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1.发明公开
公开(公告)号：EP1292333A1
公开(公告)日：2003-03-19
申请号：EP01945376.0
申请日：2001-06-07
CPC分类号： C07K14/235 , A61K39/099 , A61K39/39 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/55511 , A61K2039/55516 , Y02A50/412 , Y02A50/423
摘要： The invention concerns the use of the FHA protein or part of the FHA protein, in free form, as adjuvant of the immune response or as immunostimulant in a human or an animal. The invention also concerns adjuvant and immunostimulatory compositions comprising FHA protein or a fragment thereof, and the use of said compositions for making vaccines.
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2.发明公开ANTIGENE MYCOBACTERIEN RECOMBINANT DE TYPE HEMAGGLUTININE DE LIAISON A L'HEPARINE (HBHA) METHYLEE 有权甲基化的重组分枝杆菌抗原肝素结合血细胞凝集素（HBHA）符合
公开(公告)号：EP1446422A2
公开(公告)日：2004-08-18
申请号：EP02795382.7
申请日：2002-11-18
发明人： PETHE, Kévin , MENOZZI, Franco , LOCHT, Camille
IPC分类号： C07K14/35
摘要： The invention concerns a methylated immunogenic recombinant peptide sequence comprising mycobacterial heparin-binding hemagglutinin. The invention also concerns chemical and enzymatic methods for preparing such a sequence, said sequence being previously produced in a non-methylated recombinant form then methylated by post-translational modification. The invention further concerns recombinant tools, vectors and host cells for implementing post-translational enzymatic methylation of the recombinant HBHA. The invention finally concerns immunogenic compositions comprising methylated, native or recombinant HBHA, such compositions being useful for preparing vaccines against mycobacterial infections.
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3.发明授权
公开(公告)号：EP1292333B1
公开(公告)日：2007-02-07
申请号：EP01945376.0
申请日：2001-06-07
CPC分类号： C07K14/235 , A61K39/099 , A61K39/39 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/55511 , A61K2039/55516 , Y02A50/412 , Y02A50/423
摘要： The invention concerns the use of the FHA protein or part of the FHA protein, in free form, as adjuvant of the immune response or as immunostimulant in a human or an animal. The invention also concerns adjuvant and immunostimulatory compositions comprising FHA protein or a fragment thereof, and the use of said compositions for making vaccines.
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4.发明公开
公开(公告)号：EP0914437A2
公开(公告)日：1999-05-12
申请号：EP97925109.0
申请日：1997-05-20
发明人： MENOZZI, Franco , LOCHT, Camille
摘要： The invention features peptide sequences enabling mycobacteria adhesion to host cells, in particular to epithelial cells. More particularly, the invention features a mycobacterial antigen of the heparin-binding haemagglutinin type (HBHA) obtained from Mycobacterium bovis BCG or Mycobacterium tuberculosis. The invention also features a recombinant peptide sequence enabling mycobacteria adhesion to host cells. The invention particularly features the expression product of an Escherichia coli strain transformed with a nucleotide sequence coding for a protein enabling mycobacteria adhesion to host cells. These peptide sequences can be used in immunogenic compositions, for preparing vaccines against mycobacterial infections, and for mycobacterial infection serological diagnosis.
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5.发明公开PROTEINES RECOMBINANTES DE L'HEMAGGLUTININE FILAMENTEUSE DE $i(BORDETELLA), NOTAMMENT $i(BORDETELLA PERTUSSIS), PROCEDE POUR LEUR PRODUCTION ET LEURS APPLICATIONS A LA PRODUCTION DE PROTEINES ETRANGERES OU DE PRINCIPES ACTIFS VACCINANTS 失效百日咳，尤其是百日咳百日咳，方法与VERWENDUNGZUR重组PROTEUINE丝状HAEMAGLUTININS产生杂质蛋白或疫苗
公开(公告)号：EP0755447A1
公开(公告)日：1997-01-29
申请号：EP95918030.0
申请日：1995-04-19
申请人： INSTITUT PASTEUR , INSTITUT PASTEUR DE LILLE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
发明人： LOCHT, Camille , RENAULD, Geneviève , CAPRON, André , RIVEAU, Gilles , MENOZZI, Franco , JACOB-DUBUISSON, Françoise
CPC分类号： C07K14/235 , C07K2319/00
摘要： A recombinant DNA containing a sequence (1) coding for a polypeptide heterologous to a filamentous haemagglutinin of Bordetella (Fha) fused within the same reading frame to a sequence (2) located upstream from the first sequence. Said sequence (2) codes for at least a part of the Fha precursor, which part comprises at least the N-terminal region of a truncated mature Fha protein which contains the interaction site of Fha and heparin, and which, when it is itself subjected on its own to the control of a promoter recognised by the cell polymerases of B. Pertussis, and inserted into a B. Pertussis cell culture, is expressed in said culture under the control of said promoter and excreted into the cell culture medium. The invention uses both the abilities of Bordetella, and particularly B. Pertussis, which does not appear to produce extracellular proteases, and the ease with which filamentous haemagglutinins can be isolated from those of the Bordetella synthesising same.
