公开(公告)号：EP3167396A4

公开(公告)日：2018-03-21

申请号：EP15818218

申请日：2015-07-10

申请人： IOGENETICS LLC

发明人： BREMEL ROBERT D ,  HOMAN JANE ,  IMBODEN MICHAEL

IPC分类号： G06F19/18 ,  G06F19/24 ,  G06N3/08

CPC分类号： G06F19/22 ,  G01N33/6854 ,  G01N33/6878 ,  G01N2800/24 ,  G06F19/18 ,  G06F19/28

摘要： The present invention provides methods and systems for identifying and classifying epitopes and use of that information to analyze proteins and peptides within proteins, especially potential epitopes, and to use the information to design synthetic peptides and proteins, analyze biopharmaceutical proteins, and diagnose autoimmune conditions. Peptides which are bound in MHC grooves comprise two sets of amino acids: those that face inwards into the groove and determine the binding affinity to the MHC molecule (the groove exposed motifs or GEM) and those which do not interact with the groove but rather are on the obverse side exposed outwardly to the T-cells (the T-cell exposed Motifs or TCEM). The present invention utilizes information related to the identity and physiochemical characteristics of the GEM and TCEM.

公开(公告)号：EP3008204A4

公开(公告)日：2017-01-04

申请号：EP14810932

申请日：2014-06-09

申请人： IOGENETICS LLC

发明人： BREMEL ROBERT D

IPC分类号： C12Q1/37 ,  C40B50/02 ,  G01N33/48 ,  G06F19/18

CPC分类号： G06F19/18 ,  G06N3/0472 ,  G06N3/08

公开(公告)号：EP2771349A4

公开(公告)日：2015-06-17

申请号：EP12831761

申请日：2012-09-13

申请人： IOGENETICS LLC

发明人： BREMEL ROBERT D ,  HOMAN JANE

IPC分类号： C07K1/00 ,  A61K39/00 ,  A61K39/04 ,  A61K39/08 ,  A61K39/085 ,  A61K39/09 ,  A61K39/145 ,  A61K39/15 ,  A61K39/21 ,  A61K39/285 ,  C07K5/00 ,  C07K14/00 ,  G01N33/53 ,  G06F19/16

CPC分类号： A61K39/00 ,  A61K39/0007 ,  A61K39/0008 ,  A61K39/04 ,  A61K39/08 ,  A61K39/085 ,  A61K39/092 ,  A61K39/12 ,  A61K39/145 ,  A61K39/15 ,  A61K39/21 ,  A61K39/285 ,  A61K2039/55572 ,  C12N2710/24034 ,  C12N2720/12334 ,  C12N2740/14034 ,  C12N2760/16134 ,  G06F19/16

摘要： This invention relates to the identification of peptide binding to ligands, and in particular to identification of epitopes expressed by microorganisms and by mammalian cells. The present invention provides polypeptides comprising the epitopes, and vaccines, antibodies and diagnostic products that utilize or are developed using the epitopes.

公开(公告)号：EP2550529A4

公开(公告)日：2016-11-02

申请号：EP11759984

申请日：2011-03-21

申请人： IOGENETICS LLC

发明人： BREMEL ROBERT D ,  HOMAN JANE

IPC分类号： G06F19/18 ,  C40B50/02 ,  G01N33/48

CPC分类号： G06F19/18 ,  G06F19/24

公开(公告)号：EP3166631A4

公开(公告)日：2018-03-21

申请号：EP15819480

申请日：2015-07-10

申请人： IOGENETICS LLC

发明人： BREMEL ROBERT D ,  HOMAN JANE

IPC分类号： A61K39/00 ,  A61K38/00 ,  A61K38/08 ,  A61K39/38 ,  C07K16/00 ,  C40B30/04 ,  C40B30/10 ,  C40B50/02

CPC分类号： C07K16/00 ,  C07K2317/12 ,  C07K2317/20 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/94

摘要： The present invention provides a means to prepare a product from domestic animal milk, blood or eggs which comprises an array of T-cell exposed motifs similar in identity, distribution and concentration to those found in human immunoglobulin variable regions and to prepare and apply the product as an immune modulating agent for administration either as a nutritional supplement or as a pharmaceutical product.