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1.发明公开ANTIGENE MYCOBACTERIEN RECOMBINANT DE TYPE HEMAGGLUTININE DE LIAISON A L'HEPARINE (HBHA) METHYLEE 有权甲基化的重组分枝杆菌抗原肝素结合血细胞凝集素（HBHA）符合
公开(公告)号：EP1446422A2
公开(公告)日：2004-08-18
申请号：EP02795382.7
申请日：2002-11-18
发明人： PETHE, Kévin , MENOZZI, Franco , LOCHT, Camille
IPC分类号： C07K14/35
摘要： The invention concerns a methylated immunogenic recombinant peptide sequence comprising mycobacterial heparin-binding hemagglutinin. The invention also concerns chemical and enzymatic methods for preparing such a sequence, said sequence being previously produced in a non-methylated recombinant form then methylated by post-translational modification. The invention further concerns recombinant tools, vectors and host cells for implementing post-translational enzymatic methylation of the recombinant HBHA. The invention finally concerns immunogenic compositions comprising methylated, native or recombinant HBHA, such compositions being useful for preparing vaccines against mycobacterial infections.
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2.发明授权ANTIGENE MYCOBACTERIEN RECOMBINANT DE TYPE HEMAGGLUTININE DE LIAISON A L'HEPARINE (HBHA) METHYLEE 有权甲基化的重组分枝杆菌抗原肝素结合血细胞凝集素（HBHA）符合
公开(公告)号：EP1446422B1
公开(公告)日：2011-08-31
申请号：EP02795382.7
申请日：2002-11-18
发明人： PETHE, Kévin , MENOZZI, Franco , LOCHT, Camille
IPC分类号： C07K14/35
摘要： The invention concerns a methylated immunogenic recombinant peptide sequence comprising mycobacterial heparin-binding hemagglutinin. The invention also concerns chemical and enzymatic methods for preparing such a sequence, said sequence being previously produced in a non-methylated recombinant form then methylated by post-translational modification. The invention further concerns recombinant tools, vectors and host cells for implementing post-translational enzymatic methylation of the recombinant HBHA. The invention finally concerns immunogenic compositions comprising methylated, native or recombinant HBHA, such compositions being useful for preparing vaccines against mycobacterial infections.
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