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6.发明授权
公开(公告)号：EP0914437B1
公开(公告)日：2006-05-31
申请号：EP97925109.7
申请日：1997-05-20
发明人： MENOZZI, Franco , LOCHT, Camille
IPC分类号： C12N15/31 , G01N33/569 , C07K14/35 , C07K16/12 , A61K39/04
摘要： The invention features peptide sequences enabling mycobacteria adhesion to host cells, in particular to epithelial cells. More particularly, the invention features a mycobacterial antigen of the heparin-binding haemagglutinin type (HBHA) obtained from Mycobacterium bovis BCG or Mycobacterium tuberculosis. The invention also features a recombinant peptide sequence enabling mycobacteria adhesion to host cells. The invention particularly features the expression product of an Escherichia coli strain transformed with a nucleotide sequence coding for a protein enabling mycobacteria adhesion to host cells. These peptide sequences can be used in immunogenic compositions, for preparing vaccines against mycobacterial infections, and for mycobacterial infection serological diagnosis.
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7.发明授权ANTIGENE MYCOBACTERIEN RECOMBINANT DE TYPE HEMAGGLUTININE DE LIAISON A L'HEPARINE (HBHA) METHYLEE 有权甲基化的重组分枝杆菌抗原肝素结合血细胞凝集素（HBHA）符合
公开(公告)号：EP1446422B1
公开(公告)日：2011-08-31
申请号：EP02795382.7
申请日：2002-11-18
发明人： PETHE, Kévin , MENOZZI, Franco , LOCHT, Camille
IPC分类号： C07K14/35
摘要： The invention concerns a methylated immunogenic recombinant peptide sequence comprising mycobacterial heparin-binding hemagglutinin. The invention also concerns chemical and enzymatic methods for preparing such a sequence, said sequence being previously produced in a non-methylated recombinant form then methylated by post-translational modification. The invention further concerns recombinant tools, vectors and host cells for implementing post-translational enzymatic methylation of the recombinant HBHA. The invention finally concerns immunogenic compositions comprising methylated, native or recombinant HBHA, such compositions being useful for preparing vaccines against mycobacterial infections.
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8.发明授权
公开(公告)号：EP0755447B1
公开(公告)日：2003-07-02
申请号：EP95918030.8
申请日：1995-04-19
发明人： LOCHT, Camille , RENAULD, Geneviève , CAPRON, André , RIVEAU, Gilles , MENOZZI, Franco , JACOB-DUBUISSON, Françoise
IPC分类号： C12N15/31 , C12N15/62 , C07K14/235 , C12N1/21 , A61K39/10
CPC分类号： C07K14/235 , C07K2319/00
摘要： A recombinant DNA containing a sequence (1) coding for a polypeptide heterologous to a filamentous haemagglutinin of Bordetella (Fha) fused within the same reading frame to a sequence (2) located upstream from the first sequence. Said sequence (2) codes for at least a part of the Fha precursor, which part comprises at least the N-terminal region of a truncated mature Fha protein which contains the interaction site of Fha and heparin, and which, when it is itself subjected on its own to the control of a promoter recognised by the cell polymerases of B. Pertussis, and inserted into a B. Pertussis cell culture, is expressed in said culture under the control of said promoter and excreted into the cell culture medium. The invention uses both the abilities of Bordetella, and particularly B. Pertussis, which does not appear to produce extracellular proteases, and the ease with which filamentous haemagglutinins can be isolated from those of the Bordetella synthesising same.
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