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1.发明公开COMPOSITION COMPRENANT LA REGION N-TERMINALE D'HISTONE H2B DE LEISHMANIA - UTILISATION POUR INDUIRE UNE REPONSE IMMUNITAIRE 有权物组成热的N-利什曼-组蛋白H2B区域，并将其用于确保免疫应答
公开(公告)号：EP1858549A2
公开(公告)日：2007-11-28
申请号：EP06743593.3
申请日：2006-03-17
发明人： CHENIK, Mehdi , LOUZIR, Hechmi , DELLAGI, Koussay
IPC分类号： A61K39/008 , C07K14/44
CPC分类号： C07K14/44 , A61K39/008 , A61K2039/55561 , Y02A50/41
摘要： The invention concerns an immunogenic composition comprising: i) an antigenic polypeptide consisting of a fragment of the protein histone H2B of Leishmania, said fragment including the N-terminal region of said protein histone H2B, and ii) an adjuvant stimulating the immune response.
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2.发明公开POLYPEPTIDES OF LEISHMANIA MAJOR AND POLYNUCLEOTIDES ENCODING SAME AND VACCINAL, THERAPEUTICAL AND DIAGNOSTIC APPLICATIONS THEREOF 有权主要多肽确保两利什曼CODING多核苷酸，及其作为疫苗和诊断治疗学
公开(公告)号：EP1869073A2
公开(公告)日：2007-12-26
申请号：EP06724635.5
申请日：2006-04-07
发明人： CHENIK, Mehdi , LAKHAL, Sami , LOUZIR, Hechmi , DELLAGI, Koussay
IPC分类号： C07K14/435
CPC分类号： C07K14/44 , A61K38/00 , G01N33/56905 , Y02A50/41 , Y02A50/473 , Y02A50/55
摘要： The present invention relates to new proteins of Leishmania major and to therapeutical and diagnostic applications thereof. More particularly, the present invention relates to excreted/secreted polypeptides and polynucleotides encoding same, compositions comprising the same, and methods of diagnosis, vaccination and treatment of Leishmaniasis.
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3.发明授权COMPOSITION COMPRENANT LA REGION N-TERMINALE D'HISTONE H2B DE LEISHMANIA - UTILISATION POUR INDUIRE UNE REPONSE IMMUNITAIRE 有权物组成热的N-利什曼-组蛋白H2B区域，并将其用于确保免疫应答
公开(公告)号：EP1858549B1
公开(公告)日：2013-10-02
申请号：EP06743593.3
申请日：2006-03-17
发明人： CHENIK, Mehdi , LOUZIR, Hechmi , DELLAGI, Koussay
IPC分类号： A61K39/008 , C07K14/44
CPC分类号： C07K14/44 , A61K39/008 , A61K2039/55561 , Y02A50/41
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4.发明授权POLYPEPTIDES OF LEISHMANIA MAJOR AND POLYNUCLEOTIDES ENCODING SAME AND VACCINAL, THERAPEUTICAL AND DIAGNOSTIC APPLICATIONS THEREOF 有权主要多肽确保两利什曼CODING多核苷酸，及其作为疫苗和诊断治疗学
公开(公告)号：EP1869073B1
公开(公告)日：2011-08-17
申请号：EP06724635.5
申请日：2006-04-07
发明人： CHENIK, Mehdi , LAKHAL, Sami , LOUZIR, Hechmi , DELLAGI, Koussay
IPC分类号： C07K14/435
CPC分类号： C07K14/44 , A61K38/00 , G01N33/56905 , Y02A50/41 , Y02A50/473 , Y02A50/55
摘要： The present invention relates to new proteins of Leishmania major and to therapeutical and diagnostic applications thereof. More particularly, the present invention relates to excreted/secreted polypeptides and polynucleotides encoding same, compositions comprising the same, and methods of diagnosis, vaccination and treatment of Leishmaniasis.
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公开(公告)号：EP1414967B1
公开(公告)日：2015-04-15
申请号：EP02751257.3
申请日：2002-06-17
IPC分类号： C12N15/30 , C12N9/90 , C07K14/44 , G01N33/50 , G01N33/569 , G01N33/573 , C07K16/40 , C07K16/20 , C12Q1/68 , A61K39/00
CPC分类号： C12N9/90 , A61K2039/523 , A61K2039/57 , C07K2319/00 , Y02A50/41
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公开(公告)号：EP1414967A2
公开(公告)日：2004-05-06
申请号：EP02751257.3
申请日：2002-06-17
发明人： BEN ACHOUR, Yosser , CHENIK, Mehdi , LOUZIR, Hechmi , DELLAGI, Koussay,Institut Pasteur de Tunis
IPC分类号： C12N15/30 , C12N9/90 , C07K14/44 , G01N33/50 , G01N33/569 , G01N33/573 , C07K16/40 , C07K16/20 , C12Q1/68
CPC分类号： C12N9/90 , A61K2039/523 , A61K2039/57 , C07K2319/00 , Y02A50/41
摘要： The invention relates to the field of combating leishmaniases. Said invention results from the isolation, from wild isolates of Leishmania major, of a protein-coding gene known as LmPDI which has two regions that are identical to the sequence (Cys-Gly-His-Cys) of the potential active site of the protein disulphide isomerases (PDI). The LmPDI protein is predominantly expressed in the most virulent isolates of the parasite. Said protein forms a novel therapeutic target for developing anti-leishmaniasis medicaments and a novel element that can be used in the composition of immunogenic, and possibly vaccinating, preparations which are intended to protect a human or animal host against Leishmania.
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