公开(公告)号：EP3167396A4

公开(公告)日：2018-03-21

申请号：EP15818218

申请日：2015-07-10

申请人： IOGENETICS LLC

发明人： BREMEL ROBERT D ,  HOMAN JANE ,  IMBODEN MICHAEL

IPC分类号： G06F19/18 ,  G06F19/24 ,  G06N3/08

CPC分类号： G06F19/22 ,  G01N33/6854 ,  G01N33/6878 ,  G01N2800/24 ,  G06F19/18 ,  G06F19/28

摘要： The present invention provides methods and systems for identifying and classifying epitopes and use of that information to analyze proteins and peptides within proteins, especially potential epitopes, and to use the information to design synthetic peptides and proteins, analyze biopharmaceutical proteins, and diagnose autoimmune conditions. Peptides which are bound in MHC grooves comprise two sets of amino acids: those that face inwards into the groove and determine the binding affinity to the MHC molecule (the groove exposed motifs or GEM) and those which do not interact with the groove but rather are on the obverse side exposed outwardly to the T-cells (the T-cell exposed Motifs or TCEM). The present invention utilizes information related to the identity and physiochemical characteristics of the GEM and TCEM.

公开(公告)号：EP1933874A4

公开(公告)日：2010-03-03

申请号：EP06825629

申请日：2006-10-10

申请人： IOGENETICS LLC ,  UNIV ARIZONA STATE

发明人： IMBODEN MICHAEL ,  RIGGS MICHAEL W ,  SCHAEFER DEBORAH

IPC分类号： A61K39/40 ,  A61K47/48 ,  C07K16/12 ,  C07K16/20

CPC分类号： C07K16/14 ,  A61K2039/505 ,  C07K16/20 ,  C07K2317/12 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2319/30 ,  C07K2319/55

公开(公告)号：EP2381788A4

公开(公告)日：2013-01-02

申请号：EP10732041

申请日：2010-01-13

申请人： IOGENETICS LLC ,  UNIV ARIZONA STATE

发明人： IMBODEN MICHAEL ,  RIGGS MICHAEL ,  SCHAEFER DEBORAH A ,  HOMAN JANE

IPC分类号： A01N63/02 ,  A01N63/00 ,  A01P1/00 ,  A01P3/00 ,  A61K38/16 ,  A61K39/44 ,  C07K16/00 ,  C07K19/00 ,  C12N15/62 ,  C12N15/867

CPC分类号： C07K16/20 ,  A01K2217/052 ,  A01K2217/206 ,  A01K2227/101 ,  A01K2267/01 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/01 ,  C07K2319/035 ,  C12N2740/13043

摘要： The present invention relates to fusion proteins comprising a microorganism targeting molecule (e.g., immunoglobulin) and a biocide. The present invention also relates to therapeutic and prophylactic methods of using a fusion protein comprising a microorganism targeting molecule and a biocide in diverse fields.