公开(公告)号：EP3013960A4

公开(公告)日：2017-02-15

申请号：EP14817914

申请日：2014-06-26

申请人： THE UNIV OF WESTERN ONTARIO

发明人： KANG CHIL-YONG ,  KIM GYOUNG NYOUN

IPC分类号： C12N15/47 ,  A61K39/205 ,  A61K39/21 ,  A61K39/295 ,  A61K39/39 ,  A61P31/14 ,  A61P37/04 ,  C07K14/145 ,  C12N7/01

CPC分类号： A61K39/39 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/545 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2740/16034 ,  C12N2760/20222 ,  C12N2760/20234 ,  C12N2760/20243 ,  C12N2770/24234

摘要： The present invention relates to vesicular stomatitis virus (VSV) matrix (M) protein mutants. One mutant M protein includes a glycine changed to a glutamic acid at position (21), a leucine changed to alanine at position (111) and a methionine changed to an arginine at position (51). Another M protein mutant includes a glycine changed to a glutamic acid at position (22) and a methionine changed to an arginine at positions (48) and (51). These new rVSVs having the mutant M are significantly attenuated and lost virulence, including neurovirulence, and are capable of inducing an immune responses against an antigen of interest. In addition, a rVSV serotype Indiana having the first described M mutant is capable of efficient replication at 31° C., and of poor replication or incapable of replication at about 37° C. or higher.

公开(公告)号：EP3113795A2

公开(公告)日：2017-01-11

申请号：EP15758863.3

申请日：2015-02-27

申请人： The Board of Regents of The University of Texas System ,  Profectus Biosciences, Inc.

发明人： MATASSOV, Demetrius ,  GORCHAKOV, Rodion, V. ,  HAMM, Stefan ,  NOWAK, Rebecca ,  SEYMOUR, Robert, L. ,  ELDRIDGE, John, H. ,  TESH, Robert, B. ,  CLARKE, David, K. ,  LATHAM, Theresa, E. ,  WEAVER, Scott ,  NASAR, Farooq

IPC分类号： A61K39/12 ,  C12N15/00

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/5256 ,  A61K2039/545 ,  C12N15/86 ,  C12N2740/16071 ,  C12N2740/16234 ,  C12N2760/20221 ,  C12N2760/20222 ,  C12N2760/20243 ,  C12N2760/20262 ,  C12N2760/20271 ,  C12N2770/36134 ,  C12N2770/36171 ,  Y02A50/383

摘要： Certain embodiments are directed to recombinant vesiculovirus encoding a heterologous polynucleotide and methods of using the same.

摘要翻译： 某些实施方案涉及编码异源多核苷酸的重组囊状病毒及其使用方法。

公开(公告)号：EP3008192A4

公开(公告)日：2016-12-28

申请号：EP14810531

申请日：2014-05-15

申请人： TAKARA BIO USA INC

发明人： HAUGWITZ MICHAEL ,  QUINN THOMAS PATRICK ,  FARMER ANDREW ALAN ,  MORELL FERNANDEZ MONTSERRAT

IPC分类号： C12N15/88 ,  C12N15/09 ,  C12N15/63

CPC分类号： C12N5/0602 ,  C07K14/005 ,  C07K14/43595 ,  C07K17/06 ,  C07K2319/00 ,  C07K2319/70 ,  C12N5/00 ,  C12N9/003 ,  C12N9/1241 ,  C12N2501/998 ,  C12N2760/00022 ,  C12N2760/20222 ,  C12P21/02 ,  C12Y105/01003

摘要： Protein enriched micro-vesicles and methods of making and using the same are provided. Aspects of the methods include maintaining a cell having a membrane-associated protein comprising a first dimerization domain and a target protein having a second dimerization domain under conditions sufficient to produce a micro-vesicle from the cell, wherein the micro-vesicle includes the target protein. Also provided are cells, reagents and kits that find use in making the micro-vesicles, as well as methods of using the micro-vesicles, e.g., in research and therapeutic applications.

公开(公告)号：EP2935569A4

公开(公告)日：2016-08-03

申请号：EP13865170

申请日：2013-12-20

申请人： CELVERUM INC

发明人： CONRAD DAVID ,  BATENCHUK CORY ,  LEBOEUF FABRICE ,  BELL JOHN CAMERON

IPC分类号： A61K35/76 ,  A61P35/00 ,  C12N7/06

CPC分类号： A61K35/766 ,  A61K45/06 ,  C07K14/005 ,  C12N7/00 ,  C12N7/045 ,  C12N7/06 ,  C12N2760/20021 ,  C12N2760/20032 ,  C12N2760/20061 ,  C12N2760/20222 ,  C12N2760/20232 ,  C12N2760/20261 ,  C12N2760/20263 ,  A61K2300/00

摘要： There is described herein a non-replicating Rhabdovirus-derived particle that lacks the ability to spread between cells while having tropism against immortalized cells. The non-replicating Rhabdovirus-derived particle may have cytolytic tropism against immortalized cells. There is also described a non-replicating Rhabdovirus-derived particle that lacks the ability to spread between cells but has innate and/or adaptive immune-stimulating properties.

