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    COMPOSITIONS AND METHODS FOR TREATING CORONAVIRUS INFECTION AND SARS
    1.
    发明公开
    COMPOSITIONS AND METHODS FOR TREATING CORONAVIRUS INFECTION AND SARS 审中-公开
    用于控制冠状病毒和SARS感染的组合物和方法

    公开(公告)号：EP1651271A4

    公开(公告)日：2006-11-08

    申请号：EP04749378

    申请日：2004-03-12

    申请人： INTERMUNE INC

    发明人： BLATT LAWRENCE M

    IPC分类号： A61K38/21 ,  A61K20060101 ,  A61K31/7056 ,  A61K39/215 ,  A61K39/225 ,  A61K45/00 ,  A61K47/00 ,  A61K47/30 ,  A61P11/00 ,  A61P31/12 ,  A61P31/14

    CPC分类号： A61K31/7056 ,  A61K38/212 ,  A61K38/217 ,  A61K2300/00

    摘要： The present invention provides methods of treating a coronavirus infection, and methods of reducing viral load, or reducing the time to viral clearance, or reducing morbidity or mortality in the clinical outcomes, in patients suffering from a coronavirus infection. The present invention further provides methods of reducing the risk that an individual will develop a pathological coronavirus infection, that has clinical sequelae. The present invention further provides methods of reducing the risk that an individual will develop SARS. The present invention further provides methods of treating SARS. The methods generally involve administering a therapeutically effective amount of a Type I or Type III interferon receptor agonist and/or a Type II interferon receptor agonist for the treatment of a coronavirus infection.

    SYNTHETIC CHEMOKINE RECEPTOR LIGANDS AND METHODS OF USE THEREOF
    2.
    发明公开
    SYNTHETIC CHEMOKINE RECEPTOR LIGANDS AND METHODS OF USE THEREOF 审中-公开
    合成趋化因子受体配体和应用过程THEREOF

    公开(公告)号：EP1633317A4

    公开(公告)日：2008-08-20

    申请号：EP04776018

    申请日：2004-05-13

    申请人： INTERMUNE INC

    发明人： BLATT LAWRENCE M

    IPC分类号： C07K14/52 ,  A61K20060101 ,  A61K38/00 ,  A61K38/19

    CPC分类号： C07K14/521 ,  A61K38/00 ,  C07K14/522

    摘要： The present invention provides synthetic CXCR3 ligands, including consensus CXCR3 ligands and hybrid CXCR3 ligands; and compositions comprising the ligands. The present invention provides polynucleotides encoding the synthetic CXCR3 ligands; expression vectors comprising the polynucleotides; and host cells comprising the polynucleotidess. The present invention provides methods of treating fibrotic disorders; methods of treating angiogenic disorders; methods of treating cancer; and methods of treating bacterial infections. The methods generally involve administering to an individual in need thereof an effective amount of a subject synthetic CXCR3 ligand.