI, Emanuele

    IPC: C12M3/00 ,  G01N33/50 ,  C12M1/04

    CPC classification number: G01N33/5082 ,  C12M1/04 ,  C12M21/08

    Abstract: The invention relates to animal models, and in particular to novel ex-vivo animal models for investigating the underlying mechanisms occurring in neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease or Motor Neurone Disease. The invention extends to apparatus, methods and assays for providing such models, as well as for testing pharmacological compounds, which may regulate neurological processes, and for drug screening for use in treating neurodegenerative disease. The invention also relates to novel polypeptides, peptidomimetics and compositions, for use in the assays and apparatus used to investigate neurodegenerative disorders, and for drug screening. The invention also relates to apparatus and methods for animal models for investigating neuroregeneration.

    METHOD TO EVALUATE THE TISSUE TARGETING OF A MOLECULE OF INTEREST
    4.
    发明授权
    METHOD TO EVALUATE THE TISSUE TARGETING OF A MOLECULE OF INTEREST 有权

    公开(公告)号：EP2959294B1

    公开(公告)日：2018-08-08

    申请号：EP14706597.3

    申请日：2014-02-25

    Applicant: Imabiotech

    Inventor： HAMM, Grégory ,  STAUBER, Jonathan

    IPC: G01N33/50

    CPC classification number: G01N33/5035 ,  A61K49/0008 ,  G01N33/5082

    Abstract: The invention relates to a method for evaluating whether a molecule of interest binds or is incorporated in at least one target tissue, comprising visualizing and comparing the distribution of the molecule of interest and of at least one control compound within the target tissue or on the target tissue surface of at least one animal that has previously received the molecule of interest and/or the control compound. Advantageously, the distribution of the molecule of interest is visualized and compared with the distribution of positive and negative compounds using mass spectrometry imaging on the surface of the target tissue.

    METHODS FOR MEASUREMENT OF INHIBITION OF C-JUN N-TERMINAL KINASE IN SKIN
    8.
    发明公开
    METHODS FOR MEASUREMENT OF INHIBITION OF C-JUN N-TERMINAL KINASE IN SKIN 审中-公开
    测定皮肤中C-Jun N-末端激酶抑制作用的方法

    公开(公告)号：EP3233808A1

    公开(公告)日：2017-10-25

    申请号：EP15870855.2

    申请日：2015-12-15

    Applicant: Signal Pharmaceuticals, LLC

    Inventor： HORAN, Gerald Scott Barden ,  YE, Ying

    IPC: C07D239/48

    CPC classification number: G01N33/6881 ,  A61K9/0053 ,  A61K31/505 ,  G01N33/5008 ,  G01N33/5082 ,  G01N2333/4706 ,  G01N2333/91205 ,  G01N2440/14 ,  G01N2800/20 ,  G01N2800/52

    Abstract: Provided herein are methods for evaluating the effect of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide or a pharmaceutically acceptable stereoisomer, tautomer, solid form, polymorph, salt, hydrate, clathrate, or solvate thereof in a patient with an assay based on UVB-irradiation and phosphorylated c-Jun expression. The analyzes allow for evaluation of dose-response and identification of patient populations who are sensitive to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide or a pharmaceutically acceptable stereoisomer, tautomer, solid form, polymorph, salt, hydrate, clathrate, or solvate thereof.

    Abstract translation: 本文提供评估2-（叔丁基氨基）-4（（1R，3R，4R）-3-羟基-4-甲基环己基氨基） - 嘧啶-5-甲酰胺或其药学上可接受的立体异构体，互变异构体， 固体形式，多晶型物，盐，水合物，包合物或溶剂合物与基于UVB-辐照和磷酸化c-Jun表达的测定法相结合的患者。 该分析允许评估对2-（叔丁基氨基）-4 - （（1R，3R，4R）-3-羟基-4-甲基环己基氨基） - 嘧啶-5-甲酰胺敏感的患者群的剂量反应和鉴定。 甲酰胺或其药学上可接受的立体异构体，互变异构体，固体形式，多晶型物，盐，水合物，包合物或溶剂合物。

    SYNTHETIC SKIN
    9.
    发明公开
    SYNTHETIC SKIN 审中-公开
    合成皮肤

    公开(公告)号：EP3158555A1

    公开(公告)日：2017-04-26

    申请号：EP15732876.6

    申请日：2015-06-23

    Applicant: The Secretary of State for Defence

    Inventor： GAZI, Ehsan ,  FRANCIS, David Clive ,  SHORTMAN, Ian Michael ,  EDE, Jayne Alexandra

    IPC: G09B23/28 ,  B29C33/42

    CPC classification number: G01N33/5082

    Abstract: A method of producing a synthetic skin comprising depositing a curable polymer on a non-biological material having a rough surface, curing the polymer and then removing the non-biological material from the cured polymer to provide a synthetic skin. The rough surface is imprinted onto the polymer and may be an abrasive surface such as sandpaper of various coarse grades. The rough surface may be pre-coated with a non-stick substance such as silicon dioxide liquid glass. The curable polymer is preferably silicone. The resulting synthetic skin may have hair embedded into it and may be used as a physical model for the testing of chemical agents.

    Abstract translation: 一种生产合成表皮的方法，包括将可固化聚合物沉积在具有粗糙表面的非生物材料上，固化聚合物，然后从固化聚合物中除去非生物材料以提供合成表皮。 粗糙的表面印在聚合物上，可能是一种研磨表面，如各种粗糙等级的砂纸。 粗糙表面可以用诸如二氧化硅液体玻璃之类的不粘物质预涂布。 可固化聚合物优选为硅酮。 所得到的合成皮肤可以具有嵌入其中的毛发并且可以用作化学试剂测试的物理模型。

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