公开(公告)号：EP3047025A1

公开(公告)日：2016-07-27

申请号：EP14796166.8

申请日：2014-09-12

申请人： Genethon

发明人： FENARD, David

IPC分类号： C12N15/86

CPC分类号： C12N7/00 ,  C07K14/005 ,  C12N15/86 ,  C12N2740/13022 ,  C12N2740/15043 ,  C12N2740/15045 ,  C12N2740/15051 ,  C12N2740/15052 ,  C12N2740/16021 ,  C12N2740/16043 ,  C12N2740/16051 ,  C12N2760/20222

摘要： The invention concerns a method for producing enveloped viruses in a mildly acidic medium. The methods of the invention can be used for producing and recovering enveloped viruses on a large scale under conditions that comply with good manufacturing practice (or GMP).

摘要翻译： 本发明涉及一种在轻度酸培养基中产生包膜病毒的方法。 本发明的方法可用于在观察良好制造实践（或GMP）的条件下在大规模包膜病毒下生产和回收。

公开(公告)号：EP2935569A1

公开(公告)日：2015-10-28

申请号：EP13865170.8

申请日：2013-12-20

申请人： Ottawa Hospital Research Institute

发明人： CONRAD, David ,  BATENCHUK, Cory ,  LEBOEUF, Fabrice ,  BELL, John Cameron

IPC分类号： C12N7/06 ,  A61K35/76 ,  A61P35/00

CPC分类号： A61K35/766 ,  A61K45/06 ,  A61P35/02 ,  C07K14/005 ,  C12N7/00 ,  C12N7/045 ,  C12N7/06 ,  C12N2760/20021 ,  C12N2760/20032 ,  C12N2760/20061 ,  C12N2760/20222 ,  C12N2760/20232 ,  C12N2760/20261 ,  C12N2760/20263 ,  A61K2300/00

摘要： There is described herein a non-replicating Rhabdovirus-derived particle that lacks the ability to spread between cells while having tropism against immortalized cells. The non-replicating Rhabdovirus-derived particle may have cytolytic tropism against immortalized cells. There is also described a non-replicating Rhabdovirus-derived particle that lacks the ability to spread between cells but has innate and/or adaptive immune-stimulating properties.

公开(公告)号：EP2794637A4

公开(公告)日：2015-09-30

申请号：EP12859997

申请日：2012-12-21

申请人： UNIV WESTERN ONTARIO

发明人： KANG CHIL-YONG ,  KIM GYOUNG NYOUN

IPC分类号： C07K14/145 ,  A61K39/205 ,  A61K39/295 ,  A61P31/14 ,  A61P37/04 ,  C12N7/01 ,  C12N15/47

CPC分类号： A61K39/39 ,  A61K39/12 ,  A61K39/205 ,  A61K39/21 ,  A61K39/29 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/545 ,  A61K2039/55516 ,  A61K2039/57 ,  A61K2039/575 ,  C07K14/005 ,  C12N7/00 ,  C12N7/04 ,  C12N2740/16071 ,  C12N2740/16134 ,  C12N2740/16171 ,  C12N2740/16234 ,  C12N2740/16271 ,  C12N2740/16334 ,  C12N2760/20221 ,  C12N2760/20222 ,  C12N2760/20234 ,  C12N2760/20243 ,  C12N2760/20262 ,  C12N2760/20271 ,  C12N2770/24234 ,  C12N2770/24271

公开(公告)号：EP1756287B1

公开(公告)日：2015-02-25

申请号：EP05763601.1

申请日：2005-04-05

申请人： Wyeth LLC

发明人： CLARKE, David, Kirkwood ,  HENDRY, Roger, Michael ,  UDEM, Stephen, A. ,  PARKS, Christopher, Lee

IPC分类号： C12N7/04 ,  A61K39/21 ,  C07K14/005 ,  C12N15/86

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/545 ,  C12N7/00 ,  C12N15/86 ,  C12N2740/16234 ,  C12N2760/20222 ,  C12N2760/20243 ,  C12N2760/20264 ,  Y02A50/466

摘要： The present invention broadly relates to the synergistic attenuation of vesicular stomatitis virus (VSV). More particularly, the invention relates to the identification of combined mutation classes which synergistically attenuate the pathogenicity of VSV vectors in mammals and immunogenic compositions thereof.

公开(公告)号：EP1851315B1

公开(公告)日：2013-12-25

申请号：EP06720126.9

申请日：2006-02-02

申请人： University of Massachusetts ,  Centers for Disease Control and Prevention

发明人： THOMAS, William D., Jr. ,  AMBROSINO, Donna ,  MANDELL, Robert ,  SCHONHOFF, Susan ,  BABCOCK, Gregory J. ,  RUPPRECHT, Charles

IPC分类号： C12N15/13 ,  C12N5/10 ,  C07K16/10 ,  C07K14/145 ,  A61K39/395 ,  A61K39/205 ,  A61P31/14 ,  G01N33/53

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/205 ,  A61K39/42 ,  A61K2039/507 ,  C07K16/10 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/30 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/92 ,  C12N2760/20222 ,  C12N2760/20234

公开(公告)号：EP2508599A4

公开(公告)日：2013-06-26

申请号：EP10834471

申请日：2010-11-11

申请人： JAPAN SCIENCE & TECH AGENCY

发明人： KOBAYASHI KAZUTO

IPC分类号： C12N15/00 ,  A61K35/76 ,  A61K38/00 ,  A61K48/00 ,  A61P25/16 ,  C07K14/145 ,  C07K14/16 ,  C12N5/10 ,  C12N7/02 ,  C12N15/09

CPC分类号： A61K48/0075 ,  C07K14/005 ,  C12N15/86 ,  C12N2740/16045 ,  C12N2740/16052 ,  C12N2760/20122 ,  C12N2760/20222 ,  C12N2810/6081