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1.发明公开
公开(公告)号：EP1292333A1
公开(公告)日：2003-03-19
申请号：EP01945376.0
申请日：2001-06-07
CPC分类号： C07K14/235 , A61K39/099 , A61K39/39 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/55511 , A61K2039/55516 , Y02A50/412 , Y02A50/423
摘要： The invention concerns the use of the FHA protein or part of the FHA protein, in free form, as adjuvant of the immune response or as immunostimulant in a human or an animal. The invention also concerns adjuvant and immunostimulatory compositions comprising FHA protein or a fragment thereof, and the use of said compositions for making vaccines.
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2.发明公开ANTIGENE MYCOBACTERIEN RECOMBINANT DE TYPE HEMAGGLUTININE DE LIAISON A L'HEPARINE (HBHA) METHYLEE 有权甲基化的重组分枝杆菌抗原肝素结合血细胞凝集素（HBHA）符合
公开(公告)号：EP1446422A2
公开(公告)日：2004-08-18
申请号：EP02795382.7
申请日：2002-11-18
发明人： PETHE, Kévin , MENOZZI, Franco , LOCHT, Camille
IPC分类号： C07K14/35
摘要： The invention concerns a methylated immunogenic recombinant peptide sequence comprising mycobacterial heparin-binding hemagglutinin. The invention also concerns chemical and enzymatic methods for preparing such a sequence, said sequence being previously produced in a non-methylated recombinant form then methylated by post-translational modification. The invention further concerns recombinant tools, vectors and host cells for implementing post-translational enzymatic methylation of the recombinant HBHA. The invention finally concerns immunogenic compositions comprising methylated, native or recombinant HBHA, such compositions being useful for preparing vaccines against mycobacterial infections.
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3.发明授权VACCINE FOR PROPHYLAXIS OR TREATMENT OF AN ALLERGEN-DRIVEN AIRWAY PATHOLOGY 有权疫苗的预防与治疗经过一个过敏原诱发呼吸道疾病
公开(公告)号：EP2424564B1
公开(公告)日：2015-02-25
申请号：EP10715245.6
申请日：2010-04-26
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , INSTITUT PASTEUR DE LILLE , National University of Ireland, Maynooth
IPC分类号： A61K39/10
CPC分类号： A61K39/099 , A61K2039/522 , A61K2039/523 , A61K2039/543 , A61K2039/544
摘要： The present invention relates to a life attenuated Bordetella pertussis vaccine which is deficient for tracheal cytotoxin (TCT), pertussis toxin (PTX), and dermonecrotic toxin (DNT) for prophylaxis or treatment of an allergen-driven airway pathology.
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4.发明授权
公开(公告)号：EP1292333B1
公开(公告)日：2007-02-07
申请号：EP01945376.0
申请日：2001-06-07
CPC分类号： C07K14/235 , A61K39/099 , A61K39/39 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/55511 , A61K2039/55516 , Y02A50/412 , Y02A50/423
摘要： The invention concerns the use of the FHA protein or part of the FHA protein, in free form, as adjuvant of the immune response or as immunostimulant in a human or an animal. The invention also concerns adjuvant and immunostimulatory compositions comprising FHA protein or a fragment thereof, and the use of said compositions for making vaccines.
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5.发明授权VECTEURS NAVETTES POUR L'INTRODUCTION D'ADN DANS DES MYCOBACTERIES ET UTILISATION DE CES BACTERIES COMME VACCINS 失效将DNA EINSCHAEUSE矢量，分枝杆菌或使用细菌作为疫苗
公开(公告)号：EP0760859B1
公开(公告)日：2003-11-19
申请号：EP95920967.7
申请日：1995-05-19
CPC分类号： C12N9/0004 , C12N9/88 , C12N15/52 , C12N15/74 , C12Y116/01001
摘要： Shuttle vectors for the introduction of DNA into mycobacteria comprising at least one functional replication origin in said mycobacteria, another functional replication origin in other bacteria, an enzymatic cleavage site providing for the insertion of DNA coding for a protein susceptible of being expressed in the mycobacteria, characterized in that the vectors also carry a gene which makes the mycobacteria resistant to a compound containing a heavy metal.
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6.发明公开VECTEURS NAVETTES POUR L'INTRODUCTION D'ADN DANS DES MYCOBACTERIES ET UTILISATION DE CES BACTERIES COMME VACCINS 失效将DNA EINSCHAEUSE矢量，分枝杆菌或使用细菌作为疫苗
公开(公告)号：EP0760859A1
公开(公告)日：1997-03-12
申请号：EP95920967.0
申请日：1995-05-19
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , INSTITUT PASTEUR , INSTITUT PASTEUR DE LILLE
CPC分类号： C12N9/0004 , C12N9/88 , C12N15/52 , C12N15/74 , C12Y116/01001
摘要： Shuttle vectors for the introduction of DNA into mycobacteria comprising at least one functional replication origin in said mycobacteria, another functional replication origin in other bacteria, an enzymatic cleavage site providing for the insertion of DNA coding for a protein susceptible of being expressed in the mycobacteria, characterized in that the vectors also carry a gene which makes the mycobacteria resistant to a compound containing a heavy metal.
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公开(公告)号：EP3590532A1
公开(公告)日：2020-01-08
申请号：EP19176782.1
申请日：2010-04-26
申请人： Institut National de la Santé et de la Recherche Médicale , Institut Pasteur de Lille (IPL) , National University of Ireland, Maynooth
摘要： The present invention relates to a life attenuated Bordetella pertussis vaccine which is deficient for tracheal cytotoxin (TCT), pertussis toxin (PTX), and dermonecrotic toxin (DNT) for prophylaxis or treatment of an allergen-driven airway pathology.
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公开(公告)号：EP3436034A1
公开(公告)日：2019-02-06
申请号：EP17715426.7
申请日：2017-03-29
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9.发明公开VACCINE FOR PROPHYLAXIS OR TREATMENT OF AN ALLERGEN-DRIVEN AIRWAY PATHOLOGY 有权疫苗的预防与治疗经过一个过敏原诱发呼吸道疾病
公开(公告)号：EP2424564A1
公开(公告)日：2012-03-07
申请号：EP10715245.6
申请日：2010-04-26
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , INSTITUT PASTEUR DE LILLE , National University of Ireland, Maynooth
IPC分类号： A61K39/10
CPC分类号： A61K39/099 , A61K2039/522 , A61K2039/523 , A61K2039/543 , A61K2039/544
摘要： The present invention relates to a life attenuated Bordetella pertussis vaccine which is deficient for tracheal cytotoxin (TCT), pertussis toxin (PTX), and dermonecrotic toxin (DNT) for prophylaxis or treatment of an allergen-driven airway pathology.
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10.发明公开
公开(公告)号：EP0918854A1
公开(公告)日：1999-06-02
申请号：EP97937621.0
申请日：1997-08-12
发明人： MAGDALENA, Juana , SUPPLY, Philip , LOCHT, Camille
CPC分类号： C12N15/11 , C07K14/35 , C12Q1/689 , Y10S435/81
摘要： The invention concerns a M. tuberculosis complex mycobacteria specific fragment of nucleic acids, comprising a nucleotide chain selected among the SEQ ID NO. 1 sequence, the SEQ ID No 2 sequence, their complementary sequences or the nucleic acid sequences capable of being hybridised with one of the preceding sequences in conditions of high stringency. The invention also concerns uses of said sequences for the detection and differential diagnosis of mycobacteria members of the M. tuberculosis complex, in particular the BCG differential diagnosis of other members of the complex.
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